Clinical trials: sponsored by University of Calgary
Child Mortality, Maternal Mortality (All Cause)
MNCH Programming in Southwest Uganda Maternal and Child Health In Bushenyi and Rubirizi Districts, UGANDA
The investigators will assess whether in Bushenyi District in southwestern Uganda, a two year intervention providing comprehensive MNCH programming will: Reduce morbidity and mortality for children under five years old and…
- Trial name
- HCUM (NCT01571765)
- Testing
- MNCH programming in health district
- Where
- Uganda
- Volunteers
- 10,985 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Ischemic Stroke
Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke
The purpose of the study is to understand whether a new treatment of stroke - endovascular clot removal - can be added to the current standard of care to improve patient outcomes.
- Trial name
- ESCAPE (NCT01778335)
- Testing
- Endovascular thrombectomy/thrombolysis
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- University of Calgary
Fractures, Comminuted, Fracture Fixation, Internal
Comparative Study of Fixation or Fusion of Calcaneal Fractures
A multicentre randomized controlled trial that will be conducted at Level 1 trauma centres across Canada. It will compare patients who receive open reduction, internal fixation for Sanders IV calcaneal fractures to patients who…
- Trial name
- Sanders IV (NCT00679393)
- Testing
- Open reduction internal fixation, Fusion
- Where
- 4 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Obstetric Labor, Premature
Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor
Prematurity remains the most important single factor in perinatal morbidity and mortality. Unfortunately, the rate of premature delivery is increasing in Canada and is especially high in Alberta with 7.5% of pregnancies ending…
- Trial name
- PROTO (NCT01286246)
- Testing
- Vaginal progesterone
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Calgary
Major Depressive Disorder
Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis
Despite significant advances in pharmacological treatment, the global burden of depression is increasing worldwide. The major challenge in antidepressant treatment is the clinicians' inability to predict the variability in…
- Trial name
- NCT02330679
- Testing
- Desvenlafaxine
- Where
- 2 sites in Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Atrial Fibrillation
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins
The purpose of this study is to determine the effect of statin therapy for prevention of atrial fibrillation (AF) in pacemaker and non-pacemaker patients with paroxysmal atrial fibrillation in the absence of significant coronary…
- Trial name
- PAFRIOSIES (NCT00321802)
- Testing
- Simvastatin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Migraine
Changes in Intracranial Compliance in Migraine Subjects Following a National Upper Cervical Chiropractic Association Atlas Correction
A small number of chiropractors, who align only the atlas C-1, or "top" vertebra in the spine, practice the National Upper Cervical Chiropractic Association (NUCCA) atlas correction procedure.
- Trial name
- NCT01980927
- Testing
- NUCCA atlas correction
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Internet Data Collection
Does Internet Data Collection Improve Cohort Retention?
One of the biggest challenges of conducting research where the investigators follow people over a long period of time is keeping the participants involved.
- Trial name
- NCT01740674
- Testing
- Electronic data collection
- Where
- Canada
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pituitary Adenoma, Posterior Septectomy
Comparison of Surgical Approach to Endoscopic Pituitary Adenoma Resection
The purpose of this study is to determine if there is a significant difference in sinonasal disease specific quality of life and utility scores between patients undergoing the posterior septectomy or Stamm approach during…
- Conditions
- Pituitary Adenoma, Posterior Septectomy, Stamm Approach, Quality of Life
- Trial name
- NCT01689064
- Testing
- Stamm Approach, Posterior Septectomy
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of Calgary
Chronic Sinusitis, Endoscopic Sinus Surgery
Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery
Chronic rhinosinusitis (CRS) is an inflammatory condition of the nose and sinuses. It affects about 5 to 10% of Canadians. Patients suffer from congestion in the nose and sinuses, nasal discharge, pressure in the face, and a…
- Conditions
- Chronic Sinusitis, Endoscopic Sinus Surgery, Post-operative Care, Steroids
- Trial name
- NCT01564355
- Testing
- Steroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid), Post-op Oral Steroids
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
Coronary Artery Disease, Acute Coronary Syndrome
Does Montelukast Have an Affect on the Function of the Artery in Patients With Heart Disease
To evaluate the effect of the drug Montelukast on the brachial artery's function. By giving a drug like Montelukast, which blocks the effects of inflammation in the lungs arteries and controls asthma, we hope to see positive…
- Trial name
- NCT00351364
- Testing
- Montelukast Sodium
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Aging, Physical Activity
Exercise Intervention and Running Biomechanics in Older Adults
The goal of this study is to understand the effects of muscle strengthening and stretching exercise intervention on isometric muscle strength, joint flexibility and running biomechanical patterns in older recreational runners.
