Clinical trials: sponsored by University Medical Center Groningen
Appendicitis Acute, Acute Abdomen in Children
The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care
BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g.
- Trial name
- ISAAK (NCT06762275)
- Testing
- Diagnostic strategy
- Where
- Netherlands
- Volunteers
- 566 people
- Sponsor
- University Medical Center Groningen
Chronic Respiratory Failure, Non-invasive Ventilation
Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach
The aim of the data collection is to create an advanced reliable method to remotely monitor patient on chronic home non-invasive ventilation (NIV), both regarding ventilatory efficacy and patient comfort, both in the hospital and…
- Trial name
- NOCTIVENT (NCT05756387)
- Testing
- Non-invasive ventilation
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Cervical Cancer
Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer
This is a nationwide, multicenter, registry-based prospective cohort study to assess real-world effectiveness of treatment with a pembrolizumab containing regimen in persistent, recurrent, or metastatic cervical cancer.
- Trial name
- PROTECx (NCT07645625)
- Testing
- Early discontinuation of Pembrolizumab with or without Bevacizumab
- Where
- 11 sites in Netherlands
- Volunteers
- 261 people
- Sponsor
- University Medical Center Groningen
Neonatal Hyperbilirubinemia, Treatment Decisions
Bilirubin Thresholds in Preterm Infants on Neonatal Intensive CarE Units: The B-NICE Trial
Rationale: Neonatal hyperbilirubinemia is highly prevalent in very preterm infants born <30 weeks. Since 2008, uniform Dutch phototherapy thresholds for preterm infants have been used nationwide, largely based on consensus.
- Conditions
- Neonatal Hyperbilirubinemia, Treatment Decisions, Neurodevelopmental Outcome, Phototherapy
- Trial name
- B-NICE (NCT07674537)
- Testing
- Phototherapy, Exchange Transfusion
- Where
- Netherlands
- Volunteers
- 680 people
- Sponsor
- University Medical Center Groningen
Mild Traumatic Brain Injury
Multicenter Early Intervention Study in Adults With Complaints After Mild Traumatic Brain Injury
Rationale: In the Netherlands, traumatic brain injury (TBI) is one of the most frequent neurological diseases and one of the leading causes of disability.
- Trial name
- BRAIN-RESET (NCT07341074)
- Testing
- Treatment by physical- and/or occupational therapist, Psychoeducation via telephonic counselling
- Where
- Netherlands
- Volunteers
- 655 people
- Sponsor
- University Medical Center Groningen
Cervical Carcinoma
Neoadjuvant Lymph Node Targeted Immunotherapy in Cervical Cancer: a Feasibility Study (NEOLYNC)
We aim to determine feasibility, safety and efficacy of TDLN-targeted immune checkpoint inhibition in different doses (nivolumab) in patients with cervical cancer.
- Trial name
- NEOLYNC (NCT07653503)
- Testing
- Nivolumab
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Depression in Remission
Mechanisms of Change of Positive Interventions in Reducing Vulnerability for Depression
The purpose of this study is to understand the effects of mindfulness and fantasizing in reducing perseverative cognition underlying vulnerability for depression.
- Trial name
- MINDCOG (NCT06145984)
- Testing
- Mindfulness, Positive Fantasizing
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Hepatic Artery Thrombosis, Hepatic Artery Stenosis
Hepatic Artery Stenosis and Thrombosis After Liver Transplantation in Children
The goal of this observational study is to investigate the incidence, current management practices, and outcomes in pediatric patients with HAC after liver transplantation.
- Conditions
- Hepatic Artery Thrombosis, Hepatic Artery Stenosis, Pediatric ALL, Liver Transplant; Complications
- Trial name
- HEPATIC (NCT05818644)
- Where
- Netherlands
- Volunteers
- 583 people
- Sponsor
- University Medical Center Groningen
Barrett's Esophagus With or Without Dysplasia, Barrett Esophagus Adenocarcinoma
Development of Fluorescent Lectin Tracers With Dedicated Technology for in Vivo Detection of Esophageal Dysplasia in Barrett Patients
The goal of this clinical trial is to evaluate the feasibility of WGA-800CW with dedicated imaging systems for detection of invisible esophageal dysplasia in patients with Barrett's esophagus.
- Trial name
- GRAIN (NCT07643727)
- Testing
- WGA-800CW
- Where
- Netherlands
- Volunteers
- 49 people
- Sponsor
- University Medical Center Groningen
Non Small Cell Lung Cancer Metastatic
Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer
Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease will undergo an MRI of the brain to screen for brain disease.
- Trial name
- VULCAN (NCT05864794)
- Testing
- MRI
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Dental Implants, Single-tooth, Crown
Immediate Loading of Implants in the Aesthetic Zone Using Three-dimensionally Printed Provisional Crowns: a 1-year Prospective Case Series Study
Background There is a growing tendency to place a provisional crown immediately following implant placement. Clinical advantages are shortening of treatment duration and soft tissue guiding during healing resulting in better…
- Trial name
- NCT07629752
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Breast Cancer
Late Scan Time-point Optimalisation of 18F-Fluoroestradiol for the Large Field-of-view (LAFOV) PET/CT Scanner.
Currently, in routine patient care PET/CT scan protocols used on high sensitivity large field of-view (LAFOV) PET/CT systems are based on protocols that historically were developed for standard field-of-view (SAFOV) PET/CT…
- Trial name
- NCT07627269
- Testing
- Late scan time-point(s) optimalisation of 89Zr trastuzumab18F-Fluoroestradiol
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation
Hybrid Atrial Fibrillation Ablation Registry
Recently a combined approach of surgeon ablation in combination with endocardial ablation (hybrid ablation) has been introduced.
- Trial name
- NCT02516033
- Volunteers
- 250 people
- Sponsor
- University Medical Center Groningen
Depression
Improving Personal Recovery After Depression With a Blended Module (STAIRS)
Almost all mental healthcare treatments of depression focus on symptomatic recovery. However, such recovery does not inherently mean that personal recovery is reached.
- Trial name
- STAIRS (NCT05440812)
- Testing
- Storytelling and Training to Advance Individual Recovery Skills (STAIRS)
- Where
- 2 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
CKD, Cardiovascular Diseases
Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)
In this study, investigators will compare the effect of vicadrostat combined with empagliflozin with the effect of spironolactone combined with empagliflozin on renal function and changes in protein profiles in blood and urine.
- Conditions
- CKD, Cardiovascular Diseases, Heart Failure
- Trial name
- COMPARE-VS (NCT07304817)
- Testing
- vicadrostat / empagliflozin combination 1, Spironolactone (drug)
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Acute Disease
Simple Observational Critical Care Studies
Each year approximately 3000 patients are admitted to the intensive care unit (ICU) in the University Medical Center Groningen (UMCG). In-hospital mortality of patients with emergency admission approaches 25%.
- Conditions
- Critical Illness, Acute Disease, Shock
- Trial name
- SOCCS (NCT03553069)
- Where
- Netherlands
- Volunteers
- 800 people
- Sponsor
- University Medical Center Groningen
Quality of Life, COVID-19
COVID-19 Follow up Intensive Care Studies
Since the SARS-CoV-2 infection is relatively new, the long term attributable burden related to COVID19 has not been investigated yet.
- Trial name
- COFICS (NCT04460170)
- Where
- Netherlands
- Volunteers
- 122 people
- Sponsor
- University Medical Center Groningen
Patients Using Olanzapine, Quetiapine, Risperidone or Clozapine
No Guts No Glory Probiotics
The goal of this clinical trial is to learn if probiotics work to prevent or reduce metabolic side effects caused by antipsychotic medication in adults.
- Trial name
- NGNGP (NCT07606014)
- Testing
- Probiotic Formula
- Where
- 3 sites in Netherlands
- Volunteers
- 112 people
- Sponsor
- University Medical Center Groningen
Critically Ill, Organ Failure, Multiple
Heterogeneity of Critical Illness: a Cohort Study
Rationale: There is large heterogeneity in disease states of critically ill patients at ICU admittance and there is also large heterogeneity in their disease severity during ICU stay.
- Trial name
- HEALICS (NCT04502511)
- Testing
- Standard diagnosis test
- Where
- Netherlands
- Volunteers
- 5,000 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation (AF), Heart Failure
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
The goal of this clinical trial is to learn if conduction system pacing works as well as cardiac resynchronization therapy (CRT) post atrioventricular (AV) node ablation in adult patients with symptomatic heart failure and atrial…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Cardiac Pacing
- Trial name
- APAF-CSP (NCT07604727)
- Testing
- Conduction System Pacing, Cardiac resynchronization therapy
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 292 people
- Sponsor
- University Medical Center Groningen