Clinical trials: sponsored by University of Colorado, Denver
Asthma in Children
BiPAP in Pediatric Moderate to Severe Asthma Randomized Control Trial
The goal of this clinical trial is to study if starting bi-level positive airway pressure (BiPAP), a mask that gives pressure to the lungs, works well for children in the emergency department with moderate to severe asthma…
- Trial name
- NCT05848115
- Testing
- Bi-level Positive Airway Pressure
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Colorado, Denver
Hematologic Disorders
Haploidentical CD34+ Selected Cells Combined With Single Unit Umbilical Cord Blood Transplant for Treatment of High-risk Hematologic Disorders
This is a study to evaluate the safety and efficacy of Miltenyi CliniMACS® CD34 Reagent System to promote engraftment of haploidentical CD34+ selected cells combined with single unit umbilical cord blood transplant for treatment…
- Trial name
- NCT03093844
- Testing
- Miltenyi CliniMACS® CD34 Reagent System
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Sepsis, Diagnosis
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
Sepsis is a leading cause of death in children, and an early diagnosis that improves outcomes is less likely in children who are treated in general Emergency Departments (EDs), that treat adults and children, compared to…
- Conditions
- Sepsis, Diagnosis, Emergencies
- Trial name
- RightCall (NCT07051668)
- Testing
- Pediatric Sepsis Diagnostic Toolkit
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Bladder Cancer
Decision Making for Urinary Diversion in Patients With Bladder Cancer
This proposal will aim to improve the understanding about the treatment decision in the type of urinary diversion and identify patient knowledge gaps about uncertainty around patient decision-making.
- Trial name
- NCT05111639
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Osteoporosis
PTH And Calcium Responses to Exercise in Older Adults Experiment 2 (PACE Sr. 2)
Declines in serum calcium during exercise may cause increases in markers of bone resorption. This study will determine if preventing the decline serum ionized calcium experienced at the onset of exercise through the use of a…
- Trial name
- NCT02580604
- Testing
- Calcium Chloride/Calcium Gluconate, Half-Normal Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cancer
Evaluating a New Gonadotoxic Risk Stratification System
The primary objective of this study is to assess if there is an association between a newly described gonadotoxic risk stratification system and post-treatment ovarian reserve as determined by FSH and AMH.
- Trial name
- NCT05052632
- Sponsor
- University of Colorado, Denver
Autosomal Dominant Polycystic Kidney, Overweight and Obesity
Daily Caloric Restriction in ADPKD
This clinical trial will determine whether a daily-caloric restriction-based weight loss intervention can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese.
- Trial name
- NCT04907799
- Testing
- Daily caloric restriction, Standard advice control
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Colorado, Denver
PreDiabetes
Prevention and Choice for Type 2
People living with prediabetes are advised to lose weight to prevent development of type 2 diabetes by participating in intensive lifestyle interventions (ILI's), such as PreventT2.
- Trial name
- PACT2 (NCT06377020)
- Testing
- PACT2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Surgical Abortion, Patient Satisfaction
Effects of Aromatherapy on Patient Satisfaction With Surgical Abortion at Less Than 10 Weeks Gestation
The investigators propose a single-site, double-blinded, placebo-controlled clinical trial of lavender aromatherapy versus placebo for patient satisfaction in adult women having a surgical abortion before 10 weeks and 0 days…
- Conditions
- Surgical Abortion, Patient Satisfaction, Anesthesia, Pain
- Trial name
- NCT04969900
- Testing
- Lavender oil.
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pre-diabetes
Breaking up Sedentary Time to Improve Glucose Control in a Population at Risk for Developing Type 2 Diabetes
Newly released guidelines recommend increased physical activity (PA) and reduced sedentary behaviors (SB) to improve glycemia and prevent the onset and progression of type 2 diabetes (T2D).
- Trial name
- BURST2D (NCT05041491)
- Testing
- BREAK, ONE
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Dysfunctional Voiding
Use of an Educational Video to Improve Adherence to Treatment in Voiding Dysfunction
This study aims to see whether an educational video on a common urinary dysfunction leads to improved parent and child perceived adherence to treatments recommendations.
- Trial name
- NCT06909552
- Testing
- Educational Video on Voiding Dysfunction
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Adverse Childhood Experiences
Implementation of Adverse Childhood Experiences (ACEs) Policy
Adverse Childhood Experiences (ACEs) are pervasive among children with 45% experiencing at least one ACE and 10% experiencing three or more, placing them at high risk for toxic stress and symptomatology.
- Trial name
- NCT04916587
- Testing
- Implementation Strategy of ACEs Screenings, Usual Care
- Where
- United States
- Volunteers
- 7,645 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fetal Growth Restriction
Maternal Left Lateral Position in Fetal Growth Restriction
The goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction.
- Trial name
- NCT06919692
- Testing
- Left lateral recumbent positioning
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Nicotine Vaping
Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping
The goal of this pilot study is to determine the feasibility of a randomized trial of the YES-CAN! (Youth Engaged Strategies to Change Adolescent Norms) program to prevent nicotine vaping among adolescents.
- Trial name
- YES-CAN! (NCT07009509)
- Testing
- YES-CAN! program
- Where
- United States
- Volunteers
- 1,166 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Developmental Dysplasia of Hip
Should Graf IIc Hips be Treated for 12 Weeks
Children who are diagnosed with Developmental Hip Dysplasia (DDH) are often categorized depending on the severity of their hip malformation. Regardless of the severity, the accepted form of treatment is the Pavlik Harness.
- Trial name
- NCT03275805
- Testing
- Duration of Pavlik Harness treatment, 12 week standard of care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Myasthenia Gravis Crisis, Myasthenia Gravis Exacerbations
Treatment of Myasthenia Gravis Exacerbation or Crisis With Efgartigimod
This study plans to learn more about if the drug efgartigimod can be used in the hospital to treat exacerbations in participants with myasthenia gravis (MG).
- Conditions
- Myasthenia Gravis Crisis, Myasthenia Gravis Exacerbations, AChR Myasthenia Gravis
- Trial name
- NCT06860633
- Testing
- Efgartigimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Terminal Cancer, Metastatic Cancer
Advanced Planning for Online Accounts and Data
The proposed research consists of engagements with terminal cancer patients and their friends and family as they engage in end-of-life planning.
- Trial name
- NCT05222308
- Testing
- Post-Mortem Plan
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Migraine, Migraine in Adolescence
Mindfulness-Based Intervention for Adolescents With Chronic Migraine
The goal of this study is to assess feasibility and acceptability of a mindfulness-based intervention adapted for adolescents with migraine to inform a future randomized trial assessing effects of the intervention on…
- Trial name
- NCT06414109
- Testing
- BREATHE-Migraine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Chronic Back Pain, Chronic Pain
Feasibility and Acceptability of Group Pain Reprocessing Therapy for Veterans With Chronic Neck/Back Pain
The investigators are conducting a trial that evaluates the feasibility of telehealth group pain reprocessing therapy (PRT), with no comparison group, for the treatment of chronic back pain in a population of veterans.
- Conditions
- Chronic Back Pain, Chronic Pain, Neck Pain, Back Pain
- Trial name
- ESPRIT (NCT06406699)
- Testing
- Pain Reprocessing Therapy (PRT)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Squamous Cell Carcinoma of the Head and Neck
Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma
This is a multi-center, prospective, single-arm phase I/Ib safety trial. Patients eligible for treatment must be diagnosed with non-metastatic, biopsy-proven stage II-IVB oral cavity, stage III-IVB larynx and hypopharynx, or…
- Trial name
- NCT03635164
- Testing
- Durvalumab, Stereotactic Body Radiation Therapy (SBRT), Standard of Care Therapy
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
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