Clinical trials: sponsored by University of Colorado, Denver
Lung Cancer, Smoking Cessation
Shared Decision Making in Rural Primary Care Lung Cancer Screening and Smoking Cessation
The intervention is aimed to improve adherence to the lung cancer screening (LCS) guidelines and Centers for Medicare and Medicaid Services (CMS) coverage criteria to conduct shared decision-making (SDM) and provide smoking…
- Trial name
- SDM-LCS-SC (NCT04897568)
- Testing
- Patient decision aid
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Herpes Zoster
Persistence of Protection by Shingrix
The study plans to learn more about how the shingles vaccine, Shingrix (SRX), successfully prevents shingles in older people. Two vaccines are currently approved by the Food and Drug Administration (FDA) to prevent shingles.
- Trial name
- NCT04169009
- Testing
- Zostavax, Shingrix
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sudden Sensorineural Hearing Loss (SSNHL)
High Dose Oral Steroids in Sudden Sensorineural Hearing Loss
Compare hearing outcomes between treatment with dexamethasone versus prednisone in participants who have been diagnosed with unilateral SSNHL (sudden sensorineural hearing loss).
- Trial name
- NCT03255473
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Sponsor
- University of Colorado, Denver
Cannabis Smoking, Oxidative Stress
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
- Trial name
- NCT02480283
- Testing
- Bronchoscopy, Chest X-ray, Venipuncture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypogonadism
Cardiovascular Outcomes of Low Testosterone
This study plans to learn more about heart and vascular aging in men. In some men as they get older, testosterone levels fall below the normal range for young men. Also, as men get older cardiovascular health worsens.
- Trial name
- CardioVOLT (NCT02758431)
- Testing
- Acyline, Testosterone Gel, Arimidex
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chest Wall and Spinal Disorders
The Pediatric Spine Foundation
The Pediatric Spine Foundation is a registry designed to assist spine surgeons to efficiently identify and track patients with chest wall and spinal disorders.
- Trial name
- NCT02540915
- Testing
- Standard of Care - Registry
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Colorado, Denver
Dysphagia, Aspiration
Aspiration in Acute Respiratory Failure Survivors 2
The purpose of this study is to learn more about problems with swallowing that could develop in patients who are very sick and need a machine to help them breathe.
- Trial name
- NCT05108896
- Testing
- 3-Screenings Protocol, FEES, Tracheal Ultrasound
- Where
- 5 sites in United States
- Volunteers
- 855 people
- Sponsor
- University of Colorado, Denver
Posttraumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Adults With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular aging and autonomic function in adults with nightmares related to PTSD.
- Conditions
- Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT05365607
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infection, Alcohol Abuse
Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease.
- Conditions
- Infection, Alcohol Abuse, Drugs of Abuse, Lung Injury
- Trial name
- NCT02299921
- Testing
- Characterize alcohol and drug use
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Metacarpal Fracture
Intramedullary Fixation for Metacarpal Fractures: A Prospective Study Comparing Outcomes
To prove that use of intramedullary cannulated headless hardware fixation of metacarpal fractures provides anatomic reduction, stable fixation, less operative trauma and early, active post-operative mobilization.
- Trial name
- NCT06631924
- Testing
- Implant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
HIV Prevention, Transgender Women
Long-acting Biomedical HIV Prevention in Transgender Women
Transgender women (TW) have unique challenges related to HIV prevention medication adherence. Left unaddressed, these challenges will prevent TW from accessing the promising long-acting HIV prevention tools in the development…
- Trial name
- NCT03856580
- Testing
- Alternative long-acting PrEP injection strategies, mHealth adherence app
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Burnout, Professional, Self Compassion
Better Together Physician Coaching to Mitigate Burnout Amongst Clinicians
Better Together Physician Coaching ("Better Together", or "BT"), a 4-month, web-based positive psychology multimodal coaching program was built to decrease burnout in medical trainees.
- Conditions
- Burnout, Professional, Self Compassion, Flourishing, Imposter Syndrome
- Trial name
- NCT05635448
- Testing
- Better Together Physician Coaching Program, No intervention - waitlist control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Osteoarthritis, Hip, Osteoarthritis, Knee
Non-invasive Evaluation of Upper and Lower Body Function With Showmotion
It is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury.
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Osteoarthritis, Spine
- Trial name
- NCT04137835
- Testing
- Showmotion
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Burnout, Professional
Better Together Physician Coaching: Mitigating Burnout in UME
Better Together Physician Coaching ("Better Together", or "BT"), a 4-month, web-based positive psychology multimodal coaching program was built to decrease burnout in medical trainees.
- Trial name
- BT for UME (NCT05822375)
- Testing
- Better Together Physician Coaching
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Scoliosis; Adolescence, Degenerative Disc Disease
Personalized Spine Study Group (PSSG) Registry
The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods.
- Conditions
- Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis
- Trial name
- PSSG (NCT04601363)
- Testing
- Patient Specific Rod
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Colorado, Denver
Sleep, Diabetes Mellitus, Type 2
Improving Insulin Resistance and Energy Metabolism Through Sleep Extension in Adolescents
The investigators propose to deliver a 4-week sleep extension intervention to adolescents to evaluate feasibility of the protocol and obtain preliminary data on intra-individual changes in metabolic parameters induced by sleep…
- Trial name
- REM (NCT03814512)
- Testing
- Extended Sleep Intervention
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lumbar Spinal Stenosis
Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine
Evaluate the benefit of using liposomal bupivicaine in lumbar laminectomies in terms of length of stay, IV narcotic use, 30-day narcotic use, visual analog score (VAS) and 30-day readmissions
- Trial name
- NCT04066296
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Literacy, Burden, Caregiver
One-4-ALL Initiative
This study aims to improve health outcomes of individuals and populations, enhance the patient experience, reduce the per capita cost of care, and ensure the well-being of our healthcare providers (quadruple aim).
- Conditions
- Literacy, Burden, Caregiver, Health Care Utilization
- Trial name
- NCT05454969
- Testing
- One-4-ALL Initiative, Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Insulin Sensitivity, Sleep
Impact of Sleep Extension in Adolescents
Many teenagers do not get enough sleep. Obesity and diabetes are increasing in teenagers as well. This study plans to learn more about sleep and insulin resistance (insulin not working) in teenagers, and how these things may be…
- Conditions
- Insulin Sensitivity, Sleep, Dietary Habits
- Trial name
- SUNRISE (NCT03500458)
- Testing
- Sleep Extension
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Stage IV Melanoma, Stage III Melanoma
Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma
This is a Phase I/Ib investigator-initiated open label of the combination of VESANOID and pembrolizumab treatment.
- Conditions
- Stage IV Melanoma, Stage III Melanoma, Advanced Melanoma
- Trial name
- NCT03200847
- Testing
- Pembrolizumab with All-Trans Retinoic Acid
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
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