Clinical trials: sponsored by University of Colorado, Denver
Dietary Habits
Metabolomics Initiative: Mediterranean-amplified vs Habitual Western Diet on Food Signatures, Health, and Microbiome
This study plans to learn more about how consuming a diet with foods typical to a Mediterranean Diet such as whole grains, fruits and vegetables in a Western-style diet compares to eating a typical Western-style diet.
- Trial name
- Mini-MED (NCT05500976)
- Testing
- Semi-controlled dietary intervention - Western, Semi-controlled dietary intervention - MiniMed
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
HPV Infection, Preventive Health Services
PCOM2 - The Physician Communication Intervention, Version 2.0
Poor quality of primary care providers' vaccine recommendations lead to low adolescent human papillomavirus vaccination rates and hundreds of thousands of adolescents unnecessarily at risk for HPV-associated cancers and diseases.
- Trial name
- PCOM2 (NCT05336240)
- Testing
- Physician Communication 2 Virtual (PCOM2-virtual), Physician Communication Standard (PCOM-standard)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Hematopoietic Stem Cell Transplantation
Evaluation of Malglycemia Via Continuous Glucose Monitoring in the Pediatric HSCT Population
This study is designed to determine feasibility of using a continuous glucose monitor in pediatric, adolescent and young adult hematopoietic stem cell transplant (HSCT) recipients, and to identify the incidence and risk factors…
- Trial name
- NCT03037671
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Urticaria, Idiopathic
Molecular Endotypes of Chronic Idiopathic Urticaria
This study plans to learn more about why some people with Chronic Idiopathic Urticaria (CIU) respond to treatment with omalizumab (Xolair).
- Trial name
- NCT04774315
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Shared Decision Making
SHARE Approach Evaluation
The SHARE Approach Evaluation study was meant to evaluate the SHARE Approach, designed by AHRQ and updated by UCD. The SHARE Approach is a training program for clinicians on shared decision making.
- Trial name
- NCT06062940
- Testing
- SHARE Approach
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis Pulmonary Exacerbation
Glucose Monitoring in Youth With Cystic Fibrosis During Pulmonary Exacerbations
The goal of this study is to investigate the prevalence of dysglycemia with continuous glucose monitoring (CGM) obtained during pulmonary exacerbations, both outpatient and inpatient, in youth with cystic fibrosis (CF).
- Trial name
- GeM-PEx (NCT06546943)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Acute Myeloid Leukemia, Relapsed/Refractory Acute Myeloid Leukemia
Arsenic Trioxide With Cyclophosphamide in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Determine the maximum tolerated dose (MTD) and toxicity profile of the combination of cyclophosphamide and ATO (Arsenic Trioxide) in subjects with relapsed refractory AML.
- Trial name
- NCT03318016
- Testing
- Cyclophosphamide 500 MG, Cyclophosphamide 1000 MG, Cyclophosphamide 2000 MG
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Colorado, Denver
Leukemia
Virtual Reality as a Distraction Technique for Performing Lumbar Punctures in Children and Young Adu
The goal of this feasibility study is to determine if Virtual Reality (VR) can be adequately used as an alternative to General Anesthesia (GA) for Lumbar Punctures (LP).
- Trial name
- NCT04092803
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
Cancer Patient Perspectives During COVID-19
A web-based survey will be emailed to all adult women diagnosed with invasive breast cancer or ductal carcinoma in situ who have been seen as surgical consultations within the last year (06/01/19-06/01/20).
- Trial name
- NCT05062538
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease
The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD.
- Trial name
- NCT03582137
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Colorado, Denver
Bronchiolitis
The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study
Over-testing and over-treatment costs the US healthcare system hundreds of billions of dollars a year, and has measurable negative impacts on patients' physical, emotional, and financial health making it a significant public…
- Trial name
- ROUTT-B (NCT04302207)
- Testing
- De-implementation Strategy for Bronchiolitis
- Where
- 3 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Effects of Pecan Nut Snacks v Equicaloric Snacks on Appetite, Food Intake, Metabolism, Hormones and Biomarkers
This is a within-subjects crossover study that examines subjective appetite, food intake, hormone and metabolic responses to consumption of mid morning snacks of pecan nuts as compared to an iso-caloric amount of tortilla chips.
- Trial name
- NCT04484974
- Testing
- Pecan snack, Tortilla chip snack
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)
This study will enroll participants who have been diagnosed with Eosinophilic Esophagitis (EoE). Upon study enrollment, the participant will begin a proton pump inhibitor (PPI), Omeprazole 20mg twice daily.
- Trial name
- NCT04149470
- Testing
- Omeprazole 20mg BID
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Hypospadias, Urethrocutaneous Fistula
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
This is a prospective randomized multi-center non-inferiority trial conducted through the Pediatric Regional Anesthesia Network study sites to determine if caudal block increases the incidence of urethrocutaneous fistula…
- Trial name
- NCT02861950
- Testing
- Caudal block with ropivacaine, penile nerve block with bupivacaine
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of Colorado, Denver
Suicide Prevention
Suicide in Urban Natives: Detection and Networks to Combat Events
This study compares the effectiveness of a program to detect and manage suicide risk among American-Indian and Alaska Native (AI/AN) youth.
- Trial name
- SUNDANCE (NCT03136094)
- Testing
- SBIRT+12, SBIRT+Usual Care
- Where
- United States
- Volunteers
- 698 people
- Sponsor
- University of Colorado, Denver
Alzheimer Disease
Alzheimer's Disease and Precision Medicine Research Among Native People
This project intends to address the gaps in Alzheimer's disease (AD) and precision medicine (PM) research in American Indian and Alaska Native (AI/AN) populations by comparing written and video-based materials for recruitment…
- Trial name
- NCT03448601
- Testing
- Culturally tailored brochure intervention group, Culturally tailored video intervention group
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sexual and Gender Minorities, Hospice
Intervention to Collect and Utilize Sexual Orientation and Gender Identity (SOGI) Information in Hospice
Older sexual and gender minority (SGM) patients are at risk for receiving inequitable end-of-life care; those with Alzheimer's disease and related dementias (ADRD) are at particularly high risk.
- Conditions
- Sexual and Gender Minorities, Hospice, Alzheimer's Disease and Related Dementias
- Trial name
- NCT05877391
- Testing
- SGM Communication Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bacteremia, Sepsis
Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala
The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in…
- Trial name
- NCT05314816
- Testing
- Blood culture identification panel
- Where
- Guatemala
- Volunteers
- 479 people
- Sponsor
- University of Colorado, Denver