Clinical trials: sponsored by University of Colorado, Denver
Depression, Anxiety, Self Efficacy
Advocates for All Youth
Advocates for ALLY Youth (ALLY) is a universal, school-based, multicomponent positive psychology program aimed to increase youth's well-being and reduce symptoms of psychological distress including depression, anxiety, and stress.
- Conditions
- Depression, Anxiety, Self Efficacy, Suicidal Ideation
- Trial name
- ALLY (NCT05025657)
- Testing
- ALLY
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Periodontitis, Calculus, Dental
Accuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss
To compare the diagnostic accuracy of extra-oral x-rays with intra-oral x-rays, in contrast to clinically observed measurements, for the detection of calculus and bone loss of either the suprabony or infrabony types in patients…
- Conditions
- Periodontitis, Calculus, Dental, Bone Loss, Alveolar
- Trial name
- NCT05887128
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Human Energy Expenditure
Validation of a Portable Indirect Calorimeter
This study plans to test the accuracy of a new device (the Apollo EE Device) that measures resting energy expenditure (REE) using only oxygen consumed (VO2).
- Trial name
- NCT04469452
- Testing
- Apollo Device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lupus Erythematosus, Rheumatoid Arthritis
Analysis of B Cells From Autoimmune Individuals
This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells of individuals genetically susceptible…
- Conditions
- Lupus Erythematosus, Rheumatoid Arthritis, Type 1 Diabetes
- Trial name
- NCT02747277
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Colorectal Polyp, Colonic Neoplasms
Online Education Module to Accurately Classify Polyp Size
Investigators developed an online educational module (ESTIMATE) to teach Gastroenterology (GI) trainees how to estimate polyp size using a snare.
- Trial name
- ESTIMATE (NCT05846295)
- Testing
- ESTIMATE
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Colorado, Denver
Cognitive Impairment
Group Interval Fitness Program for Adolescents With Cognitive Impairments in the School Setting.
This study examines the outcomes of a group interval fitness program for secondary students with cognitive impairments in the school setting.
- Trial name
- NCT06061900
- Testing
- Group exercise program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
Tissue-specific Effects of Insufficient Sleep
This study plans to learn more about how sleep loss impacts the way the body responds to sugar. This work will have important implications for development of treatments and countermeasures for people who are not able to get…
- Trial name
- NCT03437681
- Testing
- Insufficient sleep
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HIV/AIDS
Rapid Start vs. Standard Start Antiretroviral Therapy (ART) in HIV
This study plans to learn about whether starting HIV treatment very soon after diagnosis is more beneficial than waiting until entering routine clinical care after diagnosis.
- Trial name
- B-HASTE (NCT04249037)
- Testing
- bictegravir/emtricitabine/tenofovir alafenamide (BIC/F/TAF), Standard initiation of antiretroviral therapy (ART)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Preclinical Imaging Biomarkers of Alzheimer's Disease Neuropathology in Young Adults With Youth-onset Diabetes: a Proof-of-concept Study
The goal of the study is to characterize preclinical Alzheimer's Disease and related dementias (AD/ADRD) neuropathology in a selected group of young adults with youth-onset diabetes, and an age-similar group of young adults…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes, Youth Onset
- Trial name
- NCT05350514
- Testing
- PI-2620 tracer
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postpartum Depression
Parenting Skills Group for Mothers With Postpartum Depression
The goal of this longitudinal study is to study the effects of a parenting skills group (Circle of Security Parenting, aka COSP) in mothers with postpartum depression.
- Trial name
- NCT05772897
- Testing
- Circle of Security Parenting program
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Idiopathic Dilated Cardiomyopathy
Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart
The primary goal of the study is to measure in the intact human heart, the alterations in gene expression over time that are associated with reverse remodeling in response to β-blockade.
- Trial name
- BORG (NCT01798992)
- Testing
- Carvedilol, Metoprolol succinate, Metoprolol succinate + doxazosin
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Colorado, Denver
Pregnancy Related, COVID
In-Utero Vascular Accidents in Neonates From COVID-19 Infected Mothers
The pregnancy related pro-thrombotic state, in addition to the COVID-19 associated hypercoagulability may have unknown consequences to the developing fetus.
- Conditions
- Pregnancy Related, COVID, Intestinal Atresia, Limb Anomaly
- Trial name
- NCT04431869
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus, Pregnancy in Diabetes
Pregnancy Intervention With a Closed-Loop System (PICLS) Study
In pregnancies associated with diabetes, lowering glucose to the recommended targets to prevent adverse health outcomes often leads to significant hypoglycemia.
- Trial name
- PICLS (NCT03774186)
- Testing
- Hybrid closed-loop therapy, Sensor-augmented pump therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness
The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness
Acute Mountain Sickness (AMS) is a common condition affecting individuals traveling to elevations greater than 2500 meters (8200 feet).
- Trial name
- NCT06145113
- Testing
- Continuous positive airway pressure (CPAP), ResMed AirMini
- Where
- Nepal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Pregnancy in Diabetic
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
This research study is called 'PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life: The PROMISE Study'.
- Trial name
- PROMISE (NCT06141434)
- Where
- 4 sites in United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vulvar Intraepithelial Neoplasia (VIN)
Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia
The primary objective of this study is to evaluate the incidence of vulva dysplasia recurrence within 12 months of treatment with Carbon Dioxide (CO2) laser ablation or ultrasonic aspiration.
- Trial name
- NCT02875561
- Testing
- Sonopet Ultrasonic Aspirator, CO2 Laser Ablation
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Heart Diseases, Left Ventricular Dysfunction
InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's
The primary reason the investigators are doing this study are to understand how the right side of the heart functions in heart failure patients with left ventricular assist devices (LVADs, or "mechanical hearts").
- Trial name
- ROBIN (NCT03232736)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breast Cancer
Tucatinib, Palbociclib and Letrozole in Metastatic Hormone Receptor Positive and HER2-positive Breast Cancer
This is a multicenter run-in phase Ib / roll-over phase II study of triple targeted drug combination (HER2-targeted small molecule inhibitor tucatinib, CDK4/6 inhibitor palbociclib and aromatase inhibitor letrozole) as a first or…
- Trial name
- NCT03054363
- Testing
- Tucatinib in Combination with Palbociclib and Letrozole
- Where
- 6 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Prostate Cancer, Prostate Adenocarcinoma
68Ga-PSMA-11 PET in Patients With Prostate Cancer
Patients will receive a single dose of 68Ga-PSMA-11 and undergo a PET/CT or PET/MRI imaging study.
- Trial name
- NCT05197257
- Testing
- Ga-PSMA-11
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- University of Colorado, Denver
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