Clinical trials: sponsored by University of Calgary
Multiple Sclerosis, Optic Neuritis
Neuroprotection and Repair in Optic Neuritis
The primary aim of this open-label pilot trial is to estimate the treatment effect of 100 mg of oral minocycline twice daily for 90 days, initiated within 30 days of onset of ON, on functional and structural optic nerve recovery…
- Trial name
- Mino in ON (NCT01073813)
- Testing
- Minocycline
- Volunteers
- 6 people
- Sponsor
- University of Calgary
Pulmonary Embolism, Diagnostic Uncertainty
The Visualization of Uncertainty in Clinical Diagnostic Reasoning for Pulmonary Embolism
Medical reasoning is a form of inquiry that examines the thought processes involved in making medical decisions. When physicians are faced with patients' symptoms or signs, their thought processes follow either direct shortcuts…
- Conditions
- Pulmonary Embolism, Diagnostic Uncertainty, Clinical Reasoning, Evidence Based Medicine
- Trial name
- NCT01752673
- Testing
- Visualized pulmonary embolism computer task model, Didactic review lecture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hemodialysis
Pneumatic Compression Stockings During Hemodialysis
This study aims to determine the effect of pneumatic compression devices (PCDs) on central blood volume in hemodialysis patients.
- Trial name
- NCT01067170
- Testing
- Pneumatic Compression Stockings
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- University of Calgary
Bipolar Disorder
Clinical Trial of a Nutritional Supplement in Adults With Bipolar Disorder
The purpose of the trial was to determine whether a 36-ingredient micronutrient supplement (primarily vitamins and minerals) is beneficial for the treatment of bipolar disorder, when studied under randomized and fully blinded…
- Trial name
- NCT00109577
- Testing
- MCN36 (nutritional supplement)
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Diabetic Peripheral Neuropathy
Safety Study of Intranasal Insulin in Type 1 Diabetes and Diabetic Peripheral Neuropathy
The aim of this study is to evaluate the safety and tolerability of intranasal insulin in people with type 1 diabetes and diabetic peripheral neuropathy and to determine whether intranasal insulin is effective in slowing the…
- Trial name
- IIDPN (NCT01469559)
- Testing
- Novolin Toronto insulin, Normal saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Fluid Therapy, Cardiac Surgical Procedures
Internal Jugular Vein Ultrasound Measures and Fluid Responsiveness in Post-Operative Cardiac Surgical Patients
The goal of this study is to evaluate whether measures of the size of the internal jugular vein have clinical utility in predicting whether patients may benefit from treatment with intravenous fluid.
- Trial name
- NCT00500981
- Testing
- Volume challenge, Ultrasound evaluation of internal jugular vein
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Colonoscopy Preparation
Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy
Proper bowel cleansing prior is an essential requirement for the conduct of colonoscopy. However, due to the nature of cleansing process, the ideal bowel cleansing preparation remains elusive.
- Trial name
- NCT01610856
- Testing
- Polyethylene Glycol
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Colorectal Cancer
Split Dose Polyethylene Glycol (PEG) + Clear Fluids Versus Split Dose PEG + Low-Residue Diet
The objective of the study is to examine the effect of adding a strict low-residue lunch on the day before colonoscopy has on clinical efficacy and patient tolerability of bowel preparation, with patients receiving split-dose…
- Trial name
- BP (NCT01610895)
- Testing
- Split-dose PEG Based Lavage (2L + 2L) with Low-Fibre Lunch Dietary instructions, Split-dose PEG Based Lavage (2L + 2L) with Standard Dietary Instructions
- Where
- Canada
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Bowel Preparation for Colonoscopy
Split Dose Pico-Salax + Bisacodyl vs. PEG Split Dose
The objective of this study is to compare the efficacy, safety and tolerability of two bowel preparations for colonoscopy - split dose Polyethylene Glycol-Based Lavage and Pico-Salax plus Bisacodyl - with a specific emphasis on…
- Trial name
- BP (NCT01415687)
- Testing
- Polyethylene Glycol-Based Lavage, Pico-Salax (Magnesium Citrate) plus Bisacodyl
- Where
- 2 sites in Canada
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Temporal Lobe Epilepsy
A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy
The primary goal is to determine whether hippocampal electrical stimulation (HS) is safe and more effective than simply implanting an electrode in the hippocampus without electrical stimulation (HI), in patients with mesial…
- Trial name
- METTLE (NCT00717431)
- Testing
- Hippocampal Electrical Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Fever
Anti-pyretic Therapy in Critically Ill Adults
The impact of fever and its management in different medical and surgical populations of critically ill patients has not been explained to date.
- Trial name
- NCT01173367
- Testing
- Aggressive Fever Treatment, Permissive Fever Treatment
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Children's Distress During Flu Vaccination
Reducing Children's Distress Towards Flu Vaccinations
Millions of children in North America receive an annual flu vaccination, many of whom are at risk of experiencing severe distress. Children frequently use technologically advanced devices such as computers and cell phones.
- Trial name
- NCT01529021
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Type 1 Diabetes Mellitus
Assessment of an Alternative Model of Follow-up of Children and Adolescents With Type 1 Diabetes
The purpose of the study is to look at the effect of replacing the physician only visit by a transmission of information on the participant's current diabetes management and blood glucose monitoring results followed by a phone…
- Trial name
- NCT00521105
- Testing
- Virtual visit
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University of Calgary
Ventricular Function, Left
Assessment of Cardiac Involvement of Common Cold in High Performing Athletes by Cardiac Magnetic Resonance Imaging (MRI)
Cardiovascular magnetic resonance (CMR) imaging will be used to assess the impact of common colds and physical training in high-performing athletes. Healthy individuals from the general public will serve as a comparison group.
- Trial name
- NCT00739895
- Testing
- Cardiac magnetic Resonance study, Blood testing
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Infarction, Ischemia
CMR in the Assessment of Patient With ACS in the Emergency Room
In this study, we investigate the role of Cardiac Magnetic Resonance Imaging in patients with suspected, but not yet proven, "acute cardiac syndrome ACS".
- Conditions
- Infarction, Ischemia, Magnetic Resonance Imaging
- Trial name
- NCT00564382
- Testing
- Cardiac magnetic Resonance study
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Vascular Diseases, Myocardial Ischemia
Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging
The ability of a new SSFP-based BOLD MRI sequence to assess myocardial oxygenation changes in response to coronary flow changes induced by adenosine and increased CO2-partial pressure will be examined in healthy volunteers and…
- Trial name
- NCT00693758
- Testing
- adenosine, modified end-tidal forcing system, arm cuff occlusion
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Endothelial Function
Endothelial Function Assessed With BOLD-MRI
The purpose of this study is to assess the applicability of a new SSFP-based BOLD sensitive MRI sequence in evaluating endothelial function. Endothelial function will be tested in a setting of reactive hyperemia in the forearm.
- Trial name
- EFBOLD-MRI (NCT00575120)
- Testing
- ischemia reperfusion
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Advanced Glenohumeral Arthritis
Humeral Resurfacing Hemiarthroplasty
The primary objective of this study is to examine quality of life outcomes in patients who have undergone a humeral surface replacement hemiarthroplasty.
- Trial name
- CAP (NCT00477360)
- Testing
- Humeral surface replacement hemiarthroplasty (CAP)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary