Clinical trials: sponsored by University of Cincinnati
Parkinson's Disease, Gait Impairment
Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
The purpose of this research study is to examine whether Methylphenidate (MPD) can result in improvement of gait (walking) in a population of Parkinson's Disease (PD) patients whose main disability is freezing of gait.
- Trial name
- NCT00526630
- Testing
- Methylphenidate (MPD)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Cincinnati
Infantile Refsum's Disease, Zellweger Syndrome
Study of Bile Acids in Patients With Peroxisomal Disorders
OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid, chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders involving impaired primary bile acid synthesis. II.
- Conditions
- Infantile Refsum's Disease, Zellweger Syndrome, Bifunctional Enzyme Deficiency, Adrenoleukodystrophy
- Trial name
- NCT00004442
- Testing
- chenodeoxycholic acid, cholic acid, ursodiol
- Volunteers
- 25 people
- Sponsor
- University of Cincinnati
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Depression, Bipolar
Functional and Neurochemical Brain Changes Bipolar Depression
The purpose of the research is to study brain structure, function and chemistry of patients with bipolar disorder who are receiving quetiapine or lithium, in order to better understand who benefits from treatment and why they…
- Trial name
- NCT00608296
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Mania
Peroxisomal Defects and Familial Risk for Bipolar Disorder
The purpose of this study is to screen for peroxisome defects in child and adolescent offspring of Bipolar Disorder I (BD-I) parents at different stages of risk for transitioning to mania and following the onset of mania.
- Trial name
- NCT01237379
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Renal Transplant
Pilot Study for HLA Identical Living Donor Renal Transplant Recipients
The purpose of this study is to evaluate the safety and effectiveness of a steroid-free and calcineurin-inhibitor free treatment regimen for patients who are receiving a kidney transplant from a living donor that is HLA-identical…
- Trial name
- NCT00352092
- Testing
- calcineurin inhibitor, sirolimus, mycophenolate mofetil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Hypoxemia, Hypobaric Hypoxemia
Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects
This study will compare the ability of pulsed-dose oxygen from a concentrator to reverse altitude-induced hypoxemia compared to compressed gas from a standard oxygen cylinder.
- Trial name
- NCT01477450
- Testing
- Pulse-dose oxygen, Cylinder oxygen delivery
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hepatitis C, HIV Infections
Effects of Anti-HIV Drugs on the Hepatitis C Virus (HCV) in Adults Infected With Both HCV and HIV
The purpose of this study is to measure the effects of anti-HIV drugs on hepatitis C virus (HCV) viral load in people infected with both HCV and HIV.
- Trial name
- ART and HCV (NCT00545558)
- Testing
- Efavirenz, Emtricitabine/Tenofovir disoproxil fumarate
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Cellulitis, Skin Infections
Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infections
This is a prospective, randomized clinical trial comparing daptomycin to vancomycin in the Emergency Department (ED) treatment of complicated skin and skin structure infection in the Rapid Diagnosis and Treatment Center (RDTC).
- Trial name
- NCT01549613
- Testing
- Daptomycin, Vancomycin
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Ischemic Stroke, Stroke
Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke
The primary goal of this trial is to determine if individuals with acute ischemic stroke treated with a medium dose of IV rt-PA plus IV eptifibatide started within 3 hours of symptom onset are more likely to have a better outcome…
- Conditions
- Ischemic Stroke, Stroke, Brain Infarction
- Trial name
- CLEAR-ER (NCT00894803)
- Testing
- Eptifibatide, rt-PA
- Where
- 20 sites in United States
- Volunteers
- 126 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati
Acute Myocardial Infarction
Minimizing Reperfusion Injury in Patients With Acute Myocardial Infarction
The size of a heart attack will be decreased by the use of timed balloon inflations to open the blocked blood vessel.
- Trial name
- PCinAMI (NCT00846378)
- Testing
- Post conditioning, Usual Care for STEMI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Nicotine Dependence, Bipolar Disorder
Targeted Intervention for Bipolar Smokers
The purpose of this research is to develop and test a new type of smoking cessation counseling for individuals with bipolar disorder.
- Trial name
- NCT01550029
- Testing
- Counseling/Healthy Lifestyle, Counseling/Managing Mood
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Dyspareunia
Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain
The purpose of this study is to evaluate which treatment option for pelvic floor pain allows for improved sexual function.
- Trial name
- NCT02022722
- Testing
- Trigger Point Injections Triamcinolone Acetonide, Bupivacaine Hydrochloride, Pelvic Rehabilitation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Cincinnati
Sarcoidosis
Rituximab for Pulmonary Sarcoidosis
Sarcoidosis is a inflammatory disease affecting many parts of the body, especially the lungs. While most patients do well, there is a group of patients who require continuous doses of prednisone or other drugs.
- Trial name
- RIPS (NCT00855205)
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Bipolar I Disorder
A Double-Blind Randomized Placebo Controlled Study of Quetiapine for the Treatment of Depression in Adolescents With Bipolar Disorder
In this study, quetiapine is being tested for the possible treatment of bipolar I disorder with an acute depressive episode in children and adolescents.
- Trial name
- NCT00232414
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
A Trial of Two Daclizumab Dosing Strategies vs. No Induction Treatment With Tacrolimus, Mycophenolate Mofetil , & Steroids for the Prevention of Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
The purpose of the study is to determine the safety and efficacy of two dosing regimens of daclizumab in simultaneous kidney/pancreas transplant recipients.
- Trial name
- NCT00363116
- Testing
- Daclizumab
- Where
- 24 sites in United States, Canada
- Volunteers
- 298 people
- Sponsor
- University of Cincinnati
Pneumonia
Clinician Ability to Predict the Presence of Nosocomial Pneumonia Based on Bronchoscopic Findings
This study aims to determine whether interpretations of bronchoscopic results enable physicians to successfully predict the presence of pneumonia in traumatically injured patients.
- Trial name
- NCT01904305
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Bipolar Disorder
An Open-Label Trial of Aripiprazole in Children and Adolescents With Bipolar Disorder
This is an investigator-initiated study whose primary aim is to determine the effectiveness of aripiprazole (Abilify®) in helping persons with symptoms of mania whose current medications do not completely control those symptoms.
- Trial name
- NCT00221416
- Testing
- Aripiprazole
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati