Clinical trials: open to volunteers, sponsored by University of Bern
Partial Edentulism
Digital and Conventional Clasp-retained Partial Dentures (DIGICLASP)
This single-center prospective observational cohort study evaluates two fabrication workflows already in routine clinical use for clasp-retained removable partial dentures (RPDs): a digital workflow (Group 1) and a conventional…
- Trial name
- DIGICLASP (NCT07903662)
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Bern
Dental Implant Failed
Clinical Performance of Dual-cantilevered Single-implant Bridge
The study aims to evaluate the clinical performance (implant and prosthetic survival/ success rates) of a novel implant-supported fixed dental prosthesis design: the dual-cantilevered single implant bridge (T-Bridge) made out of…
- Trial name
- T-bridge (NCT06099717)
- Testing
- Dual-cantilevered implant bridge, 3-unit iFDP
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Contrast Enhanced Ultrasound, Ultrasonic Diagnosis
International Delphi Study to Develop Standardized Quality Criteria and a Rating Tool for Liver CEUS Image Quality Assessment
This study aims to establish international consensus-based quality criteria for contrast-enhanced ultrasound (CEUS) examinations of the liver and to develop a standardized tool for assessing CEUS image and examination quality.
- Conditions
- Contrast Enhanced Ultrasound, Ultrasonic Diagnosis, Liver
- Trial name
- ICON LiverCEUS (NCT07656181)
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bern
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Stibium Metallicum Praeparatum D6 Versus Placebo in the Reduction of Paclitaxel-induced Peripheral Neurotoxicity
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most limiting side effects of chemotherapy and often leads to adaptations in the protocol of the chemotherapy including dose reduction or even discontinuation of…
- Trial name
- STING-CIPN (NCT04715542)
- Testing
- Stibium metallicum praeparatum 6x
- Volunteers
- 86 people
- Sponsor
- University of Bern
Depressive Disorder, Major Depressive Disorder, Healthy Volunteer
Exploring the Role of the Prefrontal Cortex in Decision-Making
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
- Trial name
- NCT07080489
- Testing
- Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/F4, Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/ kathodal F4
- Where
- Switzerland
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- University of Bern
Tooth Loss / Rehabilitation, Tooth Extraction
Ovate Pontic Versus Essix Provisional After Tooth Extraction and Alveolar Ridge Preservation (Pontic-Essix)
This randomized controlled trial compares two provisional socket-sealing concepts following single non-molar tooth extraction and alveolar ridge preservation: a fixed, tooth-supported, 3D-printed ovate pontic provisional…
- Conditions
- Tooth Loss / Rehabilitation, Tooth Extraction, Alveolar Bone Loss, Alveolar Ridge Augmentation
- Trial name
- Pontic-Essix (NCT07748871)
- Testing
- Bio-Oss Collagen, Mucograft Seal, Fixed 3D-printed ovate pontic provisional restoration
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Bern
Dental Implants
Implant-related Outcomes in the Context of Maxillary Sinus Lifting
The population of interest will be recruited out of a cohort of patients who were initially treated at the Department of Oral Surgery and Stomatology between 1997 and 2001.
- Trial name
- NCT06647381
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periodontitis, Periodontal Inflammation
PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy
Periodontitis is characterized by a chronic, multifactorial inflammatory process driven by dysbiotic plaque biofilms. It is recognized as the most common chronic inflammatory non-communicable disease in humans.
- Conditions
- Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- PRFSTEP2 (NCT07013682)
- Testing
- PRF as adjunct to non-surgical mechanical debridement, Control, non-surgical mechanical debridement alone
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Childhood Cancer
Swiss Childhood Cancer Survivor Study
The SCCSS is designed to investigate which long-term effects childhood cancer and its treatment have on survivors, and includes those who were under 20 years when they were diagnosed.
- Trial name
- SCCSS (NCT03297034)
- Where
- Switzerland
- Volunteers
- 4,136 people, healthy volunteers welcome
- Sponsor
- University of Bern
Lower Molar Requiring Extraction
Effect of Placing the Implant Crown on the Implant on the Same Day as the Implant vs. 4 Weeks Later.
In this study, participants with one lower first molar that require removal and replacement using dental implants will be enrolled.
- Trial name
- NCT04319042
- Testing
- Immediate Loading, Early Loading
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Bern
Cardiac Dysfunction, Cardiovascular Diseases
Cardiac Dysfunction in Childhood Cancer Survivors
This multicenter, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking…
- Conditions
- Cardiac Dysfunction, Cardiovascular Diseases, Childhood Cancer
- Trial name
- Cardio-Onco (NCT03790943)
- Testing
- cardiac assessment
- Where
- 6 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Connective Tissue Graft, Volume Collagen Matrix Xenograft
Volumetric Dimensional Changes After Surgical Pontic Site Development Procedures With Connective Tissue Graft or Collagen Matrix
The aim of this research project is to compare two surgical procedures to improve soft tissue volume. Both procedures have already been validated, but despite their great clinical relevance, little data exists in the literature.
- Trial name
- NCT06335628
- Testing
- Geistlich Fibro-Gide®
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Bern
Inappropriate Prescribing, Reflux Disease
Deprescribing Inappropriate Proton Pump Inhibitors
The DROPIT Trial is an interventional, open-labelled, cluster-randomized controlled trial conducted in the Swiss primary care setting.
- Conditions
- Inappropriate Prescribing, Reflux Disease, Proton Pump Inhibitors
- Trial name
- DROPIT (NCT06129474)
- Testing
- Proton Pump Inhibitor deprescribing tool
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Bern
Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue
Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome
Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions.
- Trial name
- CLEAR (NCT07400848)
- Testing
- Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bern
Asthma, Wheezing
Swiss Paediatric Airway Cohort
The Swiss Paediatric Airway Cohort (SPAC) is a national, prospective clinical cohort of children and adolescents who visit physicians in Switzerland for recurrent wheeze, cough, and exercise- or sleep-related respiratory…
- Conditions
- Asthma, Wheezing, Cough, Exercise Induced Bronchospasm
- Trial name
- SPAC (NCT03505216)
- Where
- 12 sites in Austria, Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University of Bern
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Peri-Implantitis, Bone Resorption
Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)
Platelet-rich fibrin (PRF) is a second-generation platelet concentrate used for tissue and bone regeneration. PRF releases growth factors such as TGF-β, PDGF, VEGF, IGF, and FGF, which are known to promote wound healing and bone…
- Conditions
- Peri-Implantitis, Bone Resorption, Platelet-Rich Fibrin
- Trial name
- PRF (NCT06679283)
- Testing
- Open flap debridement with a chemo-electric device + PRF, Open flap debridement with a chemo-electric device alone (control)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periapical Periodontitis
Hyaluronic Acid in Endodontic Microsurgery
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first…
- Trial name
- NCT07501585
- Testing
- Hyaluronic Acid, Endodontic microsurgery
- Where
- Russia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Bern
Gingival Recession, Connective Tissue Defect
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics.
- Trial name
- FibroGide (NCT07437417)
- Testing
- Volume stable collagen matrix, Control
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern