Clinical trials: sponsored by University of Bern
Smoking Cessation, Cardiovascular Diseases
The ESTxENDS Trial- Substudy on the Metabolic Effects of Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Metabolic outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612336)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Loneliness
Evaluation of the Efficacy of Two Internet-based Self-help Interventions for Loneliness.
In this study, people who suffer from loneliness will be randomized to three study conditions. The first and second group get an account to an internet-based self-help intervention.
- Trial name
- SOLUS-D (NCT04655196)
- Testing
- SOLUS-D + weekly feedback by a coach, SOLUS-D + weekly automated messages
- Where
- Switzerland
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Bern
Behavior, Health, Behavior, Maternal
Women Lift Safely! An Intervention Study to Reduce the Risks of Heavy Lifting
The Women Lift Safely! Intervention study aims to increase safe carrying behavior to reduce health risks of heavy lifting in a rural area of Nepal (i.e. reducing weight and using safe lifting techniques).
- Conditions
- Behavior, Health, Behavior, Maternal, Work Related Stress
- Trial name
- NCT05154006
- Testing
- Information about benefits of the behavior, Instruction on how to perform a behavior, Self-efficacy
- Where
- 2 sites in Nepal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mental Disorder
Acute-REMOTION: REMOTION in Acute Psychiatric Care
This study aims to examine REMOTION, an internet-based intervention aimed at reducing symptom severity and improving emotion regulation in an acute psychiatric inpatient care setting.
- Trial name
- Acute-REMOTION (NCT04990674)
- Testing
- REMOTION, TAU
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Healthy, Blood Pressure
The Effectiveness of the Wim Hof Method
The Wim Hof Method is a multi-disciplinary approach to physical and mental well-being combining cold exposure, breathing exercises, and meditation.
- Conditions
- Healthy, Blood Pressure, Cold Exposure, Stress
- Trial name
- NCT05894031
- Testing
- Wim Hof Method
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Bern
Failure of Dental Prosthesis
Comparison of Two Implant Prosthetic Pathways
To assess and compare the esthetic outcome and clinical performance of anterior maxillary all ceramic implant single crowns based either on prefabricated zirconia abutment veneered with pressed ceramics or on a CAD/CAM…
- Trial name
- NCT02905838
- Testing
- Anatomic e.max Abutment, CAD/CAM CARES Abutment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bern
Real tDCS, Sham tDCS
Supporting Decisions With Transcranial Direct Current Stimulation in Healthy Young and Elderly Individuals
Decisions are part of the daily life. On the neuronal level, activity in the dorsolateral prefrontal cortex (dlPFC) is important during complex decisions (e.g., whether something is emotional for a person or not).
- Trial name
- NCT03959462
- Testing
- real anodal transcranial direct current stimulation
- Where
- Switzerland
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- University of Bern
Hand Hygiene
Behavior Change in Context to Contain the Spread of COVID-19
Project BECCCS (=Behavior Change in Context to Contain the Spread of COVID-19) aims to optimise and test a behaviour change intervention to promote correct hand hygiene at key times in the short and long term.
- Trial name
- NCT04830761
- Testing
- Motivation, Habit, Social
- Where
- Switzerland
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mental Disorder, HIV Infections
Effect of a Psychological Intervention on Antiretroviral Therapy and Mental Health Outcomes in HIV-positive Adults in Zimbabwe
The aim of the study is to examine the effect of a psychological intervention on antiretroviral therapy outcomes and symptoms of common mental health disorders among adults living with HIV and common mental disorders in rural…
- Trial name
- NCT03704805
- Testing
- Friendship bench intervention, Enhanced Standard of Care
- Where
- Zimbabwe
- Volunteers
- 480 people
- Sponsor
- University of Bern
Emotional Stress, Embitterment
Effects of Social Exclusion in The Context of Chronic Embitterment
This experimental, anonymous labor study aims to examine how experiences of social exclusion influence individuals in their fairness-behaviour, psychophysical reactions, and emotion regulation depending on their extent of…
- Trial name
- EMBEX (NCT04350515)
- Testing
- Cyberball: Other Exclusion, Cyberball: Player Exclusion, Mindfulness: Emotion Regulation Task
- Where
- Switzerland
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Bern
Hiv, Drug Resistancy
The DTG-SWITCH Study: Longitudinal Analysis of Virologic Failure and Drug Resistance at and After Switching to Dolutegravir-based First-line ART
This is a prospective observational cohort study of 2820 patients on first-line ART switching to a DTG-based first-line regimen, according to the standard of care.
- Conditions
- Hiv, Drug Resistancy, Virologic Failure
- Trial name
- DTG-SWITCH (NCT04612452)
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 2,820 people
- Sponsor
- University of Bern
Gingival Recession
Ubiquinone (Coenzyme Q10) Application After Gingival Recession Coverage
This randomised double blinded clinical trial has the aim to assess the effect of ubiquinone (Coenzyme Q10) on early wound healing following gingival recession coverage.
- Trial name
- NCT04487652
- Testing
- Gingival recession coverage, with CoQ10 spray application
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bern
Osteoporosis, Vertebral Fracture
Study About the Effect of Preventive Adjacent Level Cement Augmentation After Osteoporotic Vertebral Compression Fractures
Vertebroplasty itself is challenged regarding its clinical efficacy. While two randomized controlled trials (RCTs) with substantial methodological problems have led to an intense discussion another RCT with larger case numbers…
- Trial name
- NCT02489825
- Testing
- Augmentation vertebroplasty, Augmentation and prophylactic vertebroplasty
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Bern
Insomnia Chronic
Acceptance and Commitment Therapy as a New Treatment for Adults With Insomnia Disorder
Acceptance and Commitment Therapy plus sleep restriction (ACT) will be compared to Cognitive Behavioral Therapy for insomnia (CBT-I). CBT-I is the first line treatment for insomnia according to current guidelines.
- Trial name
- NCT04252638
- Testing
- Acceptance and Commitment Therapy plus Sleep Restriction, Cognitive Behavioral Therapy including Sleep Restriction
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Neck Pain, Musculoskeletal Diseases
Exercise Intervention for Employees of the University of Bern
As part of a Swiss National Science Foundation SNSF project (On-site multi-component intervention to improve productivity and reduce the economic and personal burden of neck pain in Swiss Office-Workers, NEXpro = Neck EXercises…
- Conditions
- Neck Pain, Musculoskeletal Diseases, Occupational Health, Efficiency
- Trial name
- WeMoveVirtual (NCT05676528)
- Testing
- Exercise intervention
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bern
Schizophrenia and Related Disorders, Schizophrenia
Overcoming Psychomotor Slowing in Psychosis (OCoPS-P)
Psychomotor slowing is a major problem in psychosis. Aberrant function of the cerebral motor system is linked to psychomotor slowing in patients, particularly resting state hyperactivity in premotor cortices.
- Conditions
- Schizophrenia and Related Disorders, Schizophrenia, Schizoaffective Disorder, Brief Psychotic Disorder
- Trial name
- OCoPS-P (NCT03921450)
- Testing
- 1 Hz rTMS, iTBS
- Where
- Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mental Disorders
REMOTION: a Trial to Investigate the Feasibility and Potential Effectiveness of a Blended, Transdiagnostic Intervention for Symptom Reduction and Improvement of Emotion Regulation in an Outpatient Psychotherapeutic Setting
Emotion regulation has been identified as an important transdiagnostic factor in the treatment of mental health disorders. This study aims to examine, for the first time, REMOTION, a novel blended therapy intervention aimed at…
- Trial name
- REMOTION (NCT04262726)
- Testing
- REMOTION, TAU
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Bern
Stroke Gait Rehabilitation
Gait Rehabilitation Post Stroke:the Long Term Effect of Two Walking Aids -Canes and TheraTogs
Background 9000 people a year in Switzerland suffer a first time stroke. Of these 20 to 30% remain unable to walk and up to 60% are left with moderate to severe walking disability.
- Trial name
- NCT01366729
- Testing
- TheraTogs, Cane walking
- Where
- 3 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- Technical University of Bern
Mild Cognitive Impairment, Acquired Brain Injury
Long-term Tablet-computer Based Casual Puzzle Video Game Intervention in Healthy Older and Cognitively Impaired Persons
This study aims at investigating the effects of tablet-based puzzle video games on cognitive function and emotional well-being. This study extends preliminary findings of studies looking at short-term benefits of playing puzzle…
- Conditions
- Mild Cognitive Impairment, Acquired Brain Injury, Cognitive Impairment, Healthy
- Trial name
- NCT03139799
- Testing
- Experimental - Puzzle Video Game Intervention, Control - Tablet Newspaper Reading Intervention
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Bern
Aphasia, Chronic Stroke
A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.
The aim of this study is to investigate the effects of high-frequency short duration tablet-based speech and language therapy (teleSLT) mixed with cognitive training (teleCT) in chronic stroke patients.
- Conditions
- Aphasia, Chronic Stroke, Post Stroke Seizure
- Trial name
- NCT03228264
- Testing
- teleSLT, teleCT
- Where
- 2 sites in Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Bern