Clinical trials: sponsored by University of Calgary
Induced; Birth
The REDUCED-I Pilot Trial: REDucing the Utilization of CEsarean Sections With Induction
This pilot project is a randomized controlled trial where induced patients receive an intervention of oxytocin discontinuation once in the active stage of labor (≥6 cm dilation).
- Trial name
- (REDUCED-I) (NCT05037617)
- Testing
- Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cardiomyopathies
International Study of Artificial Intelligence-based Diagnosis of Cardiomyopathy Using Cardiac MRI (AID-MRI)
The goal of this observational study is to test the accuracy of computer (machine learning-based) algorithms to diagnosis heart diseases and predict if and when heart complications will occur.
- Trial name
- AID-MRI (NCT05793840)
- Where
- 2 sites in Canada
- Volunteers
- 1,100 people
- Sponsor
- University of Calgary
Cardiovascular Diseases
Cardiovascular Imaging Registry of Canada
A multi-site, multi-modality prospective observational clinical outcomes study focussed on the development of phenotype-dirven risk prediction modelling in patients with known or suspected cardiovascular disease.
- Trial name
- CIROC (NCT04367220)
- Testing
- Diagnostic testing performed as per routine care
- Where
- 4 sites in Canada
- Volunteers
- 45,000 people
- Sponsor
- University of Calgary
Methamphetamine, Methamphetamine Abuse
Delivering Contingency Management in Outpatient Addiction Treatment
Methamphetamine misuse has become a growing concern in Alberta, creating a burden on the health care system. Further, individuals who use methamphetamine in Alberta exhibit significant difficulty remaining in treatment.
- Conditions
- Methamphetamine, Methamphetamine Abuse, Methamphetamine-dependence, Contingency Management
- Trial name
- PRISE (NCT04544124)
- Testing
- Contingency management
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- University of Calgary
Occipital Neuralgia, Headache
Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia
This study is a randomized controlled trial, assessing the effect of a single platelet rich plasma (PRP) injection in post traumatic (concussive) greater occipital neuralgia.
- Trial name
- NCT04051203
- Testing
- Autologous Platelet Rich Plasma Injection, Depo-Medrol and lidocaine, Normal Saline
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Surgical Procedure, Unspecified, Communications Personnel
The Surgical Safety Checklist Revisited
The goal of this study is to develop and iteratively improve a toolkit - the "High-Performance Checklist" (HPC) toolkit - that provides clinicians with evidence-informed strategies for improving their Modification…
- Conditions
- Surgical Procedure, Unspecified, Communications Personnel, Tool Use Behavior
- Trial name
- NCT05700890
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University of Calgary
Rotator Cuff Tears
Rotator Cuff Augmentation With Human Dermal Allograft Versus Bovine Collagen Xenograft Patch: A Randomized Controlled Trial
Randomized controlled trial comparing human dermal allograft with bovine collagen xenograft in rotator cuff repair.
- Trial name
- HDA v Regen (NCT06215417)
- Testing
- Rotator cuff repair
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Bleeding UGI (During or Post-ERCP)
Incidence and Predictors of Bleeding During and Following ERCP
The incidence of bleeding during ERCP and following ERCP has been estimated using retrospective sources, but granular predictors of bleeding remain unknown, including the use of direct-acting anticoagulants and discontinuation…
- Trial name
- NCT05929404
- Where
- Canada
- Volunteers
- 5,872 people
- Sponsor
- University of Calgary
ERCP
Conscious Sedation Versus Anesthesia for ERCP
Studies directly comparing EDCS with AAS during ERCP are scarce, varying widely in their designs and reaching conflicting conclusions regarding safety and effectiveness.
