Clinical trials: sponsored by University of Colorado, Denver
Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism
Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
The goal of this observational study is to compare endometrial stripe thickness in adolescent and young adult (AYA) patients with a uterus on estrogen replacement therapy using oral progesterone versus the etonogstrel implant for…
- Conditions
- Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism, Hormone Replacement Therapy
- Trial name
- NCT06357442
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Colorado, Denver
Overweight, Breast Cancer
Appetite and Exercise in Breast Cancer Survivors
The overall aim of this research is to investigate the acute effects of resistance exercise (REx) on the hormonal and behavioral indices of energy balance regulation in breast cancer survivors.
- Conditions
- Overweight, Breast Cancer, Obesity
- Trial name
- EARNESt (NCT04300478)
- Testing
- REx Condition First, Sedentary Control Condition First
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Low Bone Mass, Osteoporosis, Postmenopausal
DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women
To determine whether the musculoskeletal adaptations to bone-loading exercise can be significantly augmented in older women (aged 60-85) with low bone mass (osteopenia; T-scores <-1.0 and >-2.5) or moderate osteoporosis (T-scores…
- Trial name
- NCT03227458
- Testing
- DHEA, Exercise
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pre-Eclampsia
Are There Sleep-related Factors That Contribute to an Increased Incidence of Pre-eclampsia at Altitude?
Women at altitude have an increased incidence of pre-eclampsia. Populations at altitude have a greater incidence of sleep apnea. And women with sleep apnea are at increased risk of developing preeclampsia.
- Trial name
- NCT06702475
- Testing
- Home Sleep Test with Watch PAT-one
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Endothelial Dysfunction, Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs.
- Trial name
- NCT05344573
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Cardiac Disease, Bleeding Postoperative
Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels.
- Trial name
- NCT03204357
- Testing
- Fresh Autologous whole Blood, Standard of Care Expectant management of bleeding
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Hematologic Malignancy
Remote Temperature Data for Early Detection of Febrile Neutropenia
BioSticker data is remotely tracked and displayed in a report termed the BioReport for retrospective data analysis. Typically, the biosensor collects data on an interval of ~1 minute and this data is collated and reported…
- Trial name
- NCT05180838
- Testing
- BioSticker
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Gut Microbiome, Inflammation
Salmon Intake and Gut Health in Adults
The overall objective of this project is to determine the interplay of salmon as a whole food and its bioactive compound astaxanthin on gut microbiome, fecal metabolome, and inflammation in obese prediabetic individuals.
- Trial name
- NCT04792216
- Testing
- Wild Salmon, Farmed Salmon
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Hearing Loss, Hearing Aids
Innovations in Hearing Accessibility and Technology (IHAT) Study
The research will explore outcomes of different service delivery models of over-the-counter (OTC) hearing aids by comparing them to prescription hearing aids fitted by specialists in individuals with mild to moderate hearing…
- Conditions
- Hearing Loss, Hearing Aids, OTC Hearing Aids
- Trial name
- IHAT (NCT06689865)
- Testing
- HA-HCP, OTC-HCP, OTC-R
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Colorado, Denver
Health Behavior
Effects of Microbouts of Activity on Metabolic Health
Population studies suggest that time spent in sedentary behaviors is associated with all-cause mortality including obesity, diabetes, and cardiovascular diseases, independent of time spent in exercise.
- Trial name
- NCT02998892
- Testing
- Traditional Exercise Training, Daily Microbursts of Activity
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure, Heart Failure NYHA Class III
Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF)
The Narrative Intervention for Chronic Illness-Heart Failure (NICI-HF) offers an asynchronous interactive text behavioral health intervention to advance behavioral health equity by facilitating access to care for people adjusting…
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NICI-HF (NCT06097481)
- Testing
- Narrative Intervention for Chronic Illness-Heart Failure, Attention Control
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Oral Hormonal Contraceptive Use, Neural Activity
Contraceptive Hormone and Reward Measurement (CHARM Study)
Purpose of this study: The purpose of this study is to learn more about how hormonal oral contraceptives affect brain processes and emotional wellbeing.
- Conditions
- Oral Hormonal Contraceptive Use, Neural Activity, Mood, Hedonic Function
- Trial name
- CHARM (NCT05058872)
- Testing
- Levonorgestrel/ethinyl estradiol
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Peripheral T Cell Lymphoma
Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas
This regimen aims to become the first line treatment for peripheral T cell lymphoma, using nivolumab with the standard of care chemotherapy.
- Trial name
- NCT03586999
- Testing
- Nivolumab, Etoposide, Prednisolone
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Radiation Treatment, Cancer
Cardiac Effects From Radiation Therapy by MRI
The investigators will identify 10 patients in the department of radiation oncology who will receive standard of-care radiation therapy, and the treating radiation oncologist anticipates a mean left ventricular dose of at least 5…
- Conditions
- Radiation Treatment, Cancer, Cardiotoxicity
- Trial name
- NCT04486573
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Type 1 Diabetes
Feasibility of Closed-loop Automated Insulin Delivery System by Primary Care & Endocrinology, in Person & Via Telehealth
This is a study assessing the feasibility of using the insulin-only configuration of the iLet bionic pancreas with initiation in pump-naïve people with type 1 diabetes in a primary care practice with either in-person training and…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Diabetes, Autoimmune, Diabetes type1
- Trial name
- NCT05168657
- Testing
- Bionic Pancreas, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Racial/Ethnic Minorities on Dialysis
Prosperando: Fostering Resilience on Dialysis
Latinos with End-Stage Renal Disease (ESRD) represent 17% of the US adult ESRD community and suffer a disproportionate burden of social challenges that impacts their well-being.
- Trial name
- NCT03978806
- Testing
- Active Comparator: peer navigator
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pediatric Patients, Hematologic Malignancy
TCR Alpha/Beta and CD19-deplete Haplo-HSCT
This is an open label, interventional, non-randomized, phase II trial of TCR alpha/beta and CD19-depeleted allogeneic HCT in pediatric patients with hematologic disease.
- Conditions
- Pediatric Patients, Hematologic Malignancy, Other Hematologic Condition
- Trial name
- NCT05288595
- Testing
- CliniMACS Plus Instrument
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Firearm Injury
Safety Education in the Emergency Department: A Pilot Study
The purpose of this pilot study is to assess the feasibility and acceptability of video-based safe firearm storage education in the Pediatric Emergency Department.
- Trial name
- SEED (NCT05168878)
- Testing
- 30-second BeSMART video, 3-minute BeSMART video
- Where
- United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Klinefelter Syndrome
Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome
This study will learn more about how the body uses energy. Usually, the body uses sugars as energy first and then fats are used when the sugar stores are gone. Some people have trouble using fats as energy.
- Trial name
- NCT05498090
- Testing
- Fenofibrate 145 mg
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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