Clinical trials: sponsored by University Medical Center Groningen
Atrial Fibrillation (AF)
The Added Value of Three-dimensional Electroanatomic Mapping For Accurate Delivery Of Pulsed Field Ablation In The Pulmonary Veins Compared To Pulsed Field Ablation With Fluoroscopy And/Or Intracardiac Echocardiography Alone In The Treatment Of Atrial Fibrillation: MAP-PFA Study
This is a randomized control trial that aims to evaluate the added value of electro-anatomical mapping to improve the quality of pulse field ablation lesions during Atrial fibrillation ablation.
- Trial name
- MAP-PFA (NCT07014423)
- Testing
- The Pulsed Field Ablation to Isolate the Pulmonary Vein with the utilization of FARAVIEW mapping software., The Pulsed Field Ablation to Isolate the Pulmonary Vein without the utilization of FARAVIEW mapping software.
- Where
- 2 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- University Medical Center Groningen
Healthy Participants
Virtual Reality Assisted Schema Therapy
Schema therapy helps people understand which emotional needs were not met during childhood, and how they can take care of those needs now.
- Trial name
- VRAST (NCT07171736)
- Testing
- Virtual Reality chairwork exercise, Imagination exercise
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Infertility, Male, Infertility
Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors
The cause of infertility can be due to a female factor or a male factor. In case of a male factor, it is often due to poor semen quality. However, the cause of poor quality is often unknown.
- Trial name
- SIRIUS (NCT05514223)
- Testing
- Biomaterial collection for observational purpose
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis)
Psilocybin Therapy for Psychological Distress in Palliative Patients
The goal of this clinical trial is to evaluate whether psilocybin therapy can effectively treat depression and psychological distress in adult patients with COPD, ALS, MS, or APD who have at least 6 months life expectancy.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), Major Depressive Disorder (MDD)
- Trial name
- PsyPal (NCT06782724)
- Testing
- Psilocybin therapy
- Where
- 4 sites in Czechia, Denmark and 2 more
- Volunteers
- 108 people
- Sponsor
- University Medical Center Groningen
Dialysis, Chronic Kidney Disease (Stages 4 and 5)
CANagliflozin In DIALysis Patients
Rationale: Sodium glucose co-transporter 2 (SGLT2) inhibitors are a relatively new class of drugs originally developed for the treatment of diabetes.
- Trial name
- CANIDIAP (NCT07527390)
- Testing
- Invokana 300 mg and 100 mg tablet
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Diabetes (DM), Critical Illness
Identifying Diabetes and Impaired Glucose Tolerance in ICU Patients
In the Netherlands, patients admitted to the ICU are classified as having diabetes based on whether their medical records indicate glucose management medication use (Dutch National Intensive Care Evaluation (NICE) Registry).
- Trial name
- DISCOVER (NCT07261865)
- Where
- 2 sites in Netherlands
- Volunteers
- 4,198 people
- Sponsor
- University Medical Center Groningen
Radiotherapy Side Effect, NSCLC
CPAP or BiPAP for Motion Mitigation During Radiotherapy
When using highly conformal radiotherapy techniques, such as proton therapy, a controlled breathing pattern and a minimal breathing amplitude could greatly benefit the treatment of mobile tumors.
- Conditions
- Radiotherapy Side Effect, NSCLC, Esophageal Cancer, Malignant Lymphoma
- Trial name
- SISTER (NCT04986293)
- Testing
- CPAP
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- University Medical Center Groningen
Ovarian Cancer
Phase 1 Study to Evaluate the Safety, Feasibility and Immunogenicity of an Allogeneic, Cell-based Vaccine (DCP-001) in High Grade Serous Ovarian Cancer Patients After Primary Treatment
Phase I study to evaluate safety and systemic immunogenicity of the DCP-001 vaccine in patients with high grade serous ovarian cancer after primary treatment.
- Trial name
- ALISON (NCT04739527)
- Testing
- DCP-001
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- University Medical Center Groningen
Rectal Cancer
Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial
Currently the 3-year disease free survival of patients with locally advanced rectal cancer is about 50%. Current standard treatment for patients at high risk of failing locally and/or systemically includes pre-operative long…
- Trial name
- RAPIDO (NCT01558921)
- Testing
- M1 scheme, standard long course chemoradiotherapy
- Where
- 56 sites in United States, Denmark and 5 more
- Volunteers
- 920 people
- Sponsor
- University Medical Center Groningen
Endometrial Cancer
Neo-adjuvant Pembrolizumab as an Alternative Treatment for MMRd Uterine Cancer
The goal of this clinical trial is to establish the fraction of patients that achieve a major pathological response (MPR) after 9 cycles of pembrolizumab, with the ultimate aim of informing a follow-up randomized trial.
- Trial name
- PAM-II (NCT06180733)
- Testing
- Pembrolizumab Injection [Keytruda]
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Emphysema
Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment
Rationale: Chronic obstructive pulmonary disease (COPD) is characterised by a high prevalence of peripheral muscle dysfunction, which can have significant clinical consequences, including decreased exercise capacity, reduced…
- Trial name
- ENDURANCE (NCT06025500)
- Testing
- 31P-Magnetic Resonance Spectroscopy (31P-MRS)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Obesity
PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery
Bariatric surgery (BS) is currently the most effective treatment in severe obesity. However, a considerable percentage of patients undergoing BS fail to lose sufficient weight or regain weight after initial weight loss during…
- Trial name
- ObesiPET (NCT05359887)
- Testing
- standardized liquid mixed meal Nutridrink®
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Lung Cancer
Standard Follow-up Program (SFP) for Lung Cancer Patients Treated With Radiotherapy or Chemoradiation
Motive: In order to improve the treatment technique, a comprehensive follow-up program is needed to obtain all relevant patient, treatment and toxicity data from lung cancer patients.
- Trial name
- NCT02421718
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
COPD
Change in Task-related Oxygen Uptake After EBV Treatment
Rationale: Bronchoscopic lung volume reduction using endobronchial valves (EBV) has emerged as a viable treatment option for eligible patients with severe emphysema.
- Trial name
- CROCODILE (NCT06702072)
- Testing
- Endobronchial valve treatment
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Heart Failure
Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands
Digoxin is the oldest, market-authorized drug for heart failure (HF), and very cheap. A large trial with digoxin, the DIG trial, executed in the early nineties revealed a highly significant reduction in HF hospitalizations, but…
- Trial name
- DECISION (NCT03783429)
- Testing
- Digoxin
- Where
- 44 sites in Netherlands
- Volunteers
- 982 people
- Sponsor
- University Medical Center Groningen
COPD
PEP-buddy in COPD: Effect on Dyspnea Severity and Mechanism of Action
Chronic dyspnea is the most characteristic symptom of patients with Chronic Obstructive Pulmonary Disease (COPD), with intermittent increases during exercise and other events.Despite optimal standard therapy, episodic dyspnea is…
- Trial name
- RELIEF (NCT05938738)
- Testing
- PEP-buddy
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis
Fatigue in MS: From Invisible to Measurable
Fatigue is one of the most common and burdensome symptoms of MS, but its precise cause remains unknown, and an effective treatment is lacking.
- Trial name
- FIMS (NCT07182903)
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Disease
FINE-START: Efficacy and Safety of Finerenone in Patients With Chronic Kidney Disease Not Using Renin-angiotensin-system Inhibitors
Study to demonstrate efficacy of finerenone when compared to placebo in reducing albuminuria in participants with chronic kidney disease (CKD) not using renin-angiotensin-system (RAS) inhibitors.
- Trial name
- FINE-START (NCT07181135)
- Testing
- Finerenone (BAY 94-8862)
- Where
- 8 sites in Spain
- Volunteers
- 180 people
- Sponsor
- University Medical Center Groningen
Barrett's Esophagus Without Dysplasia, Barrett Oesophagitis With Dysplasia
Oral Bevacizumab-800CW and Cetuximab-800CW Administration to Detect Early Esophageal Adenocarcinomas
Previous studies have confirmed the great potential of quantitative fluorescence molecular endoscopy (qFME) when looking at additional lesion detection initially missed by high-definition white light endoscopy (HD-WLE) for…
- Conditions
- Barrett's Esophagus Without Dysplasia, Barrett Oesophagitis With Dysplasia, Esophageal Adenocarcinoma
- Trial name
- SLURP (NCT05745857)
- Testing
- Avastin, Erbitux, Fluorescence endoscopy and multi-diameter single fiber reflectance/single fiber fluorescence (MDSFR/SFF) spectroscopy
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- University Medical Center Groningen