Clinical trials: sponsored by University of Cincinnati
Complication of Transplant
Conversion From Brand to Generic Tacrolimus in High Risk Transplant Recipients
The prospective study will compare the relative bioavailability at steady-state pharmacokinetics of 6 tacrolimus formulations in a prospective, 6-way cross-over study including CYP3A5 expressors (n=30) and non-expressor (n=30)…
- Trial name
- NCT02014103
- Testing
- Prograf, Tacrolimus, Sandoz, Tacrolimus, Reddy Laboratory
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Cincinnati
Ischemic Stroke, TIA
A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites
Our primary goal is to study temporal trends in the incidence rate, causes, treatment, and outcome of stroke among a large biracial metropolitan population of 1,349,351, of whom 215,611 (15%) are black (2000 Census).
- Conditions
- Ischemic Stroke, TIA, Hemorrhage
- Trial name
- GCNKSS (NCT00642213)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Cincinnati
Pre-hospital Ventilation
Ability of Caregivers to Provide Ventilation With the SAVe Resuscitator in a Model
This study will compare three methods of delivering mechanical ventilation using a test lung. Ventilation will be delivered using (1) a mask held in place by a caregiver, (2) a mask strapped to the model using a securing device…
- Trial name
- NCT01477710
- Testing
- Hold mask, Strap Mask, Airway
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stroke, Chronic Stroke
Optimizing Training in Severe Post-Stroke Walking Impairment
Difficulty walking is common after a stroke. Although physical rehabilitation helps a little with the improvement of walking ability, recovery is usually incomplete.
- Conditions
- Stroke, Chronic Stroke, Walking, Difficulty, Gait, Hemiplegic
- Trial name
- BLT2b (NCT04721860)
- Testing
- Backward Locomotion Treadmill Training (BLTT), Forward Locomotion Treadmill Training (FLTT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Hypoglycemia, Type1diabetes
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT05973799
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Liver Tumor
Treat-and-resect Study of Echo Decorrelation Imaging-controlled Radiofrequency Ablation in Liver Tumors
This study will comprise the first pilot clinical trial of 3D, ultrasound-based thermal ablation control using echo decorrelation imaging, directly testing the capability of this approach to ensure reliable tumor treatment.
- Trial name
- NCT05211388
- Testing
- RFA controlled using echo decorrelation imaging, RFA controlled using standard manufacturer-specified algorithms
- Where
- United States
- Sponsor
- University of Cincinnati
Anxious Depression, Depression
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
- Trial name
- DOTS-AD (NCT04245748)
- Testing
- Escitalopram, Duloxetine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Cincinnati
Anxiety
Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
This double-blind, 12-week study will consist include132 anxious youth who are randomized (1:1) to standard or pharmacogenetically-guided escitalopram dosing.
- Trial name
- PrEcISE (NCT04623099)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety, Depressive Symptoms
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up.
- Trial name
- AtLAS-A (NCT04245436)
- Testing
- Duloxetine, Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Stroke
Genetic and Environmental Risk Factors for Hemorrhagic Stroke-GERFHS III
The purpose of this study is to find risk factors for hemorrhagic stroke, specifically intracerebral hemorrhage (ICH). ICH, a type of bleeding into brain tissue, is a type of stroke that can result in death or disability in a…
- Trial name
- GERFHS-III (NCT00930280)
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stroke
Motor Control Physical Therapist Support Stroke
The purpose of this study is to systematically determine the effect of unnecessary physical therapist assistance in individuals after stroke during the practice of an upper limb task on an individual's task performance and their…
- Trial name
- NCT04856527
- Testing
- Physical therapist support
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Cincinnati
Post-stroke Depression
Developing an EEG Probe for Studying and Modulating Cognitive Control
This study aims to investigate effects of transcranial current stimulation (tES) and transcutaneous direct current stimulation (tsDCS) associated changes on fronto-parietal EEG and cognitive performance in patients with post…
- Trial name
- PSD (NCT05612659)
- Testing
- Transcranial Electrical stimulation, Transcutaneous direct current stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
HIV Infections
CCR5-modified CD4+ T Cells for HIV Infection
A Comparative Study of Autologous CD4+ T Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 versus ex vivo Expanded Unmodified Autologous CD4+ T Cells in Treated HIV-1 Infected Subjects
- Trial name
- TRAILBLAZER (NCT03666871)
- Testing
- SB-728-T, Expanded unmodified autologous CD4+ T cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Family Caregivers, Stroke
Caregiver Self-Management Needs Through Skill-Building
Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers.
- Trial name
- NCT03635151
- Testing
- Telephone Assessment and Skill-Building Kit (TASK III) Group, Information Support and Referral (ISR) Group
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Lymphangioleiomyomatosis
Letrozole for Lymphangioleiomyomatosis
The hypothesis in this study is that estrogen suppression by an aromatase inhibitor in postmenopausal women with lymphangioleiomyomatosis (LAM) will prevent or delay progression of lung disease and result in a decrease in the…
- Trial name
- TRAIL (NCT01353209)
- Testing
- Letrozole
- Where
- 9 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Cincinnati
Speech Sound Disorder
Simplified Ultrasound Feedback for Speech Remediation
Recent research in motor control shows that people learn new movements best when they receive feedback external to the body. Traditional ultrasound speech therapy works well for many children, but involves teaching children to…
- Trial name
- SUFSR (NCT06366256)
- Testing
- Traditional ultrasound biofeedback, Simplified ultrasound biofeedback
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Epilepsies, Partial
Effects of Diazepam on RNS Detections
To assess the magnitude and duration of reduction in RNS recorded Detections and Long Episodes following intranasal administration of Valtoco®.
- Trial name
- NCT05273398
- Testing
- nasal diazepam
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
COVID-19
Sirolimus Treatment in Hospitalized Patients With COVID-19 Pneumonia
The main objective of our study is to determine if treatment with sirolimus can improve clinical outcomes in hospitalized patients with COVID-19.
- Trial name
- SCOPE (NCT04341675)
- Testing
- Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Cincinnati
Parkinson's Disease, Small Intestinal Bacterial Overgrowth
Treating Bacterial Overgrowth in Parkinson's Disease
This study investigates the effect of treating Small Intestinal Bacterial Overgrowth (SIBO) in patients with Parkinson's Disease (PD).
- Trial name
- SIBO-PD (NCT02470780)
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati