Clinical trials: sponsored by University of Colorado, Denver
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Contraception
Shoulder Contraceptive Implant Study
This study will be the first to establish pharmacokinetic curves for the etonogestrel contraceptive implant with scapular subdermal insertion.
- Trial name
- NCT04463693
- Testing
- Etonogestrel implant
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postsurgical Hypothyroidism, Hypothyroidism
Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?
Patients taking thyroid hormone replacement after thyroid removal surgery often report feeling differently than they did prior to taking thyroid hormone.
- Trial name
- NCT02567877
- Testing
- thyroidectomy, levothyroxine in thyroidectomy patients
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Epilepsy
Assessment of Effect of Vagal Nerve Stimulator (VNS) on Electrocorticograms Recorded by Responsive Neurostimulator (RNS) in Patients With Drug Resistant Epilepsy
This study will investigate whether a Vagal Nerve Stimulator (VNS) causes measurable desynchronization and reduces epileptiform activity, such as spikes and seizures, in electrocorticograms (ECOGs) recorded by a Responsive…
- Trial name
- NCT03595072
- Testing
- observation of VNS stimulation effects
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure, Systolic, Mechanical Circulatory Support
Cardiac Output in Heart Failure Patients With Mechanical Pumps
This study will be looking at how cardiovascular hemodynamics, including cardiac output and flow through a left ventricular assist device (LVADs), change in response to alterations in preload, afterload, and contractility, and…
- Conditions
- Heart Failure, Systolic, Mechanical Circulatory Support, Cardiovascular Hemodynamics
- Trial name
- NCT05195931
- Testing
- preload challenge, afterload challenge, contractility assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Heart Failure, Athletes Heart
Cardiopulmonary and Right Ventricular Function in Health and Disease
The primary objective of this research protocol is to advance the understanding of cardiopulmonary and right ventricular (RV) performance among individuals with cardiomyopathy (heart failure with reduced ejection fraction…
- Trial name
- NCT04147299
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Heart Failure，Congestive
Effect of mechanIcal circulatoRy Support ON Exercise Capacity aMong pAtieNts With Heart Failure
This study will evaluate how the cardiovascular system interacts with mechanical hearts to provide blood flow to the body during exercise.
- Trial name
- IRONMAN (NCT03078972)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non Small Cell Lung Cancer, CNS Progression
Temodar Plus Tyrosine Kinase Inhibitors for Progressive CNS Disease
This trial is testing two novel combinations (temozolomide plus osimertinib OR temozolomide plus lorlatinib) which have not been evaluated in clinical trials. Thus, the exact benefits of these novel combinations are unclear.
- Trial name
- NCT04541407
- Testing
- Temozolomide plus Osimertinib, Temozolomide plus Lorlatinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Contraception, Tuberculosis
Rifampin and the Contraceptive Implant
It is important for women taking rifampin to be aware if they are at greater risk of an unintended pregnancy while on the implant. An unintended pregnancy has many social, emotional, and financial impacts on women and society.
- Trial name
- NCT04463680
- Testing
- Rifampin 600 MG
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Maternal Immunization
Adapting Motivational Interviewing for Maternal Immunizations (MI4MI)
Vaccinating pregnant women affords a unique opportunity to protect both mother and child against influenza and pertussis, yet uptake of maternal immunizations remain far below national target goals.
- Trial name
- MI4MI (NCT04302675)
- Testing
- Prevention, Maternal Immunization
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Transplantation, Chronic Renal Insufficiency
Genetic Predictors of Renal Dysfunction Following Heart Transplantation
Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus.
- Trial name
- NCT01686191
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Visual Snow Syndrome
Transcranial Magnetic Stimulation For Visual Snow Syndrome
This study aims to investigate the feasibility of the use of repetitive transcranial magnetic stimulation (rTMS) for symptoms associated with Visual Snow syndrome (VS).
- Trial name
- TMSVS (NCT04925232)
- Testing
- Transcranial Magnetic Stimulation device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Blood Transfusion
Blood Transfusion Reduction - QI Project
Blood Banks of large medical centers have large annual budgets, typically millions of dollars. Blood product wastage results in not only in a loss of the product's cost, but also of the fees involved in transporting, handling…
- Trial name
- NCT04823273
- Testing
- General improvement, In-line help text, Interruptive alert
- Where
- United States
- Volunteers
- 1,640 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Congenital Heart Disease, Edema
Point of Care Ultrasound Measurements of Perioperative Edema in Infants With Congenital Heart Disease
Babies can be born with heart problems and sometimes need a heart surgery to fix the heart problem. Heart surgery can cause swelling from the build-up of extra fluid.
- Conditions
- Congenital Heart Disease, Edema, Fluid Overload
- Trial name
- NCT04151160
- Testing
- Point of care ultrasound measurements
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension;Pulmonary;Primary
Observational Study of Actigraphy in Pediatric Pulmonary Arterial Hypertension
This study plans to learn more about activity levels in children with pulmonary hypertension. Pulmonary hypertension is a condition where the pressure in the lungs is higher than normal. This can affect the person's heart.
- Trial name
- NCT04745000
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Feeding Behavior
Healthy Starts: Repeated Exposure Pilot
Decades of research have established that providing repeated exposure to new foods is the most robust strategy for promoting children's acceptance of new foods (1).
- Trial name
- NCT05639361
- Testing
- Repeated Exposure
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ventricular Dysfunction, Right, Hypoxia
Impact of Hypoxia on Resting and Exertional Right Ventricular Performance
The purpose of this study is to better understand how hypoxia (low oxygen) affects resting and exertional right ventricular function in healthy individuals.
- Trial name
- NCT05272514
- Testing
- Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Evaluating Adrenal Insufficiency in Adults With Eosinophilic Esophagitis on Chronic Swallowed Topical Steroids
Eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus, is a clinical and financial burden to patients if left untreated.
- Trial name
- NCT05246085
- Testing
- Cortisol level
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis
A Trial of Neuroprotection With ACTH in Acute Optic Neuritis
We hypothesize that the novel melanocortin-mediated anti-inflammatory effects of ACTH will reduce axonal loss following ON by limiting inflammatory optic nerve injury.
- Trial name
- ACTHAR (NCT01838174)
- Testing
- ACTHAR Gel (ACTH), IV methylprednisolone (steroids)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Colorado, Denver
Chronic Exertional Compartment Syndrome
Utilization of High Frequency Ultrasound to Diagnose Chronic Exertional Compartment Syndrome
The purpose of this study is to investigate high frequency ultrasound as a future modality for the diagnosis of chronic exertional compartment syndrome (CECS).
- Trial name
- NCT03736174
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
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