Clinical trials: sponsored by University of Calgary
Vasovagal Syncope
Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope
Objective: To determine if atomoxetine 40 mg bid (bis in die) in patients ≥18 years old with recurrent vasovagal syncope will better prevent syncope during tilt testing than placebo.
- Trial name
- POST6 (NCT02500732)
- Testing
- Atomoxetine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Sarcopenia, Critical Illness
ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma
Using abdominal computed tomography (CT) imaging, the investigators will estimate total body muscle mass at two time points in Intensive Care Unit (ICU) by assessing cross-sectional muscle areas at the L3 vertebral body level.
- Conditions
- Sarcopenia, Critical Illness, Sepsis, Trauma
- Trial name
- NCT03982628
- Testing
- Abdominal CT imaging
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University of Calgary
Sarcopenia, ICU Acquired Weakness
ICU Associated Weakness and Bedside Ultrasound Assessment
ICU-associated weakness is a common experience for people following a critical illness. It is associated with important patient and system-relevant outcomes.
- Trial name
- NCT04095533
- Testing
- Tibialis anterior muscle cross-sectional area assessment by ultrasound, Muscle strength assessment
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Urinary Stress Incontinence
Mid-Urethral Sling Tensioning Trial
Prospective randomized clinical trial comparing two methods of intra-operative tensioning of retropubic midurethral slings for stress urinary incontinence. Primary outcome is rate of abnormal bladder function.
- Trial name
- MUST (NCT02480231)
- Testing
- Retropubic Midurethral Sling
- Where
- Canada
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Osteoarthritis, Knee, Arthroscopy
Evaluating the Effectiveness of Subchondroplasty for Treating Bone Marrow Lesions of the Knee
The primary objective of this randomized pilot study is to evaluate whether subchondroplasty combined with knee arthroscopy is more effective at reducing knee pain and improving knee function compared to knee arthroscopy alone.
- Conditions
- Osteoarthritis, Knee, Arthroscopy, Musculoskeletal Disease, Bone Marrow Edema
- Trial name
- NCT03699046
- Testing
- Subchondroplasty and Knee Arthroscopy, Knee Arthroscopy Alone, Subchondroplasty
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Tonsillectomy
Tonsillectomy Using BiZact Tonsilletomy Device
The purpose of this study is to describe how Bizact Tonsillectomy Device might affect operative time and intraoperative blood loss in pediatric patients undergoing tonsillectomy, and compare these parameters to the standard…
- Trial name
- NCT04320095
- Testing
- Bizact tonsillectomy device
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pulmonary Hypertension
Upfront Combination Pulmonary Arterial Hypertension Therapy
To evaluate the safety and efficacy of first-line combination therapy using riociguat with ambrisentan in patients with Pulmonary Arterial Hypertension (PAH).
- Trial name
- NCT03809156
- Testing
- Riociguat Oral Product
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Cognitive Change, Behavior
Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children
The demand for magnetic resonance imaging (MRI) in pediatric patients is increasing due to its use in medical diagnosis and surveillance.
- Trial name
- NCT03022240
- Testing
- Propofol, Sevoflurane, Ametop
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Developmental Coordination Disorder
Does tDCS Improve Motor Learning in Children With DCD?
Transcrainial direct current stimulation (tDCS) has become increasingly popular over the past decade. tDCS is a safe and well-studied form of non-invasive brain stimulation.
- Trial name
- NCT03453983
- Testing
- Transcrainial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Calgary
Ineffective Esophageal Motility, Dysphagia
Treatment of Dysphagia and Ineffective Esophageal Motility With Prucalopride: A Pilot Study
This study will test prucalopride (a prokinetic drug currently approved by Health Canada for treatment of constipation) as a treatment for Ineffective Esophageal Motility (IEM).
- Trial name
- IEMPru (NCT03244553)
- Testing
- Prucalopride
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Tourette Syndrome
tDCS in Tourette (TIC-TDCS)
Double-blind randomized, sham-controlled clinical trial of 1 mA bilateral supplementary motor area in adolescents/adults with Tourette syndrome (TS).
- Trial name
- TIC-TDCS (NCT03401996)
- Testing
- 1 mA tDCS over bilateral SMA
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Multiple Sclerosis, Secondary Progressive
Domperidone in Secondary Progressive Multiple Sclerosis (SPMS)
The purpose of this clinical trial is to determine if Domperidone in a dose of 40 mg daily can prevent worsening of walking ability in people secondary progressive MS. The number of participants in this study will be 62.
- Trial name
- NCT02308137
- Testing
- Domperidone
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Benign Prostatic Hyperplasia
Evaluate the Safety and Effectiveness of Using Echogenic Embolic Agent for Embolization of Prostate Artery for Treatment of Men With BPH (PAE CEUS)
A prospective single centre study to evaluate the safety and effectiveness of using contrast enhanced ultrasound and echogenic embolic agent Ekobi Embolization Microspheres in Prostate Artery Embolization for the Treatment of Men…
- Trial name
- PAE CEUS (NCT04267445)
- Testing
- Embolization of prostatic artery under ultrasound guidance
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Obesity
Evaluation of Pulse Fibre Supplementation on Obesity and the Metabolic Syndrome
The recent dramatic increase in obesity has been linked to a reduction of dietary fibre intake. We hypothesized that supplementing the diet of overweight and obesity adults with pulse fibre will improve their metabolic status…
- Trial name
- NCT01719900
- Testing
- Pulse fibre, Control
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hemiplegic Cerebral Palsy, Perinatal Stroke
Robotic Rehabilitation and Brain Stimulation for Children With Hemiparetic Cerebral Palsy
This study evaluates the use of robotic rehabilitation with and without transcranial direct current stimulation (tDCS) to improve motor performance in children with hemiparetic cerebral palsy.
- Trial name
- RoboCP (NCT04233710)
- Testing
- Robot Rehabilitation + tDCS
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Acute Pain
Virtual Reality Use for Peri-Procedural Analgesia and Anxiolysis
Currently, most analgesic regimens for painful bedside procedures rely on pharmacologic sedation or high doses of opioids (e.g.: nurse-administered IV opioids, anxiolytics, and sedatives; patient-controlled analgesia…
- Trial name
- NCT04218396
- Testing
- Virtual Reality use during painful bedside procedure, Standard Treatment during painful bedside procedure
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Body-dissatisfaction
Cognitive Dissonance and Attentional Biases Related to Body Dissatisfaction
The purpose of this study is to assess a cognitive dissonance-based eating disorder prevention intervention program on its ability to reduce attentional biases in body-dissatisfied women.
- Trial name
- NCT03219814
- Testing
- The Body Project, Mediapsychoeducation
- Where
- Canada
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke
Robot-Enhanced Stroke Therapy Optimizes Rehabilitation (RESTORE)
The purpose of this study is to investigate two aspects of robotic therapy after stroke. One goal is to determine if early robotic rehabilitation of the upper limb (beginning 5-9 days post-stroke) is more effective than later…
- Trial name
- RESTORE (NCT04201613)
- Testing
- Robotic exoskeleton, Usual Care
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- University of Calgary
Spinal Cord Injuries, Autonomic Dysreflexia
Spinal Cord Stimulation and Autonomic Response in People With SCI.
Despite being studied less than half as frequently, autonomic dysfunction is a greater priority than walking again in spinal cord injury.
- Conditions
- Spinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT03924388
- Testing
- Epidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
- Where
- 2 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of Calgary
Anxiety, Depression
Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT) Full Trial
We hypothesize that the intervention will: (1) offer a feasible approach for providing mental healthcare to pregnant women and have a high level of acceptability by pregnant women and healthcare providers; (2) reduce symptoms of…
- Trial name
- NCT01901796
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary