Clinical trials: sponsored by University of Cincinnati
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Head and Neck Cancer
Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma
The purpose of this research study is to test the safety of adding metformin to standard of care. The standard of care treatment will be cisplatin once every 3 weeks for 3 treatments and radiation for 7 weeks.
- Trial name
- NCT02325401
- Testing
- Metformin, Cisplatin, Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)
An open label study to assess the safety, tolerability, and effects of intranasal Ketamine in combination with rTMS for patients with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT04352621
- Testing
- intranasal ketamine, rTMS treatment
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Sarcoidosis
Patient Reported Outcome Instruments in Sarcoidosis
Evaluate change of quality of life of sarcoiodosis patients over a six months using various quality of life instruments including a monthly smart phone app.
- Trial name
- OSAP-PRO (NCT04342403)
- Testing
- Quality of Life
- Where
- 3 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Cincinnati
Coronary Artery Disease, Human Immunodeficiency Virus (HIV)
Pericardial Fat and Inflammation in HIV Patients and Controls
The investigators propose to correlate 1) cardiac MRI pericardial adipose volume, 2) the presence of pericardial monocytes and 3) circulating immune biomarkers in persons with and without CHD and HIV infection compared to…
- Trial name
- NCT02399384
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Myelodysplastic Syndrome
The Role of Erlotinib an Epidermal Growth Factor Receptor (EGFR) Inhibitor in the Treatment of Myelodysplastic Syndrome
The purpose of this research study is to find out what effects, good and/or bad, Erlotinib has on Myelodysplastic syndrome. Myelodysplastic syndrome is a group of blood diseases where the bone marrow (spongy space in long bones…
- Trial name
- NCT00570375
- Testing
- Erlotinib
- Where
- United States
- Sponsor
- University of Cincinnati
Pancreatic Adenocarcinoma
Phase II Study Of Neoadjuvant Chemotherapy In Borderline Resectable Pancreatic Adenocarcinoma
The goal of this study is to determine the effect of chemotherapy on decreasing the size of unresectable pancreas cancer thereby allowing it to be surgically removed.
- Trial name
- NCT00728000
- Testing
- Gemcitabine, Oxaliplatin, Erlotinib
- Where
- United States
- Sponsor
- University of Cincinnati
Thrombocytopenia
Study of Eltrombopag in Platelet Refractory Thrombocytopenia
This phase II trial is studying the effects of the drug eltrombopag has on thrombocytopenia (low platelet count). Eltrombopag is approved by the FDA for the treatment of thrombocytopenia (low platelet count) in adults who have…
- Trial name
- NCT01194167
- Testing
- Eltrombopag
- Where
- United States
- Sponsor
- University of Cincinnati
Malignant Neoplasm, Solid Tumors
Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors
The purpose of this research study is to test the safety of chloroquine in combination with carboplatin and gemcitabine and see what effects (good and bad) it has on advanced solid tumors.
- Trial name
- NCT02071537
- Testing
- Chloroquine, Carboplatin, Gemcitabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Glioblastoma Multiforme
Surgery With Implantable Biodegradable Carmustine (BCNU) Wafer Followed by Chemo for Patients With Recurrent Glioblastoma Multiforme
The purpose of this research study is to try and identify a more effective treatment plan to improve survival rates for patients with a recurrent Glioblastoma Multiforme (GBM) brain tumor that can be removed by brain surgery.
- Trial name
- NCT00984438
- Testing
- BCNU Wafer, Irinotecan, Bevacizumab
- Where
- United States
- Sponsor
- University of Cincinnati
Head and Neck Cancer
Safety Study of SBRT and Docetaxel for Locally Recurrent or Second Primary Squamous Cell Carcinoma of the Head and Neck
The purpose of this research study is to test the safety of a chemotherapy drug called docetaxel and focused radiation therapy (SBRT) and see what effects (good and bad) it has on recurrent head and neck cancer that is not…
- Trial name
- NCT02110992
- Testing
- Docetaxel, Stereotactic Radiation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Cincinnati
Mania
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
The purpose of this study is to see if taking a substance called omega-3 fatty acids is effective, safe, and well-tolerated for treating adolescents with major depressive disorder (also called simply "depression" or "clinical…
- Trial name
- R34 (NCT00917501)
- Testing
- OMega 3
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Post-stroke Aphasia, Aphasia
Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia
The currently available interventions only partially restore language abilities in patients with post-stroke aphasia; preventing successful reintegration into society.
- Trial name
- NAIL (NCT04081207)
- Testing
- AAC for Language Recovery (AAC-LaRc)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Cancer of the Prostate, Castration-resistant Prostate Cancer
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer
The purpose of this research study is to test to see if Gadoxetate Sodium is a useful contrast agent for detecting prostate cancer during magnetic resonance imaging (MRI).
- Trial name
- NCT03960788
- Testing
- Gadoxetate Sodium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Disorder of Shoulder
Rehabilitative Ultrasound Imaging: Measurements of Articular Movement of the Shoulder
The purpose of this study is to measure the amount of movement between the bones of the shoulder joint when mobilization techniques are applied by a physical therapist.
- Trial name
- NCT02338791
- Testing
- Manual Mobilization
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Drug Mechanism
Pharmacokinetics and Pharmacodynamics of Extended-Infusion Cefepime in Continuous Renal Replacement Therapy
This prospective, multi-center study aims to determine the pharmacokinetics and pharmacodynamics of extended-infusion cefepime in continuous renal replacement therapy (CRRT).
- Trial name
- NCT02458261
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Opioid-use Disorder, IV Drug Usage
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
The purpose of this research study is to: 1. assess how participants like the AWAITS e-health application as measured by their feedback on the intervention 2.
- Conditions
- Opioid-use Disorder, IV Drug Usage, Overdose, Drug Addiction
- Trial name
- AWAITS (NCT03402672)
- Testing
- self-administered, e-health application
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Opioid-Related Disorders, Opioid-use Disorder
RETAIN: Retaining Opioid Users Entering Medication Assisted Treatment and Encouraging HCV/HIV Testing
The purpose of this research study is to: 1. assess how well individuals entering medication assisted treatment like the RETAIN e-health application as measured by their feedback on the intervention. 2.
- Conditions
- Opioid-Related Disorders, Opioid-use Disorder, Drug Addiction, Substance Use Disorders
- Trial name
- RETAIN (NCT03411265)
- Testing
- self-administered, e-health application
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Stroke
Mechanisms of Walking Recovery After Stroke
Subjects with stroke will have behavioral testing and brain imaging before and after a 4-week control period and a 4-week exercise intervention.
- Trial name
- NCT02858349
- Testing
- No intervention, High-intensity interval training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Red Cell Survival in Healthy Volunteers
Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
The pilot study has two objectives: 1) to assess the post-infusion viability of INTERCEPT RBC by measuring the 24 hour post-infusion recovery ("PTR24") and lifespan of autologous RBCs prepared with the INTERCEPT System for RBC…
- Trial name
- BIO-CR-RBC (NCT03384407)
- Testing
- Red cell survival in INTERCEPT treated red cells
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati