Clinical trials: sponsored by University of Colorado, Denver
Linezolid Pharmacokinetics in Young Infants, Pharmacokinetic Analysis
Oral Antibiotic Pharmacokinetics in Young Infants
This observational study will characterize the pharmacokinetics of linezolid in young infants. Participants will receive linezolid either as part of routine clinical care or as a single, one-time study dose.
- Conditions
- Linezolid Pharmacokinetics in Young Infants, Pharmacokinetic Analysis, Linezolid, Infant and Young Children
- Trial name
- NCT07815613
- Testing
- Linezolid (LZD)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology
The primary objective of the study is to determine whether dietary intervention to increase fiber and decrease fat reduces C. difficile infection recurrence in a cohort of oncology patients.
- Conditions
- Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute, Lymphoma, Clostridium Difficile Infection
- Trial name
- NCT04940468
- Testing
- Diet Intervention
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Gut Microbiome, Linear Growth
Effects of Complementary Feeding on Infant Growth and Gut Health
This study plans to learn more about how consuming different foods during the time of early complementary feeding (~5 to 12 months) affects growth and the development of bacteria living inside your baby's gut through school-age.
- Trial name
- MINT (NCT05012930)
- Testing
- Baby Foods - Meat, Baby Foods - Dairy, Baby Foods - Plant
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Survivors of Childhood Cancer, Bladder Dysfunction
Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.
- Trial name
- NCT04993859
- Testing
- Non-invasive Urodynamic Test (niUDS), Urinary proteomic screen, Dysfunctional Voiding Symptom Score Survey (DVSS)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Colorado, Denver
Breast Cancer, Ovarian Cancer
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence
The goal of this clinical trial is to test whether psilocybin along with therapy in women with early breast cancer and ovarian cancer in remission can improve their fear of recurrence.
- Trial name
- NCT06430541
- Testing
- Psilocybin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Overweight and Obese Adults
Behavioral Weight Loss and Sleep Health Intervention
This is a 6-month single-arm pilot and feasibility study designed to examine if a behavioral weight loss (BWL) intervention with an added sleep health program (BWL+SLEEP) can achieve clinically meaningful weight loss and…
- Trial name
- DREAM (NCT07255287)
- Testing
- BWL+Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Bile Duct Adenocarcinoma, Bile Duct Carcinoma
Study of Large Channel Digital Pancreaticobiliary Scope (DPS) With Compatible Accessories
This study plans to enroll up to 75 research subject who have a biliary disorder such as bile duct stones or intermediate biliary strictures.
- Trial name
- NCT07120295
- Testing
- Dragonfly™ Digital Pancreaticobiliary System
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Cancer Survivorship, Overweight , Obesity
BfedBwell INSPIRE Pilot
This single-arm pilot study will evaluate the feasibility and acceptability of a comprehensive survivorship lifestyle intervention addressing nutrition, exercise, sleep health, and stress management.
- Trial name
- NCT07446595
- Testing
- BfedBwell - Core Curriculum, BfedBwell - 1:1 Counseling, BfedBwell - Behavioral Skills
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Down Syndrome, Regression
Therapies for Down Syndrome Regression Disorder
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD).
- Trial name
- NCT05662228
- Testing
- Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Down Syndrome
Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1
This protocol describes a phase 2, double-blind, randomized, placebo-controlled clinical trial for Janus kinase (JAK) inhibition in Down syndrome (DS).
- Trial name
- MISSION-1 (NCT07598643)
- Testing
- Tofacitinib Oral Solution
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Denver
Spina Bifida, Fecal Incontinence
Enema Device for Children With Spina Bifida
The International Center for Colorectal and Urogenital Care at Children's Hospital Colorado treats patients who suffer from many different colorectal issues such as anorectal malformation, Hirschsprung disease, and severe…
- Trial name
- NCT05253196
- Testing
- Use of the foley catheter assistive device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Microsatellite Stable Metastatic Colorectal Cancer
Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer
This Phase 2 clinical study will evaluate evorpacept (ALX148) in combination with cetuximab and pembrolizumab for refractory microsatellite stable metastatic colorectal cancer
- Trial name
- NCT05167409
- Testing
- Evorpacept (ALX148), Cetuximab, Pembrolizumab
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
A Novel Patient Decision Aid for Surgical Treatment Options in Early-Stage Breast Cancer
This is a study to assess the feasibility and acceptability of a novel decision aid (DA) in a newly diagnosed, early-stage breast cancer population.
- Trial name
- NCT06813053
- Testing
- Decision Aid (DA), Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Heart Failure, Caregiver Burden
Digital Health Physical Activity Program for Older Family Care Partners of Patents With Heart Failure
The purpose of the Aim 3 study is to conduct a pilot randomized controlled trial to assess feasibility and preliminary effects of the TPA4You intervention.
- Trial name
- NCT05852509
- Testing
- TPA4You, Attention control group
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Rectal Adenocarcinoma, Rectal Cancer
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
Rectal cancer patients who do not achieve a complete response to standard of care chemotherapy and radiation often require surgical resection as part of curative intent therapy.
- Trial name
- NCT07292298
- Testing
- High Rare Dose Rectal Brachytherapy Boost
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Colorado, Denver
Androgen Deprivation Therapy, Prostate Cancer
Contributions to Hypertension With Androgen Deprivation Therapy
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer.
- Conditions
- Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction
- Trial name
- ARCH (NCT05700903)
- Testing
- Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Malignant Melanoma
Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma
Activation of the RIG-I innate immune pathway and increased expression of tumor antigens and pro-immune genes by DEC-C during Nivolumab treatment may enhance the frequency and activity of anti-tumor immune cells (CD4+ and CD8+…
- Trial name
- NCT05089370
- Testing
- Oral Decitabine/Cedazuridine (DEC-C) in Combination with Nivolumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Osteosarcoma
Losartan + Sunitinib in Treatment of Osteosarcoma
This study is a Phase 1/1b clinical trial that aims to determine the Maximally Tolerated Dose of Losartan and Sunitinib Combination Therapy.
- Trial name
- NCT03900793
- Testing
- Losartan, Sunitinib
- Where
- 4 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
4:3 Intermittent Fasting Intervention in Adults With Breast Cancer and Overweight or Obesity
This is a 3 month single arm pilot and feasibility study designed to examine the impact of an intermittent fasting lifestyle weight loss intervention on pre-specified clinical milestones (change in body weight, adherence to the…
- Trial name
- NCT06399276
- Testing
- Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Concussion, Brain, Treatment
Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects…
- Conditions
- Concussion, Brain, Treatment, Aerobic Exercise, Inflammation
- Trial name
- MEDIC (NCT05434130)
- Testing
- High Dose Exercise
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Colorado, Denver
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