Clinical trials: sponsored by University of Cincinnati
Occupational Health, Sleep
Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue
The U.S. registered nurse (RN) workforce is the largest in the Healthcare and Social Assistance Sector and is at high risk for injuries and errors due to poor sleep and fatigue.
- Conditions
- Occupational Health, Sleep, Fatigue, Nurse
- Trial name
- RN-SLEEP (NCT06105307)
- Testing
- RN-SLEEP, Healthy Habit - Educational Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cervical Cancer, Radiation Therapy Complication
Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies
This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation…
- Conditions
- Cervical Cancer, Radiation Therapy Complication, Pelvic Floor Disorders
- Trial name
- NCT07447895
- Testing
- Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Cincinnati
Mild Depression
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment…
- Trial name
- NAC+MIND (NCT07464886)
- Testing
- N-acetylcysteine, Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Cincinnati
Family Caregivers, Stroke
Telehealth Assessment and Skill-Building Intervention for Stroke Caregivers (TASK III)
Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers.
- Trial name
- NCT05304078
- Testing
- Telehealth Assessment and Skill-Building Kit (TASK III) Group, Information Support and Referral (ISR) Group
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hypoglycemia, Type 1 Diabetes
Effect of C-peptide on Hypoglycemic Counterregulation
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization.
- Trial name
- NCT06470295
- Testing
- Saline, C-peptide
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Radiation Injuries
Oral 5 Strain Probiotic for GI Toxicity Mitigation During Pelvic Radiation
This research is to determine if an oral probiotic, Pendulum Glucose Control (PGC), can be safely given to patients during pelvic radiation therapy (RT).
- Trial name
- NCT07231588
- Testing
- Pendulum Glucose Control (PGC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Brain Cancer
Measuring the Feasibility and Effect of a Virtual Reality Cognitive Training Intervention for Brain Cancer Survivors.
The study is focused on assessing the feasibility and effect of a virtual reality training intervention for improving the survivorship journey of brain cancer survivors, post-treatment.
- Trial name
- NCT07313709
- Testing
- Virtual Reality System, Word Search Puzzles
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
Spreading Depolarizations in Traumatic Brain Injury
This research aims to extend the application of spreading depolarization monitoring to non-surgical TBI patients, using intraparenchymal electrode arrays and scalp electroencephalography to detect depolarizations and develop less…
- Trial name
- NCT03379220
- Where
- 7 sites in United States
- Volunteers
- 147 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies…
- Trial name
- INDICT (NCT05337618)
- Testing
- Full-band Electrocorticography, Treatment Algorithm
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Cincinnati
Anal Cancer
REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation
To determine the efficacy of reduced elective nodal radiation in anal cancer patients undergoing chemoradiation in reducing toxicity compared to standard nodal irradiation.
- Trial name
- REDEL (NCT05902533)
- Testing
- Radiation (reduced elective nodal dose (30.6 Gy), Capecitabine, Mitomycin c
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Cincinnati
Mastectomy; Lymphedema, Breast Cancer
Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks
The purpose this research is to compare two different standards of care for pain management and two different standards of care for local numbing medicine for breast cancer patients who will have a total mastectomy.
- Trial name
- NCT06574022
- Testing
- Bupivacain, Exparel, Intraoperative Pecs II block (IOB) & superior AT (EX or BP)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Cincinnati
Human Papillomavirus Viruses, Papillomavirus Vaccines
Let's K-Talk - HPV Study for Ethnic Koreans
The goal of this clinical trial is to test the feasibility, acceptability, and preliminary efficacy of a storytelling video-based intervention using AI chatbot technology (K-Talk) to promote HPV vaccination behavior among Korean…
- Trial name
- NCT05884697
- Testing
- K-Talk Intervention (Storytelling and K-Bot), Storytelling Intervention, K-Bot Intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Ischemic Stroke, Acute, Large Vessel Occlusion
Image Detection of Impaired Microcirculatory Reperfusion
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain.
- Trial name
- ID IMR (NCT07099599)
- Testing
- CT Perfusion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Transgender Women, Voice Alteration
Gender-affirming Voice Training With Visual Feedback
The goal of this clinical trial is to learn if prototype software can be used to train vocal pitch and resonance in trans women.
- Trial name
- NCT07017595
- Testing
- Visual-acoustic biofeedback: experimental
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Cincinnati
Premature Infant Disease, Family Research
PREEMIE PROGRESS: A Family Management Program for Parents of Preterm Infants
The purpose of this study is to refine and pilot test a mobile health (mHealth), video-based family management program for parents of preterm infants hospitalized in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Premature Infant Disease, Family Research, Parent-Child Relations, Self Efficacy
- Trial name
- NCT04638127
- Testing
- PREEMIE PROGRESS, Attention Control
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hypobaric Hypoxemia
Enhancing Operability in a Hypobaric Hypoxic Environment With a Small Oxygen Storage System
This is a study to validate the efficacy of using a small portable oxygen source to mitigate altitude-induced hypoxia.
- Trial name
- NCT03365128
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Metastatic Bone Tumor
Palliative UNConventional Hypofractionation Trial for Metastatic Bone Disease
This is a randomized Phase III study evaluating the efficacy of hypofractionated and dose-escalated palliative radiation therapy in metastatic bone disease (MBD).
- Trial name
- 1-2 PUNCH (NCT05115331)
- Testing
- Experimental Radiation Dose, Conventional Radiation Dose
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Cincinnati
Cancer of the Prostate
Proton Boost in Prostate Cancer
This study uses photon radiation with a proton boost to treat prostate cancer. The purpose of this study is to determine if proton therapy as a boost following photon intensity modulated radiation therapy (IMRT) produces…
- Trial name
- NCT03564275
- Testing
- Proton Boost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Hypoxemia, Hyperoxia
Oximeters and Skin Pigment: Impact of Skin Pigmentation on Accuracy of Pulse Oximetry
Finger pulse oximetry SpO2 is widely used to estimate arterial oxygen saturation SaO2. Current Spo2 targets do not take into consideration the many variables that affect that correlation in particular skin pigmentation.
- Conditions
- Hypoxemia, Hyperoxia, Pigment Skin
- Trial name
- NCT05690269
- Testing
- SpO2 and SaO2 comparison
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of Cincinnati
Dysphagia, Oral Phase, Stroke, Ischemic
Lingual Endurance Exercise in Treating Post-Stroke Dysphagia
Aim 1: Determine feasibility of lingual endurance training for individuals with persistent dysphagia after ischemic stroke. Primary outcome measures: % patient adherence (# of attempted repetitions/# prescribed repetitions) and %…
- Trial name
- NCT05523973
- Testing
- Lingual Endurance Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati