Clinical trials: sponsored by University of Cincinnati
Recurrent Head and Neck Cancer, Head and Neck Cancer
Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
The purpose of this research study is to test the combination of the anti-cancer drugs durvalumab, the study drug, and cetuximab as a treatment for metastatic or recurrent head and neck cancer.
- Conditions
- Recurrent Head and Neck Cancer, Head and Neck Cancer, Head and Neck Neoplasms, Metastatic Cancer
- Trial name
- NCT03691714
- Testing
- Durvalumab, Cetuximab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Cincinnati
Binge-Eating Disorder, Circadian Rhythm Disorders
The Role of the Circadian System in Binge Eating Disorder
Binge eating disorder (BED) shows prominent circadian features that suggest a delay in circadian phase, and preliminary evidence shows binge eating may be responsive to chronobiological interventions, implicating a circadian…
- Trial name
- CHRONO-BE (NCT04724668)
- Testing
- Melatonin (3hrs before DLMO), Morning light version 1, Morning light version 2
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Renal Transplantation
Belatacept Early Steroid Withdrawal Trial
The study purpose is to determine the safety and efficacy of a belatacept-based immunosuppressive regimen (calcineurin inhibitor free) with alemtuzumab or rabbit antithymocyte globulin (rATG) induction and early glucocorticoid…
- Trial name
- NCT01729494
- Testing
- Alemtuzumab, rabbit antithymocyte globulin, Belatacept
- Where
- 8 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Cincinnati
Hepatocellular Carcinoma, Cirrhosis
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
Immunotherapy can safely downstage patients and achieve durable systemic disease control to improve clinical outcomes in HCC patients undergoing liver transplant.
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Portal Hypertension
- Trial name
- NCT05027425
- Testing
- Durvalumab, Tremelimumab, Liver Transplant
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Premature Infant Disease, Family Research
PREEMIE PROGRESS: A Family Management Program for Parents of Preterm Infants
The purpose of this study is to refine and pilot test a mobile health (mHealth), video-based family management program for parents of preterm infants hospitalized in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Premature Infant Disease, Family Research, Parent-Child Relations, Self Efficacy
- Trial name
- NCT04638127
- Testing
- PREEMIE PROGRESS, Attention Control
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Dysphagia, Oral Phase, Stroke, Ischemic
Lingual Endurance Exercise in Treating Post-Stroke Dysphagia
Aim 1: Determine feasibility of lingual endurance training for individuals with persistent dysphagia after ischemic stroke. Primary outcome measures: % patient adherence (# of attempted repetitions/# prescribed repetitions) and %…
- Trial name
- NCT05523973
- Testing
- Lingual Endurance Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
Inhaled Nitric Oxide in Brain Injury
This study will evaluate the changes in respiratory mechanics following traumatic brain injury and determine the effect of inhaled nitric oxide on gas exchange.
- Trial name
- NCT03260569
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Stroke
Moderate-Intensity Exercise Versus High-Intensity Interval Training to Recover Walking Post-Stroke
The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke.
- Trial name
- NCT03760016
- Testing
- Moderate-Intensity Aerobic Training, High-Intensity Interval Training
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Cincinnati
Pediatric Obesity
Healthy Eating for My Infant (HEMI)
Infants from underserved and minority backgrounds are at increased risk for obesity and poor feeding and nutrition outcomes, but obesity prevention programs tailored specifically to the needs of these infants are lacking.
- Trial name
- NCT04977947
- Testing
- Healthy Eating for My Infant
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Spinal Cord Stimulation for the Treatment of Major Depressive Disorder
This pilot clinical trial will evaluate the efficacy and safety of transcutaneous direct current stimulation (tsDCS) in major depressive disorder.
- Trial name
- SPIDEP (NCT03433339)
- Testing
- Active transcutaneous spinal direct current stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
BLS Competence, Debriefing
The Effect of Immediate Versus Delayed Debriefing on Basic Life Support Competence In Undergraduate Nursing Students.
The goal of this clinical trial is to find out if immediate (hot) or delayed (cold) debriefing is better for undergraduate nursing students during Basic Life Support (BLS) training.
- Trial name
- NCT06624449
- Testing
- Cold debriefing, Hot Debriefing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Complication of Transplant
Conversion From Brand to Generic Tacrolimus in High Risk Transplant Recipients
The prospective study will compare the relative bioavailability at steady-state pharmacokinetics of 6 tacrolimus formulations in a prospective, 6-way cross-over study including CYP3A5 expressors (n=30) and non-expressor (n=30)…
- Trial name
- NCT02014103
- Testing
- Prograf, Tacrolimus, Sandoz, Tacrolimus, Reddy Laboratory
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Cincinnati
Pre-hospital Ventilation
Ability of Caregivers to Provide Ventilation With the SAVe Resuscitator in a Model
This study will compare three methods of delivering mechanical ventilation using a test lung. Ventilation will be delivered using (1) a mask held in place by a caregiver, (2) a mask strapped to the model using a securing device…
- Trial name
- NCT01477710
- Testing
- Hold mask, Strap Mask, Airway
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Glioblastoma
Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma
The purpose of this research study is to see if people can produce ketones in their blood with the modified Atkins diet. Modified Atkins diet is a diet that produces ketones in your blood by restricting carbohydrates to <20 grams…
- Trial name
- NCT03278249
- Testing
- Modified Atkins Ketogenic Diet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Stroke
Motor Control Physical Therapist Support Stroke
The purpose of this study is to systematically determine the effect of unnecessary physical therapist assistance in individuals after stroke during the practice of an upper limb task on an individual's task performance and their…
- Trial name
- NCT04856527
- Testing
- Physical therapist support
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Cincinnati
Family Caregivers, Stroke
Caregiver Self-Management Needs Through Skill-Building
Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers.
- Trial name
- NCT03635151
- Testing
- Telephone Assessment and Skill-Building Kit (TASK III) Group, Information Support and Referral (ISR) Group
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Lymphangioleiomyomatosis
Letrozole for Lymphangioleiomyomatosis
The hypothesis in this study is that estrogen suppression by an aromatase inhibitor in postmenopausal women with lymphangioleiomyomatosis (LAM) will prevent or delay progression of lung disease and result in a decrease in the…
- Trial name
- TRAIL (NCT01353209)
- Testing
- Letrozole
- Where
- 9 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Cincinnati
COVID-19
Sirolimus Treatment in Hospitalized Patients With COVID-19 Pneumonia
The main objective of our study is to determine if treatment with sirolimus can improve clinical outcomes in hospitalized patients with COVID-19.
- Trial name
- SCOPE (NCT04341675)
- Testing
- Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Cincinnati
Parkinson's Disease, Small Intestinal Bacterial Overgrowth
Treating Bacterial Overgrowth in Parkinson's Disease
This study investigates the effect of treating Small Intestinal Bacterial Overgrowth (SIBO) in patients with Parkinson's Disease (PD).
- Trial name
- SIBO-PD (NCT02470780)
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati