Clinical trials: sponsored by University of Colorado, Denver
Frostbite
Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis
This study will compare the effectiveness of two different treatments for preventing infection from frostbite injuries. These two treatments are A) aloe vera and B) long-acting silver wound dressings.
- Trial name
- Frostbite (NCT06266494)
- Testing
- Long-Acting silver dressings, Aloe Vera, Dalbavancin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease, REM Behavior Disorder
Subcortical Oscillations in Human Sleep Dysregulation
Sleep problems are common in the United States (US) adult population (>50 million), and have a negative impact on quality of life, productivity, and healthcare.
- Trial name
- NCT03377569
- Testing
- Sleep, PD and DBS
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Cancer Diagnosis, Couples
Cancer Survivors and Their Romantic Partners' Preferences for a Couples-based Physical Activity
The goal of this research is to explore cancer survivors' and their romantic partners' interest in a couples-based physical activity intervention and whether cancer-specific exercise education influences exercise beliefs and…
- Trial name
- NCT04471363
- Testing
- Cancer-Specific Exercise education
- Where
- United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Klinefelter Syndrome, Trisomy X
The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
This study is designed to research the natural history of neurodevelopment, health and early hormonal function in infants with XXY/Klinefelter syndrome, XYY, XXX and other sex chromosome variations in an effort to identify early…
- Conditions
- Klinefelter Syndrome, Trisomy X, XYY Syndrome, XXXY and XXXXY Syndrome
- Trial name
- NCT03396562
- Testing
- Assessments of Development and Growth
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Peritonitis, Peritonitis Bacterial
Evaluation of Intravenous Dalbavancin for Peritonitis
This study evaluates the use of Dalbavancin 1500 mg IV x 1 dose for treating patients with gram positive peritonitis in patients requiring peritoneal dialysis.
- Trial name
- NCT04624451
- Testing
- Dalbavancin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Colorado, Denver
Hospice Care, Decision Aid
Underutilization of Hospice Care in Older Black Adults
This study will sample older Black adults to test their knowledge and opinions of hospice.
- Conditions
- Hospice Care, Decision Aid, Decision-Making, Aging
- Trial name
- NCT06408090
- Testing
- IDECIDE-HOSPICE
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder
CASCADE: CAnnabidiol Study in Children With Autism Spectrum DisordEr
This is a randomized, placebo-controlled study but all study participants will receive the active study medication at some point during the study for at least 12 weeks, and some children with receive CBD for the entire study.
- Trial name
- CASCADE (NCT04520685)
- Testing
- Oral cannabidiol 100mg/mL
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Colorado, Denver
Racially/Ethnically Diverse Families From Urban Settings
Multi-level Predictors of Structural Racism and Discrimination and Associations With Health and Well-being Across the Life Course in Diverse Families
Minoritized populations face mutually reinforcing levels of structural disadvantage that contribute to poor health. Despite recognition that social and economic stratification, environmental conditions, and policy are critical…
- Trial name
- NCT05744973
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 631 people
- Sponsor
- University of Colorado, Denver
Hiv
TelePrEP for At-risk Youth in Colorado
Youth represent the largest proportion of new HIV infections in Colorado, reflective of their inadequate access and uptake of pre-exposure prophylaxis(PrEP)for HIV prevention.
- Trial name
- NCT05520905
- Testing
- TelePrEP
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy
Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Patients with biochemically confirmed SLOS are being treated with cholesterol supplementation and antioxidant medication. They are carefully monitored with visits to clinic, laboratory testing including cholesterol and…
- Conditions
- Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy, Hearing Loss
- Trial name
- NCT01773278
- Testing
- Antioxidants, Cholesterol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Transgenderism, Kidney Diseases
Effect of Hormone Therapy on Renal Function
The purpose of this study is to understand the effects of testosterone or estradiol on kidney function in transgender adolescents and young adults.
- Conditions
- Transgenderism, Kidney Diseases, Kidney Injury
- Trial name
- NCT04482920
- Testing
- p-aminohippurate clearance study, Iohexol infusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
Rheumatoid Arthritis, Interstitial Lung Disease
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression.
- Trial name
- MOUNTAIN (NCT06397677)
- Testing
- Research Testing Performed (Laboratory), Information Collected as Standard of Care, Research Testing Performed
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Colorado, Denver
High Risk Acute Lymphoblastic Leukemia
HCL Single Arm Pilot Study in Treatment of Hyperglycemia of Pediatric ALL
The overall objective of this pilot study is to determine the safety and feasibility of a hybrid closed-loop insulin delivery system for children and young adults with high risk acute lymphoblastic leukemia, during the induction…
- Trial name
- NCT05006040
- Testing
- Hybrid Closed Loop System
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1.
- Trial name
- NCT03014401
- Testing
- Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Degenerative Lesion of Articular Cartilage of Knee
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the…
- Trial name
- NCT02090140
- Testing
- ADSC Application, Microfracture
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Irritable Mood, Mood Disorders
Hostile Interpretation Bias Training to Treat Irritability
Hostile interpretation bias may be a feature of severe, chronic irritability in children, one of the most common psychiatric symptoms of childhood.
- Trial name
- NCT03592368
- Testing
- IBT
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Colorado, Denver
Sex Chromosome Aneuploidy
Generating Advancements Through Longitudinal Analysis in X and Y Variations (GALAXY)
GALAXY is a registry research study that plans to learn more about individuals with X\&Y variations (also called sex chromosome aneuploidies) through collecting information from medical records.This includes genetic tests…
- Trial name
- GALAXY (NCT06373861)
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovarian Syndrome, Obesity
Post-Prandial Liver Glucose Metabolism in PCOS
The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- PLUM (NCT03041129)
- Testing
- oral glucose tolerance test, MRI of liver
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Melanoma
Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma
The goal of this proposal is to determine how cannabinoid use affects the tumor immune microenvironment (TME) of melanoma by correlating TILs with reported cannabinoid use and circulating plasma cannabinoids.
- Trial name
- NCT05520294
- Testing
- High-performance liquid chromatography-tandem mass spectrometry assays
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Smoking Cessation
Designing an Implementation Strategy for Lung Screening and Smoking Cessation Treatment in Community Health Centers
Tobacco use is the leading preventable cause of death in the US and a major driver of health disparities. Among our tools for reducing the harms of tobacco is lung cancer screening (LCS).
- Trial name
- SAILS-FQHC (NCT05447897)
- Testing
- Qualitative Group Interviews, Stakeholder advisory group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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