Clinical trials: sponsored by University of Calgary
Mild Traumatic Brain Injury, Post-Concussion Syndrome
Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury
A substantial number of children and adolescents sustain a mild traumatic brain injury (mTBI) each year. Although research supports that the vast majority of youth will recover quickly and return to normal functioning, some…
- Conditions
- Mild Traumatic Brain Injury, Post-Concussion Syndrome, Insomnia
- Trial name
- NCT03688984
- Testing
- Cognitive Behavioural Therapy for Insomnia
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Insomnia
Open Pilot of Cognitive Behavioural Therapy for Insomnia in Pregnancy
Despite the literature showing cognitive behavioural therapy for insomnia (CBT-I) to be effective in a variety of populations including postpartum women, as well as the demonstrated harmful consequences of sleep disturbances in…
- Trial name
- NCT02295345
- Testing
- Cognitive Behavioural Therapy for Insomnia
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Calgary
Depression, Anxiety
Mindfulness Based Cognitive Therapy for Psychological Distress in Pregnancy
Anxiety, stress and depression are common during pregnancy and in the postpartum period. The lack of empirically supported, non-pharmaceutical interventions for psychological distress in pregnancy is a significant gap in the…
- Conditions
- Depression, Anxiety, Stress
- Trial name
- NCT02214732
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- 2 sites in Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Insomnia, Sleep Disturbance
Sleeping for Two: RCT of CBT-Insomnia in Pregnancy
Cognitive-behavioural therapy for insomnia (CBT-I) has been shown to be an effective treatment for insomnia in multiple populations, including women during pregnancy and postpartum.
- Trial name
- NCT03301727
- Testing
- Cognitive-Behavioural Therapy for Insomnia (CBT-I)
- Where
- 2 sites in Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Depressive Disorder, Treatment-Resistant
Biomarkers of Theta Burst Stimulation in Major Depressive Disorder
This study investigates the brain-based biomarkers of treatment response to accelerated theta burst stimulation (aTBS) in patients with Major Depressive Disorder resistant to pharmacological treatment(MDD) in an open label design.
- Trial name
- NCT03626181
- Testing
- Theta Burst Stimulation ( Transcranial Magnetic Stimulation)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Obesity, Weight Loss
Bariatric Embolization Trial for the Obese Nonsurgical
The purpose of this study is to assess the safety profile of bariatric embolizations and confirm published reports of sustained post-procedural weight loss, and pathologically assess post-procedural metabolic effects.
- Conditions
- Obesity, Weight Loss, Body Weight, Morbid Obesity
- Trial name
- BET-ON (NCT03601273)
- Testing
- Left gastric artery embolization
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hypertension, Pulmonary
First-line Bosentan and Sildenafil Combination Therapy for Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the strategy of initiating double oral combination therapy with bosentan and sildenafil at the time of diagnosis of pulmonary arterial hypertension (PAH) in a preliminary way.
- Trial name
- NCT01247116
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Pleural Effusions Post Coronary Artery Bypass Graft
Necessity of Using Pleural Drainage Tubes After IMA Harvesting During Cardiac Surgery
This prospective randomized controlled trial will examine the efficacy of reducing the number of chest tubes used in the postoperative cardiac surgery patient.
- Trial name
- NCT02147821
- Testing
- No Pleural Chest Tube
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- University of Calgary
Necrotizing Enterocolitis
SMA Flow Patterns in Neonatal Transfusion
This study aims to measure the changes induced by packed red blood cell (PRBC) transfusion in the superior mesenteric artery (SMA) flow velocity and intestinal oxygenation indices in premature neonates.
- Trial name
- SPARTAN (NCT02347475)
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Calgary
Cervical Cancer Screening
Post Colposcopy Management of ASC-US and LSIL Pap Tests
There is weak evidence supporting optimal follow-up of women with ASC-US or LSIL cytology found to have low grade disease or normal findings at initial colposcopy.
- Trial name
- NCT03466710
- Testing
- Colposcopy, Pap test, HPV test
- Volunteers
- 133 people
- Sponsor
- University of Calgary
Neuromyelitis Optica
Autologous Hematopoietic Stem Cell Transplant in Neuromyelitis Optica
Neuromyelitis Optica (NMO) is a demyelinating and degenerative disorder of the CNS affecting vision and spinal cord function. This disease is rare compared to Multiple Sclerosis (MS), but it is devastating and often leads to…
- Trial name
- SCT-NMO (NCT01339455)
- Testing
- AHSCT
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Calgary
Central Venous Catheterization
Umbilical Venous Catheter Insertion Depth in Neonates
In this randomized clinical study, neonates who require umbilical venous catheter (UVC) insertion as part of their routine care at anytime during their NICU admission will be randomized to one of the 2 formulas for estimation of…
- Trial name
- NCT02939690
- Testing
- UVC, Ultrasound
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Oral Squamous Cell Carcinoma or Severe Dysplasia
Fluorescent Visualization in Early Oral Cancer
Studies from Vancouver show that fluorescent visualization (FV) is a useful method of controlling surgical margins. This early finding will now be confirmed in a national randomized controlled trial.
- Trial name
- NCT02306967
- Testing
- resection of oral cancer
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Joint Contractures
Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures
Injured joints, especially at the elbow, are at risk for permanent motion loss, also known as joint contractures. Joint contractures limit the function of an elbow and are a recognized complication that occurs often after a…
- Trial name
- Ketotifen (NCT01902017)
- Testing
- Ketotifen
- Where
- 3 sites in Canada
- Volunteers
- 152 people
- Sponsor
- University of Calgary
Parenteral Nutrition Associated Liver Disease
Olive Oil and Soybean 1 Oil Based Intravenous Lipid Emulsions, Liver Chemistry and Clinical Outcomes
Background: Intravenous lipid emulsions (IVLE) are an essential component of parenteral nutrition (PN). Omega-6 reducing strategies may improve outcomes, including reduced PN associated liver disease.
- Trial name
- NCT03442361
- Volunteers
- 206 people
- Sponsor
- University of Calgary
Obesity, Abdominal Obesity
Application of the SIMPLE Program for Weight Loss at Pathways to Housing: A Feasibility Study
The objective of this study is to assess feasibility of the application of an adapted version, with permission, of Dr. Cenk Tek's Simplified Intervention to Modify Physical activity, Lifestyle, and Eating behavior (SIMPLE…
- Trial name
- NCT03389425
- Testing
- simplified intervention to modify physical activity, lifestyle, and eating behavior
- Volunteers
- 9 people
- Sponsor
- University of Calgary
Wounds and Injuries
One-year Patient Reported Outcomes Following Hospitalization for Trauma
This study evaluates the three, six, and twelve month patient reported outcomes of people admitted two trauma centres in western Canada over a four month period.
- Trial name
- NCT02909231
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Iron Deficiency Anemia
Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding
The role of capsule endoscopy (CE) in patients with obscure / occult gastrointestinal (GI) bleeding remains unclear. This pragmatic randomized controlled trial is designed to determine the diagnostic yield and clinical outcomes…
- Trial name
- NCT00694954
- Testing
- Diagnostic Test - Given Imaging Pillcam, Diagnostics
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of Calgary
Obscure Gastrointestinal Bleeding
Capsule Endoscopy in Obscure GI Bleeding
The purpose of this study is to conduct a cost-effectiveness analysis of wireless capsule endoscopy in the investigation of patients with overt obscure gastrointestinal bleeding.
- Trial name
- NCT00203619
- Testing
- Wireless capsule endoscopy, standard care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Laparoscopic Surgical Procedures
Enhancing Laparoscopic Skill Acquisition and Retention With Transcranial Direct-current Stimulation
Recent changes in medical training environments and restrictive work-hour regulations have greatly impacted trainees, limiting the number of opportunities to gain proficiency in procedural skills.
- Trial name
- NCT02756052
- Testing
- Anodal Transcranial direct-current stimulation
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Calgary