Clinical trials: sponsored by University of Calgary
Amyotrophic Lateral Sclerosis (ALS)
A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that results in rapid decline in normal muscle function and tone leading to difficulties with mobility, eating, drinking, breathing, sleeping, and communicating.
- Trial name
- NCT02463825
- Testing
- Pimozide 2 mg per day, Pimozide 4 mg per day
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Parental Comprehension of Informed Consent
The Train Study: Parental Understanding of Informed Consent
Project Summary: One of the challenges facing pediatric researchers is the need to balance decreasing funding with the time and human resource costs associated with enrolling children.
- Trial name
- TRAIN (NCT01994447)
- Testing
- Student Enrollment
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Type 2 Diabetes
The Diabetes Aerobic and Resistance Bands Exercise (DARE-Bands) Trial
BACKGROUND Resistance exercise training with free weights or weight machines clearly improves glucose (sugar) control in type 2 diabetes (T2D).
- Trial name
- DARE-Bands (NCT02009995)
- Testing
- Aerobic Training (AT), AT plus Primarily Home-Based Resistance Band Training
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University of Calgary
Resuscitation
Effect of Establishing Functional Residual Capacity During Newborn Resuscitation on Oxygenation
Currently, newborns receive 100% supplemental oxygen by free flow when they remain cyanotic despite demonstrating regular respiratory effort.
- Trial name
- NCT00531102
- Testing
- continuous positive airway pressure, Free flow oxygen
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Asthma, Education
Implementation of a Pediatric-to-adult Asthma Transition Program
Despite the clear and often stated need, a formal transition program does not exist for asthma patients as they move from pediatric to adult care in Western Canada. This population is not having their health care needs met.
- Trial name
- NCT01521247
- Testing
- Asthma Transition Program
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Rheumatoid Arthritis, Osteoarthritis
Low Dose Dexamethasone in Supraclavicular Blocks
Brachial plexus nerve blocks provide superior analgesia over opioids while avoiding unwanted side effects. Single shot blocks with local anesthetic alone usually do not last the duration of the acute post-surgical pain period.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Nerve Entrapment, Ligament Injury
- Trial name
- NCT02666443
- Testing
- Control intervention (no dexamethasone), Peri-neural Dexamethasone 1 mg, Intravenous Dexamethasone 1 mg
- Where
- Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University of Calgary
End Stage Renal Failure on Dialysis
Comparing Nutritional Status of In-centre Nocturnal Hemodialysis Patients to Conventional Hemodialysis Patients
Although hemodialysis is life-saving, unfortunately, people on dialysis often have declining health, quality of life as well as poor nutritional status.
- Trial name
- NCT02887391
- Testing
- No intervention - observational study
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Stress Urinary Incontinence
Trans-Obturator Tape Versus Trans-Vaginal Tape for Stress Urinary Incontinence in Women
Stress urinary incontinence (SUI) is a health concern for many women. The transvaginal tape (TVT) surgery has become a common procedure to address the problem. Another surgery is now available, trans-obturator tape (TOT).
- Trial name
- NCT00234754
- Testing
- TVT Surgery TOT Surgery
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- University of Calgary
Urinary Incontinence, Stress
Transvaginal Tape (TVT) Secur Versus TVT Randomised Controlled Trial (RCT)
This randomized multi-centre trial will recruit women with stress urinary incontinence who need surgical treatment for their condition.
- Trial name
- NCT00685217
- Testing
- TVT Secur (Gynecare), TVT (Gynecare)
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Cardiovascular Disease, Sudden Cardiac Death
Vitamin D and Cardiac Autonomic Tone in Hemodialysis
Despite advances in treatment of conventional cardiovascular risk factors, patients with kidney disease remain at high risk for fatal cardiac events.
- Trial name
- VITAH (NCT01774812)
- Testing
- Alfacalcidol, Ergocalciferol
- Where
- 3 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University of Calgary
Lung Nodules
Bronchoscopic Approach to the Peripheral Lung Nodule - Endobronchial Ultrasound, Electromagnetic Navigation and Cryobiopsy
In patients with peripheral lung nodules, what is the additional diagnostic yield of biopsies obtained with flexible cryoprobes compared to standard techniques? For patients with peripheral nodules, we hypothesize use of the…
- Trial name
- NCT02196974
- Testing
- cryobiopsy
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Calgary
Anterior Pelvic Organ Prolapse
Trial of Small Intestine Submucosa (SIS) Mesh for Anterior Repair: A Pilot Study
Prolapse occurs when pelvic organs drop down and cause a bulging of the tissues. An "anterior wall prolapse" occurs when the front of the vagina loses its support, and the bladder drops down and rotates into the vaginal opening.
- Trial name
- Anterior SIS (NCT00955448)
- Testing
- SIS mesh (Cook Medical), Anterior prolapse repair
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Patent Ductus Arteriosus
An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants
A large patent ductus arteriosus (PDA) is associated with congestive heart failure, pulmonary hemorrhage, chronic lung disease (CLD), necrotizing enterocolitis (NEC) and intraventricular bleeding.
- Trial name
- NCT00750581
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Inflammatory Bowel Disease
Comparison of Surveillance Colonoscopy Techniques in Patients With IBD
We propose a randomized controlled study to determine the detection rates of neoplasia with high definition colonoscopy alone, high definition dye spraying chromoendoscopy or High definition iSCAN virtual chromoendoscopy in…
- Trial name
- NCT02098798
- Testing
- HD Colonoscopy, HD Colonoscopy + iSCAN, HD Colonoscopy + dye spray
- Where
- Canada
- Volunteers
- 270 people
- Sponsor
- University of Calgary
Myocardial Infarction, Death, Sudden, Cardiac
Assessment of Noninvasive Methods to Identify Patients at Risk of Serious Arrhythmias After a Heart Attack
This study evaluates the usefulness of noninvasive tests of the structure of the heart and the nervous system controlling the heart.
- Conditions
- Myocardial Infarction, Death, Sudden, Cardiac, Death
- Trial name
- NCT00399503
- Testing
- Spectral T Wave Alternans, Modified Moving Average T Wave Alternans, Baroreceptor Sensitivity
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- University of Calgary
Head and Neck Cancer
PET/CT: Role in Detecting Unknown Primary Head and Neck Cancer
Historically metastatic squamous cell carcinoma in a cervical lymph node from an occult primary malignancy of the head and neck was evaluated with panendoscopy and biopsies of high risk areas, such as the base of tongue…
- Trial name
- NCT00656760
- Testing
- PET/CT
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Bipolar Disorder
A Trial of Cognitive Training in Euthymic Bipolar Disorder
Bipolar disorder (BD) is characterized by extreme changes in mood and emotion dysregulation. Mood changes are episodic in nature, with distinct periods of mania, depression, and asymptomatic periods of euthymia.
- Trial name
- NCT02476331
- Testing
- Working memory training
- Where
- Canada
- Sponsor
- University of Calgary
Inflammatory Bowel Disease
Infliximab IBD Influenza Vaccine Study
The investigators will compare the immunogenicity of influenza vaccine in adults and children with inflammatory bowel disease by timing of vaccine in relation to maintenance infliximab dosing.
- Trial name
- NCT01666535
- Testing
- Influenza vaccination
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of Calgary
Cancer
An Investigation of Light Therapy for Cancer-related Fatigue (The LITE Study)
Cancer-related fatigue is one of the most common and distressing symptoms associated with a cancer diagnosis.Fatigue related to cancer often appears before a diagnosis, worsens during treatment, and lasts for years after…
- Trial name
- LITE (NCT01780623)
- Testing
- Bright white light, Dim red light
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- University of Calgary