Clinical trials: sponsored by University of Cincinnati
HIV Infections
Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection
The purposes of this study are: 1. To understand whether the use of HIV therapy in persons with more advanced HIV disease results in greater side effects. 2.
- Trial name
- NCT00885664
- Testing
- Truvada (tenofovir/emtricitabine), Kaletra (lopinavir/ritonavir)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Hypertension, Pre-Hypertension
Modifying Dietary Behavior in Adolescents With Elevated Blood Pressure
The purpose of this study is to examine the long term effects of a 24-week clinically-based behavioral nutrition intervention emphasizing the DASH diet compared to routine nutrition care on changing diet quality, blood pressure…
- Trial name
- DASH-4-Teens (NCT00585832)
- Testing
- DASH-4-Teens, Routine Care
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Cincinnati
Pancreatic Cancer
Neoadjuvant Stereotactic Body Radiation Therapy for Resectable Adenocarcinoma of the Pancreatic Head and/or Body
The purpose of this study is to test the safety of focused radiation (Stereotactic Body Radiation Therapy, SBRT) on patients with pancreatic cancer that will be removed surgically.
- Trial name
- NCT02208024
- Testing
- Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Blunt Chest Wall Trauma, Rib Fracture
Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma
This is a study of liposomal bupivacaine for pain control in patients with blunt chest wall trauma.
- Conditions
- Blunt Chest Wall Trauma, Rib Fracture, Sternal Fracture
- Trial name
- NCT02749968
- Testing
- Liposomal bupivacaine, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Cincinnati
Attention Deficit Disorder
Effect of Omega-3 Fatty Acid on Cortical Function in ADHD
The study hypothesis is that DHA is more effective than placebo in increasing brain activation and reducing symptoms in psychostimulant-free children with ADHD.
- Trial name
- NCT01883817
- Testing
- DHA Omega-3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Obesity, Hypertension
Supermarket and Web-Based Intervention Targeting Nutrition (SuperWIN) for Cardiovascular Risk Reduction
The Supermarket and Web-based Intervention targeting Nutrition (SuperWIN) for cardiovascular risk reduction is a novel, randomized controlled trial aimed at increasing diet quality and decreasing cardiovascular risk.
- Conditions
- Obesity, Hypertension, Hyperlipidemias, Diet Modification
- Trial name
- SuperWIN (NCT03895580)
- Testing
- In-store POP education, Online POP education
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- University of Cincinnati
HIV Infections
Darunavir/Ritonavir and Rosuvastatin Pharmacokinetic Study
This is a phase I, open-label, controlled drug interaction study to determine the effects of darunavir plus ritonavir on the pharmacokinetics of the hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, rosuvastatin, in…
- Trial name
- NCT00885495
- Testing
- darunavir, ritonavir, rosuvastatin, rosuvastatin, darunavir, ritonavir
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Osteoarthritis, Hip
KINCISE™ Surgical Automated System in Total Hip Arthroplasty (THA)
There is a growing interest in the effects of mental health and wellness on orthopedic intervention outcomes, not only in terms of how advances in surgical procedures influence patient outcomes, but also with regard for physician…
- Trial name
- NCT05223777
- Testing
- KINCISE, Traditional Handheld Mallet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Health Behavior
Evaluating the Impact of Vocal Health Education on Mask-wearing Workers During COVID-19
The purpose of this clinical trial is to understand how viewing educational health modules impacts vocal health behaviors in mask-wearing healthcare workers.
- Trial name
- NCT04858542
- Testing
- Educational Vocal Health Modules
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Traumatic Injury, Venous Thromboembolism
Evaluation of Venous Thromboembolism Prevention in High-Risk Trauma Patients
This is a pilot study to determine if anti-thrombin III (AT-III) serum concentrations differ between patients with normal versus subtherapeutic anti-Xa trough concentrations when placed on enoxaparin 30 mg twice daily for VTE…
- Trial name
- NCT02412982
- Testing
- Enoxaparin 40 mg q12h, Enoxaparin 30 mg q8h
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Cincinnati
Breast Cancer
Proton Accelerated Partial Breast Irradiation
This prospective, non-randomized phase II study will evaluate the cosmetic outcome of using pencil beam scanning proton therapy for partial breast irradiation in patients diagnosed with early stage breast cancer.
- Trial name
- APBI (NCT03940248)
- Testing
- Proton Accelerated Partial Breast Irradiation
- Where
- United States
- Sponsor
- University of Cincinnati
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Dyspareunia
Fractional CO2 Laser Therapy Versus 4% Topical Lidocaine Gel for Dyspareunia in Breast Cancer Survivors
This trial seeks to determine if therapy with a CO2 laser to the vagina is more effective than lidocaine to the opening of the vagina before intercourse to reduce painful intercourse in women who are breast cancer survivors.
- Trial name
- BCLS (NCT03257670)
- Testing
- 4% Topical Lidocaine Gel, CO2RE fractional laser therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Acute Cellular Graft Rejection, New Onset Diabetes After Transplant
Budesonide for Liver Transplant Immune Suppression
This is a pilot study that investigates the efficacy and safety of budesonide as an immune suppressing agent for liver transplant recipients in the early post-transplant period.
- Trial name
- NCT03304626
- Testing
- Budesonide 3Mg Capsule, Standard of Care Prednisone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Primary Renal Allograft
Study to Evaluate Safety and Efficacy of Early Calcineurin Inhibitor Withdrawal in Primary Renal Allografts
Evaluate the safety and efficacy of early corticosteroid withdrawal and simultaneous calcineurin inhibitor withdrawal in recipients of primary renal allografts maintained long-term on MMF and sirolimus.
- Trial name
- NCT00374647
- Testing
- mycophenolate mofetil, sirolimus
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Cincinnati
Chronic Pain, Ankle Fracture Surgery
Anesthesia for Pain After Ankle Fracture Surgery
This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture compared to standard of care.
- Conditions
- Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
- Trial name
- NCT02950558
- Testing
- Ropivacaine, Nerve block
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Cincinnati
Liver Failure, Liver Transplant; Complications
Telemedicine Based Remote Home Monitoring After Liver Transplantation
A significant opportunity exists to involve patients and their caregivers in more effective perioperative care and transition to home for transplant patients.
- Trial name
- TelehealthOLT (NCT03878329)
- Testing
- remote home monitoring
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Kidney Transplant Rejection
Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation (BETTER Trial)
This study is designed to determine the safety and efficacy of two calcineurin inhibitor free treatment groups 1) a belatacept, everolimus and early corticosteroid withdrawal (ECSWD) immunosuppressive regimen with rabbit…
- Trial name
- BETTER (NCT04849533)
- Testing
- Belatacept, Everolimus, mycophenolate mofetil
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
Acute Pancreatitis
Ketorolac in Acute Pancreatitis
This study will compare pain management strategies for patients hospitalized with acute pancreatitis. Standard of care pain management will be compared to standard of care plus intravenous ketorolac.
- Trial name
- NCT04282200
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety
Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents With Anxiety
Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents with Anxiety. To determine the effects of escitalopram on functional activation patterns during a Continuous Performance Task with Emotional and Neutral…
- Trial name
- FiESTAA (NCT02818751)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati