Clinical trials: sponsored by University of Colorado, Denver
Metabolic Acidosis, Kidney Transplant; Complications
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients
Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality.
- Conditions
- Metabolic Acidosis, Kidney Transplant; Complications, Vascular Diseases
- Trial name
- NCT05005793
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Mental Health Care
Process Mapping to Optimize Child Psychosocial Screenings in Primary Care, and Increase Family Service Linkages
Many families screened in primary care for social challenges to identify psychosocial needs of caregivers and children do not receive the follow-up support they need.
- Trial name
- CARELOOP (NCT06989476)
- Testing
- CARELOOP Intervention
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Colorado, Denver
Obesity, Morbid, Bariatric Surgery
Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds
The goal of this pilot study is to establish the feasibility and initial efficacy of the combination of phentermine and topiramate for adolescents and young adults who require additional risk reduction after bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery, Adolescent, Young Adult
- Trial name
- NCT04095104
- Testing
- Phentermine, Immediate Release Topiramate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Posttraumatic Stress Disorder
Administration of Prazosin to Prevent PTSD in Adult Women After Sexual Assault
This study plans to learn more about whether taking the medication, Prazosin, immediately and during the weeks immediately following a traumatic event can help to reduce the risk of developing posttraumatic stress disorder…
- Trial name
- NCT03997864
- Testing
- Prazosin
- Where
- United States
- Sponsor
- University of Colorado, Denver
Kidney Transplant; Complications, Postoperative Residual Curarization
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery
The purpose of this study is to compare two medications that reverse muscle paralysis at the end of kidney transplant surgery with the goal of reducing residual muscle weakness and insufficient respiratory function after surgery.
- Conditions
- Kidney Transplant; Complications, Postoperative Residual Curarization, Postoperative Residual Weakness
- Trial name
- NCT03923556
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury, Hemolysis
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery.
- Conditions
- Acute Kidney Injury, Hemolysis, Thrombocytopenia, Surgery
- Trial name
- NCT06349577
- Testing
- Non-pulsatile blood flow, Pulsatile blood flow
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Colorado, Denver
PTSD, Firearm Injury
Project Safe Guard-Trauma
The goal of this randomized controlled trial is to determine if a counseling intervention, Project Safe Guard-Trauma (PSG-T), increases secure firearm storage practices in adults who screen positive for posttraumatic stress…
- Conditions
- PTSD, Firearm Injury, Suicide Prevention, Firearm Safety
- Trial name
- PSG-T (NCT06876740)
- Testing
- Project Safe Guard - Trauma, Project Safe Guard
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Colorado, Denver
Non Hodgkin Lymphoma
Study of Feasibility and Safety of UCD19 Chimeric Antigen Receptor (CAR) T Cells in Adult Subjects With Relapsed/Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (B-NHL)
This study will test whether immune cells modified to recognize B-cell non-Hodgkin lymphoma (NHL) can be successfully manufactured at the University of Colorado Anschutz and whether these cells can be administered with an…
- Trial name
- NCT04240808
- Testing
- UCD19 CAR T Cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Myocardial Ischemia, Critical Illness
Bright Light Exposure in Surgical Patients
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and…
- Conditions
- Myocardial Ischemia, Critical Illness, Endothelial Dysfunction
- Trial name
- NCT03822949
- Testing
- Day Light, ICU Intense Light
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer
This randomized phase II trial compares enzalutamide with standard androgen deprivation therapy in reducing incidence of metabolic syndrome in patients with prostate cancer that has spread to other places in the body.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage III Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT02278185
- Testing
- Enzalutamide, leuprolide acetate, goserelin acetate
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Cancer
Intervention to Educate and Improve Underrepresented Populations' Participation in Clinical Trials
This proposal aims to leverage ongoing community outreach efforts and the Cancer Center's aims to improve recruitment to clinical trials by educating the catchment and making referrals to engage current UCCC patients not taking…
- Trial name
- NCT04863092
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
ADPKD, Autosomal Dominant Polycystic Kidney
Statin Therapy in Patients With Early Stage ADPKD
This study plans to learn if pravastatin is helpful in slowing down the progression of kidney disease in adults with autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT03273413
- Testing
- Pravastatin
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
COPD (Chronic Obstructive Pulmonary Disease)
Development And Evaluation of An Adaptive Web-Based Intervention for COPD
Narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with COPD. The intervention is administered by experienced LCSWs under the PI's supervision.
- Trial name
- NCT06770777
- Testing
- Tiered whole health support for people living with COPD
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Autosomal Dominant Polycystic Kidney, Obesity
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can…
- Trial name
- NCT06582875
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Colorado, Denver
Chronic Kidney Diseases, Hypertension
Inspiratory Muscle Strength Training in Chronic Kidney Disease
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney…
- Conditions
- Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure
- Trial name
- NCT04911491
- Testing
- IMST
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Methamphetamine Use Disorder
Deep Brain Stimulation (DBS) for Methamphetamine Use Disorder
We will evaluate the effects of deep brain stimulation (DBS) of bilateral nucleus accumbens (NAc) added to background treatment for treatment refractory Methamphetamine Use Disorder (MUD).
- Trial name
- NCT05558358
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Infant Development
Blueberry Intake and Infant Gut Health
The objective of this project is to investigate the effects of blueberries on gut microbiota, inflammation and innate immunity in breastfed infants during early complementary feeding (~5 to 12 months of age).
- Trial name
- NCT05006989
- Testing
- Blueberry Powder
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypoventilation, Hypoxemia
Postoperative Respiratory and Activity Monitoring
This study plans to learn more about specific breathing and activity recommendations for patients after surgery. Participants will be monitored after abdominal surgery to identify what activities help them breathe better and…
- Conditions
- Hypoventilation, Hypoxemia, Postoperative Pulmonary Complications
- Trial name
- NCT06239831
- Testing
- ExSpiron and ActivPAL Monitors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Preventive Health Services (PREV HEALTH SERV)
Presumptively Initiating Vaccines and Optimizing Talk With Motivational Interviewing (PIVOT With MI)
The overall goal of this project is to determine whether a novel and innovative provider communication strategy is effective in improving vaccine acceptance among vaccine-hesitant parents (VHPs) and visit experience among VHPs…
- Trial name
- NCT03885232
- Testing
- Experimental: PIVOT with MI, Active Comparator: Control
- Where
- 2 sites in United States
- Volunteers
- 17,446 people
- Sponsor
- University of Colorado, Denver
Obesity
Thermogenenic Responses to Fasting and Overfeeding in Women
This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain.
- Trial name
- NCT06610162
- Testing
- Eucalaloric feeding, Acute Fasting, Acute Overfeeding
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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