Clinical trials: sponsored by University of Calgary
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Cesarean Section Complications
Use Versus Non-use of Bladder Catheterization in Elective Cesarean Delivery
The goal of this randomized controlled trial is to investigate the impact of routine bladder catheterization in uncomplicated cesarean sections on time to ambulation, time to discharge, urinary retention, development of urinary…
- Trial name
- NCT06242756
- Testing
- Bladder catheterization
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Clinical High Risk for Developing Psychosis
Stepped Care for Youth at Risk of Psychosis
The study will recruit 60 young people who meet established criteria for being at clinical high risk for psychosis. They will be offered a range of psychological interventions starting with the most benign treatments in different…
- Trial name
- NCT04829292
- Testing
- Supportive therapy and CBT
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Multiple Sclerosis
Cannabis (THC vs. CBD) in Multiple Sclerosis
The goal of this clinical trial is to examine the effect of Cannabis components, THC and CBD, on cognition and bladder symptoms in people with Multiple Sclerosis (MS).
- Trial name
- NCT06261489
- Testing
- THC, CBD
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Choking
Evaluation of Foreign Body Airway Obstruction Interventions Among Young Children: A Prospective Cohort Study
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07817693
- Where
- Canada
- Volunteers
- 381 people
- Sponsor
- University of Calgary
Choking
Evaluation of Foreign Body Airway Obstruction Interventions: A Prospective Cohort Study of Adults and Children
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07814690
- Where
- Canada
- Volunteers
- 640 people
- Sponsor
- University of Calgary
Critical Illness
Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness
Patients requiring life support therapies in intensive care units are at very high risk of hospital-acquired infections. An important source of these infections is the accumulation of pathogenic bacteria in the microbiome of…
- Trial name
- MicroMod (NCT07813507)
- Testing
- Synbiotic, Standard of Care (SOC)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Foreign Body Airway Obstruction
Prospective Evaluation of Foreign Body Airway Obstruction Interventions Among Adults and Children
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07365137
- Testing
- Abdominal thrust, Back blows, Chest compressions/thrusts
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Calgary
Persisting Symptoms After Concussion
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persisting symptoms…
- Trial name
- PatACT (NCT06615908)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Foreign Body Airway Obstruction
Prospective Evaluation of Foreign Body Airway Obstruction Interventions Among Infants
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07348848
- Testing
- Chest compressions/thrusts, Back blows, Abdominal Thrusts
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- University of Calgary
Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV)
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
The goal of this randomized controlled trial is to evaluate the efficacy of psilocybin administered with Acceptance and Commitment Therapy (ACT) as an intervention to reduce post-traumatic stress disorder (PTSD) symptom burden in…
- Trial name
- PsiPTSD (NCT06885996)
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Calgary
Advanced Cancer, Demoralization
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
This pilot clinical trial will study psilocybin-assisted therapy for adults with advanced cancer who are experiencing demoralization, existential distress, or related psychological concerns.
- Conditions
- Advanced Cancer, Demoralization, Existential Distress, Psychological Distress
- Trial name
- PAT-MIND (NCT07791901)
- Testing
- PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Unruptured Cerebral Aneurysm
Evaluating Oral Peri-operative Acetylsalicylic Acid in Subjects Undergoing Endovascular Coiling-only of Unruptured Brain Aneurysms
This trial is a is a prospective, randomized (1:1) placebo-controlled, clinical trial with blinded endpoint assessment of 440 participants with unruptured brain aneurysm planned for endovascular treatment using coiling-only…
- Trial name
- EVOLVE (NCT04192955)
- Testing
- Acetyl Salicylate
- Where
- 9 sites in Canada, France
- Volunteers
- 440 people
- Sponsor
- University of Calgary
Investigating the Importance of the Subjective Psychedelic Experience
Subjective Experience Following Psilocybin
The purpose of this study is to determine the importance of the acute subjective experience induced by psilocybin (the primary component of "magic mushrooms") in facilitating positive outcomes.
- Trial name
- SEP-1 (NCT06768944)
- Testing
- Psilocybin high-dose, Psilocybin low-dose, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Growth Hormone Deficiency, Traumatic Brain Injury
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury
The goal of this observational study is to characterize the impact of growth hormone deficiency (GHD) on quality of life, symptom burden, and sleep in adults with traumatic brain injury (TBI), and to evaluate whether these…
- Trial name
- NCT07795736
- Testing
- Not applicable (observational study)
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pelvic Organ Prolapse
How Low Can You Go
This is a randomized controlled trial to determine if lower intraabdominal operating pressure reduces post-operative pain in patients scheduled to undergo laparoscopic uterosacral suspension surgery of the uterus or vaginal vault.
- Trial name
- NCT07786337
- Testing
- Standard insufflation, Low insufflation
- Volunteers
- 164 people
- Sponsor
- University of Calgary
Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty
Continuous Interscalene Blocks and Rebound Pain
The primary objectives of this present study are to examine whether a continuous interscalene block of a total duration of 48 hours reduces the incidence of rebound pain comparatively to single-shot interscalene block, through…
- Conditions
- Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Interscalene Analgesia, Interscalene Blocks
- Trial name
- NCT07770165
- Testing
- Continuous interscalene nerve block, Interscalene Block
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- University of Calgary
Migraine, Migraine Headache
Neuromodulation During the Prodrome to Prevent Disabling Migraine Attacks in Youth
Background \& Rationale: One in ten Canadian youth have migraine, a disabling neurological disease that is more common in females and characterized by moderate-severe disabling headaches.
- Trial name
- NCT07772427
- Testing
- Active Remote Electrical Neuromodulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary