Clinical trials: sponsored by University of Colorado, Denver
Metastatic Renal Cell Carcinoma
Study of Pembrolizumab and Cabozantinib in Patients With Metastatic Renal Cell Carcinoma
This is a phase I/II open-label study designed to evaluate the combination of pembrolizumab and cabozantinib in subjects with locally advanced, recurrent, or metastatic renal cell carcinoma.
- Trial name
- NCT03149822
- Testing
- Cabozantinib, Pembrolizumab
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Colorado Oral Strengthening Device
University of Colorado is looking for adults with Parkinson's disease to participate in a research study. The study aims to explore how a novel low technology device can achieve an increase in tongue strength comparable to…
- Trial name
- COSD (NCT05464225)
- Testing
- COSD, SOC
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Head and Neck Cancer
Effect of Guided Imagery for Radiotherapy-Related Distress in Patients With Head and Neck Cancer
The goal of this interdisciplinary pilot study is to evaluate the feasibility, acceptability and preliminary efficacy of a guided imagery intervention to reduce radiotherapy-related symptoms of anxiety and depression in patients…
- Trial name
- NCT03662698
- Testing
- Guided Imagery, Treatment as Usual
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Chronic Pain
Acceptance and Commitment Therapy for Chronic Pain in Cancer Survivors
A study to help manage chronic pain in cancer survivors through Acceptance and Commitment Therapy (ACT) after undergoing active cancer treatment, such as surgery, chemotherapy, and/or radiation.
- Trial name
- NCT03661840
- Testing
- Acceptance and Commitment Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Post-Surgical Pain, Post-Surgical Complication
Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes
To determine how daily cannabis use affects surgical outcomes.
- Conditions
- Post-Surgical Pain, Post-Surgical Complication, Cancer, Cannabis Use
- Trial name
- NCT04988490
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Colorado, Denver
Healthy
Novel Approaches for Quantitative Assessment of Adherence
Approximately 12 adults subjects will be enrolled. Participants will be randomized to one of two directly observed dosing regimens with 2mg adenine 5+ (five stable-labeled nitrogens) as follows: 1 dose/week followed by 4…
- Trial name
- Tracer Pilot (NCT04535934)
- Testing
- Adenine 5+ (five stable-labeled nitrogens)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diastolic Dysfunction
MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women
In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function.
- Trial name
- NCT03586414
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diffuse Intrinsic Pontine Glioma
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive childhood brain tumor that, despite many past clinical trials, has never been shown to respond to chemotherapy.
- Trial name
- NCT02992015
- Testing
- Gemcitabine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
HIV, Communication Research
Information Visualizations to Enhance HIV-related Communication
HIV disproportionately affects Latinos who have more infections, faster disease progression, more HIV-related deaths, and slower diagnosis and treatment than their white/majority counterparts.
- Trial name
- Info Viz: HIV (NCT04564209)
- Testing
- Info Viz for Health
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 164 people
- Sponsor
- University of Colorado, Denver
Pediatric Neurosurgical Tumors
Sodium Fluorescein-Guided Resection of Pediatric Neurosurgical Tumors
Sodium fluorescein, which has been shown to be useful for intraoperative guidance regarding the resection of adult neurosurgical tumors, can aid the resection of pediatric neurosurgical tumors.
- Trial name
- NCT03752203
- Testing
- Sodium Fluorescein, Microscopic Resection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Obesity; Drug
Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites.
This study aims to explore how anti-obesity medications (AOMs) like semaglutide and tirzepatide affect appetite and energy intake.
- Trial name
- NCT06856928
- Testing
- Meal Challenge
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Behavioral Problem, Irritable Mood
Stop, Focus, Plan, and Change: Predicting Parent and Child Responses to a Brief, Telehealth Parent Training
This study will look at who does not improve after doing a behavioral parent training program briefly through telehealth. It will also study ways to make the intervention better for those that do not improve.
- Conditions
- Behavioral Problem, Irritable Mood, Parenting, Stress
- Trial name
- NCT06505980
- Testing
- Brief Behavioral Parenting Program
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett's Esophagus, Esophageal Cancer
TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)
A prospective outcomes study in patients with and esophageal cancer (EAC) and Barrett's esophagus (BE) associated neoplasia being evaluated for endoscopic eradication therapy (EET).
- Trial name
- NCT02634645
- Testing
- Endoscopic eradication therapies (EET), Esophagectomy, Chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bone Marrow Transplant
Remote Monitoring and Home-based Health Care for Treatment of Bone Marrow Transplant Patients
This study is designed to assess the potential for successfully using technology-assisted in-home oncology care, including remote patient monitoring (RPM), telemedicine, and home-based health care services to support improved…
- Trial name
- NCT05662631
- Testing
- BioIntellisense BioSticker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
HIV Prevention
WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women
HIV prevalence among transgender women (TW) in the United States is high (~14%). The best way to reduce HIV incidence in this population is to link TW to HIV pre-exposure prophylaxis (PrEP), which can reduce HIV transmission by…
- Trial name
- NCT06656676
- Testing
- WePrEP: A shared decision-making tool, Active comparator: CDC recommendations for discussing PrEP
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Squamous Cell Carcinoma of Head and Neck
sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC
This is a Phase I dose-escalation study of sEphB4-HSA in combination with chemotherapy, cetuximab and radiotherapy (RT). The purpose is to estimate the maximum tolerated dose (MTD) that can be administered concurrently with…
- Trial name
- NCT04091867
- Testing
- sEphB4-HSA with chemotherapy, Cetuximab, Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Cancer, Overweight and Obesity
Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors
This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise…
- Trial name
- NCT05558384
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Leukemia
Oncology Care at Home for BMT and CAR-T
To assess the potential for successfully using technology-assisted in-home oncology care to provide improved care coordination and management, and appropriate referral to treatment for patients receiving bone marrow transplant…
- Trial name
- NCT05826288
- Testing
- BioIntelliSense BioButton Rechargable, Memora Health two-way patient engagement platform provided by RC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Toddlers 12-36 Months of Age With Mild or Moderate Malnutrition
Growing Up Formula Versus Nutritional Supplements: Effect on Catch up Growth, Micronutrient Status, and Solid Foods Intake in Toddlers With Mild or Moderate Malnutrition
This is a pilot study to test how a growing-up formula (GUF) compares to a common nutritional supplement (NS), which is regularly used to help toddlers (ages 12-36 months) gain weight.
- Trial name
- KEEP Growing (NCT05088590)
- Testing
- Enfagrow® Neuropro Toddler Nutritional Drink, Pediasure® Grow & Gain Protein Shake for Kids
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
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