Clinical trials: sponsored by University of Calgary
Allergic Contact Dermatitis
Reliability of Expired Allergens in Patch Testing: A Comparative Study With Non-Expired Series
Patch testing remains the gold standard in the diagnosis of allergic contact dermatitis. Patches used in testing consist of a wide spectrum of allergens, with variability in the stability of products over time.
- Trial name
- NCT07765563
- Testing
- Patch 1 (Expired), Patch 2 (non-expired)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Alveolar Soft Part Sarcoma (ASPS), Sarcoma
A Study to Determine the Safety and Effectiveness of the Investigational Cellular Therapy GCAR1 in a Patient With Alveolar Soft Part Sarcoma
A single patient study to determine whether GCAR1 is safe and effective for refractory, progressive metastatic alveolar soft part sarcoma (ASPS).
- Trial name
- SPS-C (NCT07104682)
- Testing
- GCAR1
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Elbow Fracture, Elbow Injury
PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2
PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) is a Phase III randomized, controlled, double blinded multicenter trial with 3 parallel groups (Ketotifen 2 mg or 5 mg or lactose placebo twice daily orally for 6…
- Conditions
- Elbow Fracture, Elbow Injury, Elbow Dislocation
- Trial name
- PERK2 (NCT03582176)
- Testing
- Ketotifen Fumarate 2mg, Ketotifen Fumarate 5mg
- Where
- 15 sites in United States, Canada
- Volunteers
- 395 people
- Sponsor
- University of Calgary
Children Unable to Walk Independently
Upright Participation for Learners: Implementation of Flexible Use of roboT-assisted Walking in Schools - PILOT
Robot-assisted walking offers children who are unable to walk new avenues for participation in their communities in addition to health benefits. Disappointingly, most children cannot access this impactful technology.
- Trial name
- UPLIFTS Pilot (NCT07726706)
- Testing
- Robotic walking
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Tourette Syndrome
Transcranial Ultrasound Stimulation for Tourette Syndrome
This is a phase 1 clinical trial investigating the use of low-energy Transcranial Ultrasound Stimulation (TUS) to treat Tourette Syndrome (TS). Objectives and Background.
- Trial name
- TUS-TS (NCT07699783)
- Testing
- Focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Coronary Disease, Stroke
Assessing Outcomes of Enhanced Chronic Disease Care Through Patient Education and a Value-based Formulary Study
The purpose of this study is to determine the effect of two novel interventions; (1) a value-based formulary which eliminates copayment for selected high-value medications (proven to prevent heart attacks, stroke, and…
- Conditions
- Coronary Disease, Stroke, Chronic Kidney Disease, Heart Failure
- Trial name
- ACCESS (NCT02579655)
- Testing
- Copayment Elimination, Personalized Education
- Where
- Canada
- Volunteers
- 4,764 people
- Sponsor
- University of Calgary
Diet, Healthy, Diabetes Mellitus, Type 2
Healthy Food Prescription Incentive Program
It is important for individuals with type 2 diabetes (T2DM) to adhere to a healthy dietary pattern to maintain optimal blood glucose levels and overall health.
- Conditions
- Diet, Healthy, Diabetes Mellitus, Type 2, Diabetes Complications
- Trial name
- NCT04725630
- Testing
- Healthy food incentive, Healthy food prescription
- Where
- Canada
- Volunteers
- 597 people
- Sponsor
- University of Calgary
Breast - Female
Feasibility of Comparing Microwave Images to Clinical Information in Patients Recalled for Follow-up Breast Imaging
The goal of this clinical trial is to measure the electrical properties of breast tissues using microwave technology and to compare these collected measurements to clinical information in mammograms and/or breast ultrasound for…
- Trial name
- NCT07273565
- Testing
- WVI-MIS-02-2025
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Breast - Female
Feasibility of Imaging Breast Implants With a Transmission-based Microwave Scanner
The goal of this clinical trial is to assess whether microwave scans can depict the presence of implants in the breast in women with existing breast implants that were surgically placed at least 6 months ago.
- Trial name
- NCT07487792
- Testing
- WVI-MIS-03-2025
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Prediabetes or Diabetes, Surgery Complications
The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes
The goal of this study is to measure the prevalence and risks of hyperglycemia in surgical patients with prediabetes. The main questions it aims to answer are: What is the prevalence of hyperglycemia in surgical patients with…
- Conditions
- Prediabetes or Diabetes, Surgery Complications, Non-Cardiac/ Non-Thoracic Surgery, Stress Hyperglycemia
- Trial name
- NCT07662980
- Where
- Canada
- Volunteers
- 750 people
- Sponsor
- University of Calgary
Anxiety and Depression
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression
This is a parallel arm randomized (1:1) controlled trial. Adolescents aged 12-17 years (n=228) who are starting or changing a selective serotonin reuptake inhibitor (SSRI) for depression and/or anxiety will be randomly allocated…
- Trial name
- PGx-GAP (NCT06853587)
- Testing
- Pharmacogenetic-guided dosing, Current prescribing guidelines/recommendations
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- University of Calgary
Cesarean Section Complications, Pain, Postoperative
Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.
The purpose of this research study is to evaluate whether or not adding a Transversus Abdominis Plane Block (TAP block) improves pain control for patients having a cesarean section.
- Trial name
- NCT06324942
- Testing
- Surgeon-administered Transversus Abdominis Plane Block 0.25% bupivicaine 0.25 mL/kg
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cancer
EXCEL-Punjabi: A Culturally Tailored Exercise Oncology Pilot Feasibility Intervention
The goal of this pilot feasibility study is to explore the feasibility and exploratory effects of a culturally-tailored exercise oncology intervention in Punjabi-speaking individuals of South Asian heritage and their support…
- Trial name
- EXCEL-Punjabi (NCT07643389)
- Testing
- EXCEL-Punjabi
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Mild Traumatic Brain Injury, Headaches Posttraumatic
SMART Concussion Trial: Symptom Management vs Alternative Randomized Treatment of Concussion Trial
Given the rising rates of concussion in youth ages 10-19 and the significant proportion of young people who remain symptomatic for months following concussion, research evaluating the efficacy of multifaceted treatment options…
- Conditions
- Mild Traumatic Brain Injury, Headaches Posttraumatic, Neck Pain, Dizziness
- Trial name
- SMART (NCT05446597)
- Testing
- Symptom-specific Headache Treatment, Symptom-specific Dizziness &/or Neck Pain Treatment, Multimodal Concussion Treatment
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Coronary Artery Bypass Graft (CABG), Chest Tubes
Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery
Background: After heart surgery, patients require temporary chest tubes - plastic drains placed inside the chest to prevent fluid building up around the heart and lungs.
- Conditions
- Coronary Artery Bypass Graft (CABG), Chest Tubes, Post Operative Pain Control
- Trial name
- FREEZE-B (NCT07643506)
- Testing
- 0.5% Bupivacaine without epinephrine, 10cc injection of normal saline (0.9%)
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome
Hamstring Strengthening in Hypermobile Conditions
The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).
- Conditions
- Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome
- Trial name
- NCT07626957
- Testing
- Progressive resistance exercise with an emphasis on eccentric hamstring loading.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Atrial Fibrillation, Post-cardiac Surgery
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients
Post-operative atrial fibrillation is a common problem post cardiac surgery with rates exceeding 30%. Atrial fibrillation has multiple adverse effects on cardiac hemodynamics and can lead to hypotension, diminished end organ…
- Trial name
- NCT04748991
- Testing
- Vernakalant, Amiodarone
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Osteo Arthritis Knee, Analgesia
Comparing Local Anesthesia With and Without iPACK Block
Total knee arthroplasty is an effective surgical intervention for patients with chronic osteoarthritis commonly performed worldwide. Postoperative pain management has been a key focus in patient care for this procedure.
- Conditions
- Osteo Arthritis Knee, Analgesia, Pain, Postoperative
- Trial name
- NCT04635176
- Testing
- Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Papillary Thyroid Cancer, Papillary Thyroid Carcinoma
Clinical Utility of Preoperative Thyroid GuidePx® Testing
The purpose of this study is to learn whether having Thyroid GuidePx® test results available before treatment may help patients with papillary thyroid cancer and doctors make better-informed treatment decisions.
- Trial name
- NCT07584447
- Volunteers
- 85 people
- Sponsor
- University of Calgary