Clinical trials: sponsored by University of Colorado, Denver
Colorectal Disorders, Surgery
Transverse Abdominus Plane Block Study
Study the effect of laparoscopic guided TAP block on opioid consumption and associated costs using a mixture of dexmedetomidine, dexamethasone, and ropivacaine versus Liposomal bupivacaine (Exparel®) in patients who undergo…
- Trial name
- TAP (NCT05216055)
- Testing
- Ropivacaine, Dexmedetomidine, Dexamethasone sodium phosphate, Normal saline, Liposomal bupivacaine
- Sponsor
- University of Colorado, Denver
Neurologic Disorder, Chronic Disease
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
This study plans to learn about how to measure symptoms (like tiredness or rash) in children with special healthcare needs who take 5 or more medications. Sometimes symptoms change in severity over time or new symptoms develop.
- Conditions
- Neurologic Disorder, Chronic Disease, Pediatric Disorder
- Trial name
- PRSA (NCT03849066)
- Testing
- Parent-Reported Symptom Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Colorado, Denver
Cardiac Arrest With Successful Resuscitation
A Novel Patient Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
This study will test the feasibility and acceptability of deploying a decision aid for surrogate decision makers of comatose survivors of cardiac arrest early during hospitalization.
- Trial name
- NCT03908346
- Testing
- Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
AKI, Sepsis
Effect of CRRT Duration on Solute Removal
The only FDA approved treatment for acute kidney injury(AKI) for patients is Dialysis-also known as renal replacement therapy(RRT). Continuous RRT(CRRT) is the preferred method in the ICU.
- Trial name
- NCT04458571
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury, Immune Deficiency
Immunoparalysis in Acute Kidney Injury After Cardiac Surgery
Infection and sepsis are common after acute kidney injury (AKI) and increase mortality. In this study, the investigators will determine whether patients with acute kidney injury after cardiac surgery have immunosuppression as…
- Trial name
- NCT03922958
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Diabetic Kidney Disease, Type 1 Diabetes
Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance
Type 1 diabetes (T1D) is a complex metabolic disorder with many pathophysiological disturbances including insulin resistance (IR) and mitochondrial dysfunction which are causally related to the development of diabetic kidney…
- Conditions
- Diabetic Kidney Disease, Type 1 Diabetes, Diabetes, Diabetes Mellitus
- Trial name
- CROCODILE (NCT04074668)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 milligrams/milliliter (mg/ml), PET/CT Scan
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hip Arthroscopy
Modifications of Devices for Hip Arthroscopy
This is protocol is intended to demonstrate the principal investigator's improvements and modifications of a hip capsule side fixed slotted cannula for continued access to the hip joint and a bone graft delivery tool set for…
- Trial name
- NCT04516109
- Testing
- Modified hip capsule side fixed slotted cannula, Modified bone graft delivery tool set
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis, Magnetic Resonance Imaging
Risk Factors in Early Multiple Sclerosis
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk…
- Conditions
- Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome
- Trial name
- RISEMS (NCT03586986)
- Testing
- Brain MRI
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Polycystic Kidney Disease, Adult, Polycystic Kidney, Autosomal Dominant
PErfusioN, OxyGen ConsUmptIon and ENergetics in ADPKD (PENGUIN)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage kidney disease (ESKD). The disorder is characterized by development and continued growth of multiple cysts requiring renal…
- Trial name
- PENGUIN (NCT04407481)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 milligrams per milliliter (MG/ML), PET/CT Scan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
Infant Development
Early Iron Exposure on the Gut Microbiota in Young Infants
This study will look at the amount of iron in infant formula and how that affects a child's gut development. The children of mothers who plan to formula feed their children will be randomized to receive either high iron or low…
- Trial name
- IF (NCT03828708)
- Testing
- Iron in infant formula
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Linear Growth, Neurodevelopment
The Effects of Early Complementary Feeding on Growth, Neurodevelopment, Sleep and Gut Health
The overall objective of this project is to understand how consuming a prescribed diet of different infant foods (which may contain cereals,fruits, vegetables, meats, dairy) during the time of early complementary feeding (~5 to…
- Conditions
- Linear Growth, Neurodevelopment, Gut Microbiome
- Trial name
- NCT04137445
- Testing
- Baby Foods, Foods from the home
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Asthma, Obesity
Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics
The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology.
- Conditions
- Asthma, Obesity, Metabolic Syndrome
- Trial name
- NCT03215836
- Testing
- Bronchoscopy and Nasal Epithelium Brush Sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Using Parkinson's Disease to Study the Role of the Substantia Nigra Pars Reticulata
Parkinson's Disease (PD) is a movement disorder causing either uncontrolled movement, slowness of movement, slowness of initiation of movement or rigidity of muscles.
- Trial name
- NCT02216435
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Colorado, Denver
Tobacco Use Cessation, Second Hand Tobacco Smoke
Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)
Children who are hospitalized are especially vulnerable to the effects of tobacco use and dependence among their caregivers, and they are more likely to be exposed than children who are not hospitalized.
- Trial name
- INSPIRE (NCT02281864)
- Testing
- Smoking Cessation Intervention Bundle, Control Group: Quitline
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Colorado, Denver
Hypertension
The Multicenter Randomized HYpertension and VALUEs (HYVALUE) Trial
The objective of this study is to reduce the effects of stereotype threat on the adherence of African American patients with hypertension.
- Trial name
- HYVALUE (NCT03028597)
- Testing
- Intervention Values Affirmation, Control Values Affirmation
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Alcohol, Inflammation, and Mindfulness Study (AIM)
The goal of the AIM Study is to examine the effectiveness of Mindfulness Based Relapse Prevention (MBRP) versus Relapse Prevention (RP) for the treatment of Alcohol Use Disorders (AUD) by implementing an 8-week long intervention…
- Trial name
- NCT02994043
- Testing
- Mindfulness-Based Relapse Prevention Therapy, Relapse Prevention Therapy
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Denver
HIV-1-infection
Cellular Pharmacology and Platelet Effects of Abacavir and Lamivudine Anabolites
This study will evaluate the intracellular pharmacokinetics and platelet effects of abacavir (ABC), lamivudine (3TC), tenofovir alafenamide (TAF), and emtricitabine (FTC) in persons living with HIV that are receiving these…
- Trial name
- NCT04301661
- Testing
- Blood collection, Abacavir/lamivudine, Tenofovir alafenamide/emtricitabine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Contraception
Drospirenone-only Pill as Emergency Contraception
Emergency contraception (EC) provides an additional measure to help prevent pregnancy after unprotected intercourse or contraceptive failure.
- Trial name
- NCT05675644
- Testing
- Drospirenone-only pill
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Yoga, Obesity
Feasibility and Impact of Yoga in Obesity
Yoga may confer health benefits in people with overweight or obesity that enhance weight loss and weight loss maintenance. This study aims to investigate the feasibility of integrating yoga into an established behavioral weight…
- Conditions
- Yoga, Obesity, Weight Loss
- Trial name
- SYNERGY (NCT05031221)
- Testing
- Yoga + behavioral weight loss
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Peanut Allergies, Tree Nut Allergies
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies
Food allergies are now a major problem. These experiments involve getting blood from people with food allergies and from people without food allergies.
- Conditions
- Peanut Allergies, Tree Nut Allergies, Other Food Allergies
- Trial name
- NCT02192866
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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