Clinical trials: sponsored by University of Chicago
Alzheimer s Disease, Dementia
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and…
- Conditions
- Alzheimer s Disease, Dementia, Caregiver, Loneliness
- Trial name
- CRxDpeer (NCT07346183)
- Testing
- CommunityRx-Dpeer
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Ovarian Cancer, Advanced Malignant Solid Tumor
A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.
This phase I/IIA trial studies the side effects and best dose of gene-modified T cells when given with or without decitabine, and to see how well they work in treating patients with malignancies expressing cancer-testis antigens.
- Trial name
- NCT07389239
- Testing
- Decitabine, Cyclophosphamide Conditioning, NY-ESO-1 TCR/ dnTGFβRII
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
GERD
PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients
This is a prospective, within-subject controlled study involving simultaneous dual placement of wireless Bravo pH probes in each participant.
- Trial name
- PROPER-GERD (NCT07716592)
- Testing
- Bravo pH monitoring sessions
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
PCOS, PCOS (Polycystic Ovary Syndrome)
PMOS in OSA Pilot Study
The goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
- Conditions
- PCOS, PCOS (Polycystic Ovary Syndrome), OSA, OSA - Obstructive Sleep Apnea
- Trial name
- NCT07871149
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Injection Fear, Injection Pain Prevention
Does Ethyl Chloride Spray Work?
A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal…
- Conditions
- Injection Fear, Injection Pain Prevention, Injection Complication
- Trial name
- NCT06651788
- Testing
- Ethyl Chloride, Cold Saline Spray
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- University of Chicago
HIV, Pre-exposure Prophylaxis
Case Management Dyad
The overall goal of this study is to test whether dyadic and focused case management coupled with contingency management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates…
- Conditions
- HIV, Pre-exposure Prophylaxis, Case Management, Contingency Management
- Trial name
- CM2 (NCT06162897)
- Testing
- Dyadic Case Management
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago
Weight Loss
A Novel Intervention for Weight Loss in Young Adults
Obesity and cardiometabolic risks are significant public health issues, with about two-thirds of U.S. adults overweight or obese.
- Trial name
- NCT06230744
- Testing
- Lifestyle, Lifestyle II
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV
Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men
The goal of this observational study is to learn about the pilot test of the employment program among young men living with HIV or part of a community highly impacted by HIV.
- Trial name
- NCT06894199
- Testing
- The Work Shop
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV Treatment
Building Rapid Inpatient Delivery of ART to Generate Engagement in HIV Care
The study team will pilot rapid antiretroviral therapy (ART) initiation as part of routine inpatient care at the University of Chicago Medicine (UCM), comparing outcomes over a 12-month implementation period.
- Trial name
- BRIDGE (NCT07847567)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Breast Cancer
Study to Understand Relationship Between Gut Health and Toxicities of Hormonal Breast Cancer Treatment
This study will be conducted in 2 sequential parts. The first part will be a prospective, observational study. This will be followed by a small interventional, pilot study involving use of fiber supplement (chia seeds).
- Trial name
- GEMMA (NCT07553234)
- Testing
- Stool Sampling, Chia Seeds
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Immune-related Adverse Event
Pharmacokinetic Study of Therapeutic Plasma Exchange
The purpose of this study is to characterize the pharmacokinetics of one or more ICIs during and after TPE/PLEX in patients with severe irAEs.
- Trial name
- NCT07756242
- Testing
- Spectra Optia Apheresis System
- Where
- United States
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder, OCD
A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder
The primary aim of the present study is to examine the efficacy and safety of tolcapone in adults with moderate to severe OCD.
- Trial name
- NCT05624528
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Chicago
Multiple Myeloma, Relapse Multiple Myeloma
Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma
Doctors leading this study hope to learn if the combination of belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone is effective and safe when given to people who have multiple myeloma that has gotten worse and is…
- Trial name
- NCT05789303
- Testing
- Belantamab mafodotin, Carfilzomib, Pomalidomide
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Chicago
Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Tegoprubart (AT-1501) is a monoclonal antibody. Antibodies are Y-shaped proteins that are produced naturally by the subject's immune system to attack and fight foreign substances that cause illness.
- Trial name
- Tegoprubart (NCT06305286)
- Testing
- Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Colorectal Cancer
Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent.
- Trial name
- DIET (NCT06349590)
- Testing
- High-fiber/low-fat meals
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Frailty
Voice-Activated Technology to Improve Mobility in Multimorbid, Frail, Homebound Older Adults (EngAGE)
The purpose of this study is to test the efficacy of EngAGE (an interactive, voice-activated app) vs usual care on improving older adult physical and social function.
- Trial name
- EngAGE (NCT05337514)
- Testing
- Enhanced Engagement, Standard Engagement
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Chicago
Sickle Cell Disease, Acute Chest Syndrome
Tocilizumab for Acute Chest Syndrome
The investigators are evaluating the role of a low dose of tocilizumab in treating acute chest syndrome in patients with sickle cell disease.
- Trial name
- NCT05640271
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Brain Metastases
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
This is a randomized study to determine if not treating planning target volume (PTV) margins during radiation therapy worsens progression free survival rates in patients with brain metastases.
- Trial name
- NCT02747303
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Chicago