Clinical trials: sponsored by University of Cincinnati
Bipolar I Disorder
Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Disorder
The purpose of the research is to study brain structure, function and chemistry of patients with bipolar disorder who are receiving lithium, an FDA-approved treatment for bipolar mania, in order to better understand who benefits…
- Trial name
- LAMBS/LADS (NCT00608075)
- Testing
- lithium
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hemorrhage
Non-Invasive Hemoglobin Monitoring in Patients With Hemorrhage
This study will evaluate the accuracy of two rapid methods of measuring hemoglobin in patients with suspected hemorrhage. These methods will be compared with standard laboratory measurements.
- Trial name
- NCT01709786
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Cincinnati
Depression, Suicidal Ideation
Emergency Ketamine Treatment of Suicidal Ideation
The objective of the current program of research will be to test whether intranasal ketamine treatment is more effective than placebo in reducing suicidal ideation in suicidal patients presenting for acute treatment in emergency…
- Conditions
- Depression, Suicidal Ideation, Suicidal Impulses
- Trial name
- NCT02183272
- Testing
- Intranasal Ketamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Kidney Transplant Recipients
Evaluate Effects and Safety of Pre-load Myfortic® in Transplant Patients
This study is specifically designed to determine whether the initiation of Myfortic 2 weeks prior to transplantation will enhance the therapeutic efficacy of Simulect induction therapy in low to moderate risk patients.
- Trial name
- NCT01336296
- Testing
- mycophenolic acid
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Cincinnati
Morbid Obesity, Cardiovascular Disease
Omega-3 Fatty Acid Status in Morbid Obesity Before and After Surgical Treatment
The purpose of this study is to determine the concentration of omega-3 fatty acids in plasma, blood and abdominal fat before and after bariatric surgery to provide guidance for future studies.
- Conditions
- Morbid Obesity, Cardiovascular Disease, Fatty Acid Levels
- Trial name
- NCT00558532
- Testing
- Bariatric Surgery
- Where
- United States
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Age-related Memory Disorders, Mood Disorders
Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline
The aim of this study is to determine the efficacy of 6 months' dietary supplementation with omega-3 fatty acids and whole freeze dried blueberry powder in improving cognition in older adults.
- Trial name
- NCT01746303
- Testing
- Omega-3 fatty acid, Blueberry powder
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Mania, Bipolar Disorder
Multimodal Neuroimaging of Treatment Effects in Adolescent Mania
Specific Aim 1: To determine the effects of treatment with quetiapine or lithium on brain activation in adolescents. The investigators will use functional magnetic resonance imaging (fMRI) to examine brain activation during an…
- Trial name
- NCT00893581
- Testing
- Healthy Controls
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety, Bipolar Disorder
Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
Children who have parents with bipolar disorder are at risk for developing anxiety disorders.
- Trial name
- Mindfulness (NCT02090595)
- Testing
- MBCT-C, Waitlist Control
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Mood Disorder
Mindfulness in Mood Dysregulated Youth
Mindfulness group therapy can help children with mood irregularities and family history of bipolar disorder.
- Conditions
- Bipolar Disorder, Mood Disorder, Emotional Disturbance
- Trial name
- NCT02120937
- Testing
- MBCT-C Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
End Stage Renal Disease (ESRD)
Study of Myfortic in Combination With Tacrolimus and Thymoglobulin in Early Corticosteroid Withdrawal
To determine the safety and efficacy of a new formulation of Myfortic in combination with tacrolimus and thymoglobulin.
- Trial name
- NCT00374803
- Testing
- Mycophenolic Acid (Myfortic)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Cincinnati
Breast Cancer
Positron Emission Mammography (PEM) Biopsy Accessory for the Diagnosis of Breast Cancer
The purpose of this research study is to evaluate how well the Stereo Navigator Biopsy Accessory for the PEM Flex solo II PET Scanner works for performing breast biopsy on suspicious lesions.
- Trial name
- NCT00981812
- Testing
- PEM Breast Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
HLA Sensitization
Desensitization in Kidney Transplantation
To determine if deletional strategies will provide effective desensitization.
- Trial name
- NCT00908583
- Testing
- plasmapheresis, Bortezomib, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Cincinnati
Kidney Transplant Recipients, Liver Transplant Recipients
Pharmacokinetic Studies of Tacrolimus in Transplant Patients
The study is designed to compare the steady-state pharmacokinetics of Prograf (Brand) and the two most disparate generic formulations (Generic Hi and Generic Lo) in a fully replicated, 3-way cross-over study in stable kidney…
- Trial name
- PK (NCT01889758)
- Testing
- Prograf, Tacrolimus
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Cincinnati
Graft Rejection
Randomized Trial for Mixed Acute Rejection
This study is being conducted to determine how safe and effective using an immune cell (b cell) depleting therapy and/or Thymoglobulin is in patients with a kidney transplant who are experiencing certain types of rejection.
- Trial name
- NCT00771875
- Testing
- Rabbit Antithymocyte Globulin (RATG), Rituximab, Bortezomib
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Kidney Transplantation
Randomized Trial of Induction Therapies in High Immunological Risk Kidney Transplant Recipients
The purpose of this research study is to find out the effects of adding B lymphocyte modulating agents in patients at risk for rejection receiving an anti-rejection (immunosuppressive) regimen of Thymoglobulin® induction with…
- Trial name
- NCT00782821
- Testing
- Rabbit Antithymocyte Globulin, Velcade, Rituxan
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Renal Transplant Rejection, Transplants and Implants
Prospective Pilot Study of Pre-Transplant Thymoglobulin Administration in Living Donor Renal Transplant Recipients
To determine how safe and effective giving Thymoglobulin before transplantation to patients who are going to be receiving kidney transplants.
- Trial name
- NCT00771745
- Testing
- Thymoglobulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Cincinnati
Stimulant Dependence
An Eval of Neurocognitive Function, Oxidative Damage, and Their Association With Outcomes in METH and Cocaine Abusers.
The purpose of this study is to determine whether performance on neurocognitive measures predicts treatment outcomes in individuals with substance abuse disorders.
- Trial name
- NCT00628927
- Where
- 6 sites in United States
- Volunteers
- 217 people
- Sponsor
- University of Cincinnati
Liver Transplantation
Single Center Pilot Study of Corticosteroid Discontinuation in Liver Transplant Recipients
To determine the safety and efficacy of early corticosteroid discontinuation in liver transplant recipients more than 90 days post transplant, utilizing a combination of two drugs (tacrolimus and mycophenolate mofetil) for…
- Trial name
- NCT00374231
- Testing
- tacrolimus, mycophenolate mofetil, Prednisone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Trauma
Pre-hospital Hypoxemia in Trauma Patients
The intent of this study is to describe the proportion of trauma patients requiring oxygen before hospital arrival, the amount of oxygen they require, and whether or not the oxygen is beneficial to outcomes.
- Trial name
- NCT01074983
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Cincinnati