Clinical trials: sponsored by University of Chicago
Chronic Pelvic Pain
Empowered Relief for Chronic Pelvic Pain
Primary Aim To determine if the addition of empowered relief therapy to standard treatment is superior to standard treatment alone in patients with chronic pelvic pain as measured by pain interference in patients with chronic…
- Trial name
- ER_for_CPP (NCT07812857)
- Testing
- Empowered Relief (ER) Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Endometrial Cancer
Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer
This study will investigate if a shorter treatment course (known as "hypofractionation") for pelvic radiation is safe for women with endometrial cancer.
- Trial name
- NCT04683653
- Testing
- Hypofractionated Radiation, Clinical Follow-Up and Assessments
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Gastric Cancer, Peritoneal Carcinomatosis
Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer
To assess if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone
- Trial name
- NCT04107077
- Testing
- Cisplatin, Mitomycin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Chicago
Feeding Tube, Children With Medical Complexity
Let's E.A.T.! (Eating With Assistive Technology): An Intervention to Support Children With Feeding Tubes and Tracheostomies
The overall objective of this proposal is to test an interdisciplinary intervention to support the transition to oral feeding for children with feeding tubes and tracheostomies.
- Conditions
- Feeding Tube, Children With Medical Complexity, Tracheostomy, Feeding Disorder, Infancy or Early Childhood
- Trial name
- NCT06525818
- Testing
- Tube weaning therapy intervention, Feeding Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Kidney Stones
SGLT2i in Kidney Stones
This study is looking at whether empagliflozin, a medication typically used for diabetes and heart conditions, may affect factors that contribute to kidney stone formation.
- Trial name
- NCT07055282
- Testing
- Empagliflozin (Jardiance®)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Breast Cancer
A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.
- Trial name
- CAPS (NCT03729115)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Myeloproliferative Neoplasms
Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation
The purpose of this research is to gather information on the safety and effectiveness determining maximum tolerated dose (MTD) of ruxolitinib in combination with ivosidenib in IDH1-mutated advanced-phase Ph-negative MPNs while…
- Trial name
- MPN (NCT06291987)
- Testing
- Ivosidenib, Ruxolitinib
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Crohn's Disease (CD), Ulcerative Colitis (UC)
Virtual Group Therapy for IBD Patients With Anxiety and Depression
This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety.
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety
- Trial name
- NCT07796568
- Testing
- Group Psychotherapy Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Prostate Cancer, Prostate Adenocarcinoma
A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer
Researchers conducting this study hope to learn about the safety and effectiveness of combining two study drugs, relacorilant and enzalutamide, plus androgen deprivation therapy (ADT), also known as hormone therapy.
- Trial name
- NCT05726292
- Testing
- Relacorilant, Enzalutamide, Androgen Deprivation Therapy
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Influenza, COVID-19
Dime La VerDAD: Verify, Debunk, and Disseminate
Dime la Verdad (Tell me the truth) will evaluate the use of storytelling by community health workers as a communication strategy to disseminate reliable health information on social media and encourage informed decision-making in…
- Conditions
- Influenza, COVID-19, Communication Research, Health Behavior
- Trial name
- NCT06417762
- Testing
- Science Communication Curriculum Cohort 1, Science communication curriculum Cohort 2, Science communication curriculum Cohort 3
- Where
- 4 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Femoral Shaft Fracture, Tibial Shaft Fractures
Rehabilitation After Lower Extremity Nailing Trial
The goal of this clinical trial is to learn if outpatient physical therapy (PT) results in differing functional outcomes compared to a self-guided home exercise program (HEP) in tibial or femoral nail patients.
- Trial name
- ReLENT (NCT07783568)
- Testing
- Formal Physical Therapy (PT), Home Exercise Program (HEP)
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Diabete Type 1, Chronic Kidney Disease
Breakthrough - T1DM and Chronic Kidney Disease
Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: An…
- Trial name
- NCT07592000
- Testing
- Tegoprubart, Islet Cell Transplant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Surgery, Upper Extremity
Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery
The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block.
- Trial name
- NCT07773155
- Testing
- Toradol, Oxycodone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Adverse Radiation Effects, Radiation Necrosis
Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery
This prospective observational study will investigate the relationship between the gut microbiome and adverse effects following stereotactic radiosurgery (SRS).
- Trial name
- MICRO-ARE-SRS (NCT07767981)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Surgery
Brain Function Monitoring During Surgery
The purpose of this research is to gather information on the effectiveness of the Sedline Brain Function Monitor, and its use in this study to determine whether monitoring the brain activity during anesthesia will improve…
- Trial name
- NCT06619730
- Testing
- Sedline Brain Function Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Cancer
Engaging and Activating Cancer Survivors in Genetic Services Study
To address the gap in access to genetic services, this study will evaluate the effectiveness of an adapted model of remote delivery of genetic services to increase the uptake of recommended genetic assessment and testing in…
- Trial name
- ENGAGE (NCT04455698)
- Testing
- Remote Telegenetic Counseling by Phone, Remote Telegenetic Counseling by Videoconferencing, Usual Care Arm
- Where
- 3 sites in United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Chicago
to Determine Whether Patient Satisfaction With Postoperative Telehealth Follow-up is Non-inferior to In-person Clinic Visits
Outpatient Visits Versus Telehealth for Postoperative Care After Minimally Invasive Gynecologic Surgery
Telehealth, or telemedicine, utilizes technology to deliver clinical care remotely, either in real time or asynchronously, between clinician and patient.
- Trial name
- Telehealth RCT (NCT07420114)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Hypertension
Mobile Health Management of Hypertension
The investigators will pilot test a hypertension self-management intervention for feasibility and acceptability. The investigators will enroll adults (age ≥18) with uncontrolled hypertension, identified from the electronic health…
- Trial name
- NCT05856955
- Testing
- mHealth Coaching Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Health Related Social Needs (HRSN)
CommunityRx-Dementia
Caregivers of home-dwelling people with Alzheimer's Disease and related dementias (ADRD) are one of the most rapidly growing populations in the United States.
- Trial name
- CRx-D (NCT04146545)
- Testing
- Community Rx-Dementia "CRxD" Caregiver Resources
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Chicago