Clinical trials: sponsored by University of Colorado, Denver
Menopause, Obesity
Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is…
- Trial name
- NCT02927392
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vitiligo
Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo
This is a phase 2A clinical trial designed to test the pro-melanogenic and anti-inflammatory role of phosphodiesterase-4 inhibitors (PDE4i), alone and in combination with active narrow band UVB (NBUVB), in vitiligo lesions.
- Trial name
- NCT05298033
- Testing
- Crisaborole 2 % Topical Ointment, PF-07038124 0.01% topical ointment, NBUVB phototherapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Solid Tumor, Adult
Cannabis Use in Cancer Patients
The goal of this study is to determine the feasibility of a human observational study of orally administered cannabis use among cancer patients.
- Trial name
- NCT03617692
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
The goal of this clinical trial is to learn if a Decision Aid can help patients with Parkinson's disease make a decision about undergoing Deep Brain Stimulation surgery.
- Trial name
- NCT06446505
- Testing
- Deep Brain Stimulation Decision Aid
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Obesity, Fertility
Dysregulation of FSH in Obesity: Functional and Statistical Analysis
Excess maternal weight, especially obesity, influences almost every aspect of fertility, from conception to problems during pregnancy.
- Trial name
- NCT02478775
- Testing
- Degarelix (GnRH antagonist), recombinant FSH, Cetrorelix
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hepatic Steatosis, Polycystic Ovarian Syndrome
Liver and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance.
- Conditions
- Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
- Trial name
- APPLE (NCT02157974)
- Testing
- Byetta 5Mcg Pen Injection
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Arthroplasties, Knee Replacement
Swelling Management After Knee Replacement
To determine if inelastic adjustable compression garment results in improved surgical limb swelling control (bioimpedance assessment - primary outcome) after TKA compared to control (TED hose).
- Trial name
- NCT06095401
- Testing
- Inelastic adjustable compression garment (INCOM), Elastic compression garment (CONTROL)
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ureteropelvic Junction Obstruction, Ureteropelvic Junction; Obstruction, Congenital
Decision Aid for Parents of Infants With UPJO
Ureteropelvic junction obstruction (UPJO) is the most common etiology of high-grade hydronephrosis, affecting approximately 4,000-10,000 infants annually in the U.S.
- Trial name
- NCT05900375
- Testing
- Parent Decision Aid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Pancreatitis, Chronic
ESWL vs. Pancreatoscopy-guided Lithotripsy for Painful Chronic Calcific Pancreatitis
This is a multi-center randomized controlled trial comparing extracorporeal shock-wave lithotripsy (ESWL) with per-oral pancreatoscopy-guided lithotripsy (PPL) in the treatment of patients with chronic pancreatitis and refractory…
- Trial name
- NCT04115826
- Testing
- Per-oral Pancreatoscopy-guided Lithotripsy, Extracorporeal Shock-Wave Lithotripsy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Chronic Pancreatitis
Quality of Life Assessment of Chronic Pancreatitis Endoscopic Interventions
This study seeks to evaluate the effect of endoscopic interventions on quality of life in patients with chronic pancreatitis. Quality of life will be evaluated using the PANQOLI, a validated quality of life instrument specific to…
- Trial name
- QOLAPI (NCT03632616)
- Testing
- PANQOLI (quality of life instrument)
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Pancreatic Cyst
Evaluation of Pancreatic Cystic Lesions Via EUS-guided Fine Needle Aspiration With and Without Micro Forceps Biopsies
Pancreatic cystic lesions (PCLs) are a common incidental finding in cross sectional imaging (up to 27% on CT scan and 41% on MRI) and pose a management challenge to physicians.
- Trial name
- NCT04404101
- Testing
- 1). EUS-FNA plus MFB, 2). EUS-FNA Alone
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Endoscopic Tissue Apposition, Endoscopic Suturing
Prospective Evaluation of the Efficacy and Safety of Endoscopic Tissue Apposition
This study is a prospective registry of patients undergoing endoscopic suturing and/or clip placement at our institution to assess the efficacy and safety of endoscopic tissue apposition.
- Conditions
- Endoscopic Tissue Apposition, Endoscopic Suturing, Endoscopic Clipping, Bariatric Endoscopy
- Trial name
- NCT03626194
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Inflammatory Bowel Diseases (IBD), Ankylosing Spondylitis (AS)
The Colonic Microbiome and Mucosal Immunity in Inflammatory Bowel Disease and Ankylosing Spondylitis
This study plans to learn more about the relationship between systemic autoimmune disease, such as inflammatory bowel disease and ankylosing spondyloarthritis, bacteria in the colon, and the changes in colon tissue.
- Trial name
- NCT02389075
- Testing
- Pinch biopsies, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Colorado, Denver
Gastrointestinal Neoplasia, Hirschsprung's Disease
Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy
To test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection.
- Conditions
- Gastrointestinal Neoplasia, Hirschsprung's Disease, Esophageal Obstruction, Gastroparesis
- Trial name
- NCT03626350
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Stroke, Acute
The Role of Hyperoxia in Acute Ischemic Stroke
This study is being conducted to evaluate the potential therapeutic role of hyperoxia when applied in the immediate ischemic period following a stroke in the controlled Emergency Department setting.
- Trial name
- NCT03904017
- Testing
- Oxygen
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Epilepsy
A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures
This study is being done to help scientists learn about the use of a device called an atomic magnetometer. The device uses sensors called optically-pumped magnetometers (OPM) which function at room temperature.
- Trial name
- NCT04515316
- Testing
- OPM sensors, SQUID sensors
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Inactivity, Overweight and Obesity
A Pilot Factorial Trial of an Integrated Lifestyle Intervention
This study plans to learn more about the feasibility and acceptability of integrating the Move physical activity support program within an existing lifestyle intervention program.
- Trial name
- NCT06116435
- Testing
- Prevent T2, Move group-based classes, Fitness Membership
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Stimulation of the Rostral Zona Incerta for Parkinson's Disease
Patients with Parkinson's Disease who undergo Deep Brain Stimulation surgery receive symptom relief due to electrical stimulation of the brain. The target for the stimulation, in many cases, is the subthalamic nucleus (STN).
- Trial name
- NCT03212885
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Long COVID
Merging Yoga and Self-Management Skills for Symptoms of Long COVID
Long COVID patients experience high symptom burden for many months after initial infection of the COVID-19 virus. This study will investigate a mobile intervention Merging Yoga and Self-Management Skills (MY-Skills Mobile) as a…
- Trial name
- MYS LCOVID-19 (NCT05697042)
- Testing
- MY-Skills for Long COVID
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
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