Clinical trials: open to volunteers, sponsored by University of British Columbia
Isthmic Spondylolisthesis
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis
Currently there is no consensus on the best surgical treatment of patients with symptomatic isthmic spondylolisthesis (IS). Clinical equipoise exists amongst experienced clinicians on the various surgical techniques available.
- Trial name
- NCT05701046
- Testing
- Interbody fusion surgery
- Where
- Canada
- Volunteers
- 489 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spinal Cord Injuries, Cardiovascular Diseases
Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury
The aim of this study is to examine the mechanisms of transcutaneous spinal cord stimulation (tSCS) for improving cardiovascular and pulmonary function in individuals with chronic motor-complete spinal cord injury (SCI) by…
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Cardiopulmonary Diseases
- Trial name
- NCT06379711
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Slipped Capital Femoral Epiphyses, SCFE
SCFE Longitudinal International Prospective Registry
Slipped Capital Femoral Epiphysis (SCFE) is the most common disorder of the adolescent hip and diagnosis and treatment of SCFE remain areas of controversy and investigation.
- Trial name
- SLIP (NCT04117841)
- Testing
- Observational
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Hypertension
TEC4Home Blood Pressure Randomized Controlled Trial
The goal of this clinical trial is to evaluate the effect of home blood pressure telemonitoring (HBPT) and case management (CM), relative to usual care, for improving blood pressure (BP) control among patients with high blood…
- Trial name
- NCT06303206
- Testing
- Home Blood Pressure Telemonitoring (HBPT) + Case Management (CM)
- Volunteers
- 408 people
- Sponsor
- University of British Columbia
Liver Transplantation, Immunosuppression
Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations
This is a randomized open label study in de novo liver transplant recipients that aims to compare the risk of tacrolimus induced tremors with once daily extended-release formulation, Envarsus, versus the twice daily…
- Conditions
- Liver Transplantation, Immunosuppression, Neurotoxicity, Tremor
- Trial name
- LCP-TAC (NCT05089604)
- Testing
- Tacrolimus, Immediate Release, Oral, Tacrolimus Extended Release Oral Tablet
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- University of British Columbia
Juvenile Idiopathic Arthritis
Personalized Estimates of Response and Severity Outcomes in Newly-diagnosed JIA
The PERSON-JIA Trial is a cluster-randomized trial testing the use of Shared Decision Making (SDM) with families for treatment of children with arthritis.
- Trial name
- PERSON-JIA (NCT05310799)
- Testing
- Shared Decision Making (SDM)
- Where
- Canada
- Volunteers
- 842 people
- Sponsor
- University of British Columbia
One-carbon Metabolism in Healthy Individuals
Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation
Periconceptional supplementation with folic acid - the synthetic form of the B-vitamin folate - reduces the occurrence of adverse pregnancy outcomes such as spina bifida.
- Trial name
- NCT01687127
- Testing
- Folic acid, 5-methyltetrahydrofolate, calcium salt
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obsessive-compulsive Disorder
Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder (OCD) is a common neuropsychiatric illness beginning in childhood. Effective OCD treatments include cognitive-behaviour therapy (CBT) and medications but access to treatment is difficult and does not…
- Trial name
- NCT01635569
- Testing
- Group-based family cognitive-behavioural therapy, Waitlist
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Respiratory Disease, Cystic Fibrosis
Measures of Respiratory Health Registry
There are many techniques that can allow for the quantification of lung function in children; some are being used clinically and others are under development. Many of these tools are available at BC Children's Hospital.
- Trial name
- MRH (NCT05501587)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University of British Columbia
Cystic Fibrosis
Canadian Observational Study Evaluating the Long-term IMPACT of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators on People With CF
This observational study intends to investigate health trends and data in cystic fibrosis patients all across Canada that are receiving modulator treatment so researchers can determine if CFTR treatments are effective over a long…
- Trial name
- Can-IMPACT CF (NCT05200429)
- Testing
- Trikafta
- Where
- 2 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Respiratory Disease, Healthy
Imaging Measures of Respiratory Health Registry
This is a prospective, observational cohort registry that aims to collect data on pulmonary structure and function in healthy people and those with respiratory disease, using structural and functional pulmonary 1H-MRI and…
- Trial name
- iMRH (NCT05102825)
- Testing
- 1H and Xe-129 MRI
- Where
- 2 sites in Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia