Clinical trials: sponsored by University of Colorado, Denver
Qualitative Research, Beliefs
A Qualitative Study of Cultural Perception of Health in Rural Guatemala
The Investigators will be giving a survey to ~100 people in a rural community in Guatemala to discover beliefs and perspectives that the Participants have surrounding various aspects of healthcare.
- Trial name
- deCiPHeRGap (NCT04149236)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis
Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS)
Natural history research in Multiple Sclerosis (MS) suggests that risk of relapses and new Magnetic Resonance Imaging (MRI) changes diminish significantly as people age, especially in MS patients 55 or older.
- Trial name
- DISCOMS (NCT03073603)
- Testing
- Discontinuation of disease modifying therapy, Standard of Care
- Where
- 19 sites in United States
- Volunteers
- 259 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Obesity
Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study
Type 2 diabetes (T2D) in youth is increasing in prevalence in parallel with the obesity epidemic. In the US, almost half of patients with renal failure have DKD, and ≥80% have T2D.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Nephropathy, Adolescent Obesity
- Trial name
- Renal-HEIR (NCT03584217)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Renal Biopsy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Household Air Pollution, Behavior, Social
P3 Ghana Cookstove Study
Background: Despite their potential health and social benefits, adoption and use of improved cookstoves has been low throughout much of the world.
- Trial name
- P3 (NCT03617952)
- Testing
- P3 Bio Intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Individuals, Hearing Loss, Central
The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss
Age-related hearing loss, presbycusis, affects up to 50% of American adults. There are two main causes for presbycusis: 1) Progressive death of hair cells in the inner ear, and 2) Central hearing loss, or the reduced ability to…
- Trial name
- NCT04513782
- Testing
- Audiological Assessments
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea, Squamous Cell Carcinoma of Head and Neck
Sleep Apnea in Head and Neck Cancer Patients at the University of Colorado
Obstructive sleep apnea (OSA) is increasingly recognized in patients with squamous cell carcinoma of the head and neck (SCCHN). The prevalence prior and after cancer therapy is not well understood.
- Trial name
- OSA-HN (NCT04922112)
- Testing
- Obstructive sleep apnea testing
- Where
- United States
- Sponsor
- University of Colorado, Denver
Hypoxemia, Altitude Hypoxia
Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude
Dyspnea and exercise intolerance are well known to travelers who have experienced time at high elevations, greater than 2500 meters (8200 feet).
- Trial name
- NCT05971290
- Testing
- Continuous positive airway pressure, Ambient air
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep
Sleep, Insulin Sensitivity, and Weight in Adolescents Post-bariatric Surgery
Assessing sleep and circadian health in severely obese adolescents undergoing bariatric surgery and examine relation to health outcomes including insulin sensitivity and percent weight loss to date at 1-year and evaluate the…
- Trial name
- NCT04202731
- Testing
- PBS Study
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Kidney Disease, Metabolic Acidosis
Bicarbonate Administration in CKD
Low serum bicarbonate levels, even within the normal laboratory range, are strongly associated with increased risks of hypertension, endothelial dysfunction, cardiovascular disease and death.
- Trial name
- NCT02915601
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes
This study will evaluate the effects of impaired blood flow regulation on exercise. It will also determine whether the effects are more important in the heart or in the skeletal muscle tissue during exercise.
- Trial name
- InsITE (NCT00786019)
- Testing
- Exercise program, Ascorbic Acid (Vitamin C)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Impact of Exenatide on Cardiovascular Exercise Performance in Type 2 Diabetes
Previous research in our lab and others has established that type 2 diabetes (T2D) is associated with significantly impaired functional exercise capacity, a factor which is potentially associated with an increased risk of…
- Trial name
- Exenatide (NCT01364584)
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Type 2 Diabetes and Exercise Function in Single Leg Exercises
This study plans to learn more about the effects of type 2 diabetes (T2DM) on exercise blood flow and muscle oxygen uptake. This study will evaluate \& compare exercise function during single leg plantar flexion exercise in a…
- Trial name
- NCT01793909
- Testing
- Single Leg Exercise Training
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Cardiovascular Disease
Impact of Sitagliptin on Cardiovascular Exercise Performance in Type 2 Diabetes
The goal of this study is to examine whether sitagliptin, an agent which enhances the action of hormones that control the release of insulin and is already in clinical use for type 2 diabetes, might also improve functional…
- Trial name
- NCT01951339
- Testing
- Sitagliptin, Glimepiride
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Healthy
Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex
This study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women with and without type 2 diabetes (T2DM).
- Conditions
- Type 2 Diabetes Mellitus, Healthy, Overweight, Cardiovascular Risk Factor
- Trial name
- NCT03419195
- Testing
- Cardiovascular exercise training
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypovolemia, Craniosynostoses
Bedside Resources to Gauge Intravascular Volume Status
The goal if this study is to employ the CardioQ-Esophageal Aortic Doppler probe to define fluid responders from non-responders among infants undergoing cranial vault reconstruction for craniosynostosis.
- Trial name
- NCT03915587
- Testing
- CardioQ-EDM and CipherOx-CRI
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
HIV-1-infection, Weight Gain
Explorations Into the Mechanism for INSTI-associated Weight Gain: a Focus on Energy Balance
Weight gain following antiretroviral therapy (ART) initiation occurs with all modern regimens. Recent real-world reports suggest that integrase strand transfer inhibitor (INSTI)-based ART may be associated with excess weight gain…
- Trial name
- NCT04495348
- Testing
- Doravirine
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Chronic Conditions, Multiple
Social Convoy Palliative Care (Convoy-Pal) Mobile Health for Older Adults
The aim of this study is to test the feasibility and usability of the Convoy-Pal mobile intervention among older adults. The study is a pilot waitlist control RCT with 40 patients and their convoys randomized to one of two arms…
- Trial name
- ConvoyPal (NCT04779931)
- Testing
- Convoy-Pal
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Pain, Musculoskeletal Pain
Topical Cannabis for Chronic Musculoskeletal Pain
Our proposal objective is to evaluate if state-regulated topical CBD-based products relieve chronic musculoskeletal pain and/or absorb into the bloodstream.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Joint Pain
- Trial name
- NCT05908552
- Volunteers
- 77 people
- Sponsor
- University of Colorado, Denver
Central Venous Catheter Exit Site Infection, Central Venous Catheter Related Bloodstream Infection
A New Securement Method for External Tunneled Central Venous Access Devices (CVAD)
An external tunneled central venous access device (CVAD) is a small plastic tube that is tunneled under the skin into a major vein for long-term use (Figure 1).
- Trial name
- NCT04462861
- Testing
- Central venous access device (CVAD) Snuggie Securement Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Obesity
Nicotinic Agonist Effects on BMI and Neuronal Response
Obesity is a serious and growing health problem in the United States. Obesity is associated with health problems such as type-2 diabetes and cardiovascular disease, leading to decreased quality of life and increased mortality.
- Trial name
- NCT02458313
- Testing
- DMXB-A
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.