- Trial name
- NCT05220774
- Where
- Canada
- Volunteers
- 3,174 people
- Sponsor
- University of Calgary
Delirium
Neuronal Damage In Delirium Study
The purpose of this study is to evaluate associations between neuronal damage biomarkers (S100 calcium-binding protein beta [S-100β], neuron-specific enolase [NSE], ubiquitin carboxy-terminal hydrolase L1 [UCHL1], and…
- Trial name
- NDID (NCT03724201)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Knee Osteoarthritis
Geniculate Artery Embolization for the Treatment of Knee Osteoarthritis
Osteoarthritis (OA) is a highly prevalent degenerative joint disease that contributes to chronic pain and disability in approximately 10% of people over the age of 55.
- Trial name
- NCT05386797
- Testing
- Geniculate Artery Embolization
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Psoriatic Arthritis, Obesity
Small Changes Behavioural Weight Loss Treatment Approach for Psoriatic Arthritis Patients With Comorbid Obesity
Psoriatic Arthritis (PsA) is a type of auto-immune condition that affects roughly 90,000 Canadians. Patients with PsA often experience joint pain, skin problems, and issues with mobility that negatively impact their quality of…
- Trial name
- NCT05225623
- Testing
- BWLT, Waitlist Control for BWLT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Calgary
Cicatrix, Hypertrophic
Fractional CO2 Laser Treatment of Hypertrophic Scars
Executive Summary Hypertrophic scars are irregular, raised scars that can cause debilitating symptoms including pain, pruritus, and restricted movement in nearby joints.
- Trial name
- NCT04236167
- Testing
- Fractional CO2 laser treatment -
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hyperglycemia
PGMP for Alberta Surgical Patients
Patients with postoperative hyperglycemia have higher complication rates and worse outcomes than patients with in-target glucose, including longer length-of-stay, more admissions to intensive care, increased readmission rates…
- Trial name
- NCT05036655
- Testing
- Perioperative glycemic management pathway
- Where
- 2 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Growth Failure
Human Milk Fortification With Adjustable Versus Targeted Method
Research question: Do preterm infants born <1250 g achieve better weight gain with targeted fortification compared with the adjustable fortification of human milk? Hypothesis: Targeted fortification of human milk results in…
- Trial name
- FAT (NCT04809350)
- Testing
- Adjustable Human Milk Fortification, Targeted Human Milk Fortification
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Asthma
Phenotyping Disease Severity in Asthma
The purpose of this study is to characterize and compare the molecular gene expression profile in endobronchial biopsies and cells recovered in bronchial washings from study subjects who have asthma of varying disease severity…
- Trial name
- NCT05078021
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Graft-vs-host Disease
Preemptive Therapy of GVHD
Graft-vs-host disease (GVHD) causes substantial mortality, morbidity and poor quality of life after blood or marrow transplantation (BMT).
- Trial name
- NCT01994824
- Testing
- rabbit antithymocyte globulin
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Acute Kidney Injury
Strategy for Uptake of Processes for Recognizing and Responding to Acute Kidney Injury
Acute kidney injury (AKI) is common and costly complication of major surgery. AKI can lead to prolonged hospitalization and a higher likelihood of dialysis, chronic kidney disease and death.
- Trial name
- SUPPORT AKI (NCT03564314)
- Testing
- SUPPORT AKI Clinical Decision Support
- Where
- 4 sites in Canada
- Volunteers
- 2,135 people
- Sponsor
- University of Calgary
Depression, Treatment Resistant Depression
The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder
The primary goals of this proof of concept clinical trial are to determine the effectiveness, safety and tolerability of oral FMT in adults with Treatment Resistant Depression (TRD).
- Trial name
- NCT04805879
- Testing
- FMT oral Capsules
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
Acute Kidney Injury (Nontraumatic), Coronary Artery Disease
Contrast RISK (Reducing Injury Sustained by Kidneys)
Diagnostic and therapeutic cardiac catheterization procedures are important interventions to reduce the risk of death, avoid future cardiovascular events, and improve quality of life of people with heart disease.
- Trial name
- Contrast RISK (NCT03453996)
- Testing
- Intervention, Control
- Where
- 3 sites in Canada
- Volunteers
- 7,280 people
- Sponsor
- University of Calgary