- Trial name
- NCT01574794
- Testing
- Muscle strengthening exercises, Muscle stretching exercise
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Oral Cavity Squamous Cell Carcinoma, Treated With Surgery
Does the Harmonic Scalpel Reduce Blood Loss and OR Time in Major Head and Neck Cancer Surgery Undergoing Major Surgery for Oral Cavity Squamous Cell Carcinoma?
The harmonic scalpel is a tool that may reduce operative blood loss. Some studies also indicate it may result in faster surgery.
- Trial name
- HS2 (NCT02017834)
- Testing
- surgical resection
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Calgary
Prodromal Schizophrenia
Effects of Cognitive Remediation on Cognition in Young People at Clinical High Risk of Psychosis
Onset of psychotic disorders such as schizophrenia, typically occurs during late adolescence or early adulthood often resulting in chronic social and occupational disability.
- Trial name
- NCT01619319
- Testing
- Cognitive Remediation Therapy, computer games
- Volunteers
- 32 people
- Sponsor
- University of Calgary
Type 1 Diabetes
Comparison of a Twice Daily Versus a Three Times Daily Insulin Regimen in Children With Type 1 Diabetes
The purpose of this study is to determine whether there is a difference in blood sugar control (as measured by hemoglobin A1c (HA1c)), in children given twice daily insulin injections incorporating a new long acting insulin…
- Trial name
- NCT00522210
- Testing
- Detemir, Novolin NPH or Humulin N
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Obesity
Family Intervention for Obese Children Using Portion Control Strategy for Weight Control
Obesity in children is a serious disease that is associated with increased mortality and decreased life expectancy. A simple tool used to assist in controlling portions (and therefore calorie intake) at mealtime would be of…
- Trial name
- FOCUS (NCT00881478)
- Testing
- Nutrition counseling + portion control tool, Nutrition counseling
- Where
- Canada
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Type 2 Diabetes
Motivational Interviewing to Promote Maintenance of Physical Activity in People With Type 2 Diabetes
The purpose of the study is to assess the effectiveness of motivational interviewing in promoting maintenance of physical activity in people with Type 2 diabetes (T2D) upon the completion of a structured exercise program.
- Trial name
- NCT01067924
- Testing
- Motivational interviewing
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of Calgary
Hysterectomy
Post Hysterectomy Pain Prevention: Pre-op Wound Infiltration With Anesthetic Protocol Versus Standard of Care
The study is a blinded randomized clinical trial, comparing policies of high volume preemptive wound infiltration with a specific anesthetic cocktail versus standard of care (no wound infiltration and routine anesthesia) for post…
- Trial name
- NCT01627353
- Testing
- Standard of care, Pre-emptive wound infiltration
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Calgary
Hypotension
Blood Pressure Guided Biofeedback on Hemodialysis and the Reduction of IntraDialytic Hypotension
It is very common for hemodialysis patients to have problems with low blood pressure while on hemodialysis. Low blood pressure on dialysis is not a good thing and it is associated with an increased risk of death and…
- Trial name
- BP-RIDH (NCT01749761)
- Testing
- BioLogic RR, Hemodialysis without biofeedback
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Major Depressive Disorder
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression
Major depressive disorder (MDD) is a highly prevalent, chronic and/or recurrent condition with substantial morbidity and mortality. It is one of the leading causes of disability worldwide.
- Trial name
- NCT02132286
- Testing
- Quetiapine XR (extended release)
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary