Clinical trials: sponsored by University of Cincinnati
Sarcoidosis
Riociguat for Sarcoidosis Associated Pulmonary Hypertension
Double blind placebo controlled trial of riociguat for sarcoidosis associated pulmonary hypertension
- Trial name
- RioSAPH (NCT02625558)
- Testing
- Riociguat
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Sarcoidosis, Pulmonary Sarcoidosis
Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS)
An randomized trial of two maintenance doses of Acthar Gel for patients with chronic pulmonary sarcoidosis. Patients will be observed for 24 weeks of treatment.
- Trial name
- ACPS (NCT02188017)
- Testing
- Acthar gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Sarcoidosis
Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS)
Pulmonary sarcoidosis patients with fibrosis often develop recurrent episodes of bronchitis. These can lead to worsening of disease for both the short and long term.
- Trial name
- REFS (NCT01830959)
- Testing
- Roflumilast
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Sarcoidosis, Pulmonary Hypertension
Registry of Sarcoidosis Associated Pulmonary Hypertension (RESAPH)
Registry to follow patients with sarcoidosis associated pulmonary hypertension
- Trial name
- RESAPH (NCT01467791)
- Testing
- Observation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Cincinnati
Bipolar Disorder
Functional and Neurochemical Brain Changes in First-episode Bipolar Mania
The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium.
- Trial name
- NCT00609193
- Testing
- lithium, quetiapine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Cincinnati
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Hepatitis C
Evaluating the Role of Immune Responses in the Emergence of Protease Inhibitor Mutations
The major goal of this project is to identify the role of the immune responses in the emergence of protease inhibitor mutants during therapy.
- Trial name
- NCT01517529
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Subarachnoid Hemorrhage
Monitoring of Delayed Ischemia After Subarachnoid Hemorrhage
The goal in this research is to develop better ways to detect and treat the damage caused by bleeding in the brain.
- Trial name
- MODISH (NCT01406457)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Cincinnati
Epilepsy
Equivalence Among Antiepileptic Drug Generic and Brand Products in People With Epilepsy: Chronic-Dose 4-Period Replicate Design
The United States Food and Drug Administration (FDA) has specific rules generic drug companies must follow to get a generic copy of a seizure medication approved.
- Trial name
- Chronic Dose (NCT01713777)
- Testing
- Lamotrigine Generic "A", Lamotrigine generic "B"
- Where
- 8 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Cincinnati
HIV, Hepatitis C, Chronic
The Study of Gut Associated Lymphocytes in HIV and HCV/HIV Co-infected Patients
The purpose of this research study is to explore what role immune cells within the gut (the sigmoid colon) have locally and on the immune system of patients infected with HCV, HIV or HCV/ HIV co-infection.
- Conditions
- HIV, Hepatitis C, Chronic, HCV Coinfection
- Trial name
- NCT01335230
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Systolic Heart Failure
Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been used safely in humans for decades for this and other indications.
- Trial name
- ReProsperHF (NCT01814319)
- Testing
- Probenecid 1 gr oral twice daily
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Diabetes, Gestational
Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM)
The purpose of this research study is to compare 3 methods of measuring blood glucose (blood sugar) levels to see if the finger-stick method or the continuous glucose monitoring system is better than or as good as the 3 hour…
- Trial name
- NCT01074489
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Cincinnati
Fatigue Syndrome, Chronic
Double Blind Trial of Duloxetine in Chronic Fatigue Syndrome
The purpose of this study is to determine the safety and efficacy of duloxetine compared with placebo for reducing fatigue in patients diagnosed with Chronic Fatigue Syndrome (CFS).
- Trial name
- CFS (NCT00375973)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Attention Deficit Disorder With Hyperactivity
Cortical Excitability: Phenotype and Biomarker in Attention-deficit, Hyperactivity Disorder (ADHD) Therapy
The purpose of this study is to find out if children with attention-deficit, hyperactivity disorder (ADHD) have a difference in how their brain cells "fire" or react.
- Trial name
- NCT01330693
- Testing
- Atomoxetine, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
Intracranial Aneurysm, Subarachnoid Hemorrhage
Familial Intracranial Aneurysm Study II
The purposes of this study are to identify possible genes that may increase the risk of aneurysm development in the brain, and to determine the effect of environmental factors such as cigarette smoking and high blood pressure on…
- Trial name
- NCT00071565
- Where
- 16 sites in United States
- Volunteers
- 5,875 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Thrombosis of Left Atrial Appendage
Left Atrial Volume Index and Left Atrial Appendage Flow Velocities
After obtaining a consent, bed side cardiac ultrasonography will be performed for cases undergoing transesophageal echocardiography to evaluate the correlation between left atrium volume and left atrial appendage flow velocity…
- Trial name
- NCT02500745
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Cincinnati
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Alzheimer's Disease, Dementia
Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
The primary aim is to determine whether Divalproex ER or one of the atypical antipsychotics is more effective improving dementia related behavioral symptoms in patients with dementia, and evaluate the impact of such improvements…
- Conditions
- Alzheimer's Disease, Dementia, Behavioral Symptoms
- Trial name
- NCT00375557
- Testing
- Divalproex ER, Quetiapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Sarcoidosis, Fatigue
Use of Armodafinil for Fatigue in Sarcoidosis
To determine the effect of Armodafinil (Nuvigil) on fatigue and sleep in sarcoidosis.
- Conditions
- Sarcoidosis, Fatigue, Sleepiness
- Trial name
- NCT00555347
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
End Stage Renal Disease
Pharmacokinetics of Immunosuppressants in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate how quickly and to what extent different immunosuppressants are absorbed into the blood (this is called pharmacokinetics) in renal transplant candidates who have undergone a laparoscopic…
- Trial name
- NCT02221583
- Testing
- Astagraf XL, Prograf, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Cincinnati