Clinical trials: sponsored by University of Cincinnati
Head and Neck Cancer
Post-operative Radiation With Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
The standard treatment of surgery followed by radiation therapy can stop tumors from growing in the head and neck region in most patients. However, the cancer can recur or can spread to other parts of the body.
- Trial name
- NCT01979211
- Testing
- Cetuximab, Radiation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury
This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients.
- Trial name
- NCT04836481
- Testing
- Serum Sample Collection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Birt-Hogg-Dube Syndrome
Assessment of Safety of Air Travel in Patients With Birt-Hogg-Dube Syndrome
The aim of this study is to conduct survey-based assessments for the safety of air travel in patients with Birt-Hogg-Dube syndrome (BHD).
- Trial name
- NCT03040115
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Pulmonary Langerhans Cell Histiocytosis
Assessment of Safety of Air Travel in Patients With Pulmonary Langerhans Cell Histiocytosis
The aim of this study is to conduct survey-based assessments for the safety of air travel in patients with pulmonary Langerhans cell histiocytosis (PLCH).
- Trial name
- NCT03052101
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Cincinnati
ACL Injury
Molecular Imaging Assessment of ACL Viability
The objective of this study is to answer the following questions: 1. Does the appearance of the reconstructed anterior cruciate ligament (ACL) vary in appearance on PET/MRI depending on graft type and time after surgery? 2.
- Trial name
- NCT03491046
- Testing
- PET scan, MRI scan
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Cincinnati
Portable Ultrasound
Exploring New and Next Generation Ultrasound Technologies for Medical Education, Patient Care, and New Indications
This is a Phase I study to assess feasibility. There will be no impact on clinical care based on this study. The ultrasound system is FDA approved and could be used for clinical care independent of this research study.
- Trial name
- NCT03486444
- Testing
- Phillips Lumify Diagnostic Ultrasound System, Surveys
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Medical Imaging Data
The Wright Center of Innovation Imaging Archive
This data bank will serve as a data resource for a multidisciplinary team of clinicians and basic scientists. Specifically, this data bank will allow investigators to generate preliminary data for competitive consideration in…
- Trial name
- WIIA (NCT05074537)
- Testing
- MRI exam, PET/CT imaging exam, CT imaging exam
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Cincinnati
Perception of Imaging
Online Surveys to Assess the Perception and Performance of Imaging and Associated Aspects
In this exploratory study, the researchers would like to investigate the background, perception, current use practices, potential unmet needs and/or challenges in regard to imaging procedures, imaging technology, or any other…
- Trial name
- NCT03494335
- Testing
- Online surveys
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cincinnati
Healthcare Facility Environment - Imaging
Assessing Environmental Factors in Healthcare Facilities in Order to Improve the Experience of Patients, Staff, and the Quality of Imaging Procedures
The purpose of this study is to assess subjects' perceptions of environmental conditions and their preferences, and to expose subjects to varied environmental conditions as well as to assess their perception and feedback to these…
- Trial name
- NCT03456895
- Testing
- Light perception, Sound perception, Smell perception
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Perforator Flap Surgery
Comprehensive Imaging of Perforator Vessels and Subcutaneous Vascular Network With No-Exogenous Contrast and Non-Ionizing-Radiation Magnetic Resonance Angiography
In this study the investigators plan to enroll a total of 25 evaluable volunteers (volunteer population) for the development and optimization of perforator imaging protocols and 50 evaluable clinical patients receiving flap…
- Trial name
- NCT03567018
- Testing
- MRI Scan
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
PET/CT Imaging
Validating Low FDG Dose PET/CT Compared to Current Standard of Care Dose PET/CT
The purpose of this study is to assess new low radiation dose techniques for clinical PET/CT scans through intra-individual comparison between a clinical, standard dose scan and a low-dose scan, completed within one week of each…
- Trial name
- NCT03519659
- Testing
- PET/CT scan with 13 mCi radiation dose, PET/CT scan with 5 mCi radiation dose, PET/CT scan with 2.5 mCi radiation dose
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Cincinnati
E-cigarette Use
Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use
The investigators aim to (1) establish a methodology for the evaluation of the biodistribution of radio-labeled nicotine following e-cigarette use, (2) determine the oral/pulmonary distribution of nicotine following e-cigarette…
- Trial name
- NCT03491059
- Testing
- C-11 labeled nicotine, PET/CT imaging
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
PET Imaging
Assessment of Investigational Positron Emission Tomography and Post-Processing Procedures Performed as Add-ons to Standard of Care Imaging
The goals of this study are to (1) develop and refine PET post-processing acquisition procedures, (2) generate preliminary and comparative imaging data for potential clinical trials, and (3) retrospectively evaluate standard of…
- Trial name
- NCT03490812
- Testing
- PET scan, Retrospective data analysis
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Cincinnati
MRI Imaging
Assessment of Investigational Magnetic Resonance Imaging and Post-Processing Procedures
The goals of this study are to (1) develop and optimize MRI acquisition and post-processing techniques and (2) to generate preliminary and comparative data on sequences for potential clinical trials.
- Trial name
- NCT03490656
- Testing
- MRI Scan - in addition to standard of care, MRI Scan - not in addition to standard of care
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
New-generation Digital PET/CT Imaging
Feasibility Assessment of Next-generation PET Technology and Procedures
The purpose of this study is to assess the feasibility of investigational Positron Emission Tomography (PET) imaging using the new generation digital detector PET technology for new procedures beyond the current standard of care.
- Trial name
- NCT03387618
- Testing
- Digital PET/CT imaging
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- University of Cincinnati
Mammoplasty Patient
Evaluation of Perforator Phase Contrast Angiography in Developing Surgery Plans for Patients With Breast Cancer Undergoing Breast Reconstruction With Free-Flap Methods After Mastectomy
This phase II trial studies how well an imaging technique called perforator phase contrast angiography (pPCA) works in developing surgery plans for patients with breast cancer undergoing breast reconstruction after breast removal…
- Trial name
- NCT04063410
- Testing
- Angiography, MRI-Based Angiogram, Quality-of-Life Assessment
- Where
- United States
- Sponsor
- University of Cincinnati
Coronary Artery Disease
Impact of Health Literacy on Outcomes and Effectiveness of Shared Decision Making Programs in Patients With Chronic Diseases
Study objective was to explore the impact of health literacy on effectiveness of an educational intervention describing life-style and behavior modification for patients "Living with Coronary Artery Disease." Our hypothesis was…
- Trial name
- NCT01083862
- Testing
- Educational Intervention - Text plus DVD/VHS, Educational Intervention - Text Only
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- University of Cincinnati
Lymphangioleiomyomatosis
Efficacy and Safety of Sirolimus in LAM
Lymphangioleiomyomatosis (LAM) is a rare lung disease of women that is caused by genetic mutations. It results in the uncontrolled growth of an unusual type of smooth muscle cell in the lung.
- Trial name
- MILES (NCT00414648)
- Testing
- Sirolimus
- Where
- 13 sites in United States, Canada and 1 more
- Volunteers
- 89 people
- Sponsor
- University of Cincinnati
Acute Stroke, Endovascular Thrombectomy
Blood Pressure After Endovascular Stroke Therapy-II
The purpose of this study is to assess the safety of lowering blood pressure in acute stroke patients that are successfully treated with a mechanical thrombectomy procedure.
- Trial name
- BEST-II (NCT04116112)
- Testing
- Nicardipine, Labetalol, Hydralazine
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati