Clinical trials: sponsored by University of Colorado, Denver
Opioid Use, Surgery
Shared Decision-Making Tool for Opioid Prescribing After Ambulatory Hand Surgery in Veterans
The purpose of this study is to determine if an educational patient-centered presentation reduced the amount of opioid pills requested and utilized by patients compared to standard of care group.
- Trial name
- NCT04625231
- Testing
- Educational Shared-Decision Making Tool
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Cesarean Section
Use of Cesarean Birth at Private Health Facilities in Lilongwe and Blantyre, Malawi
The purpose of the research study is to collect preliminary data to which future outcomes after implementing quality improvement projects or research will be compared.
- Trial name
- NCT04442997
- Where
- 3 sites in Malawi
- Volunteers
- 260 people
- Sponsor
- University of Colorado, Denver
Metastatic Breast Cancer, Solid Tumors
Phase I Study of MLN0128 and MLN8237 in Patients With Advanced Solid Tumors and Metastatic Triple-negative Breast Cancer
This is a phase Ib study designed to evaluate the safety and toxicity of the combination of Alisertib and MLN0128 in patients with advanced solid tumors with an expansion cohort in patients with previously treated metastatic TNBC.
- Trial name
- NCT02719691
- Testing
- Alisertib, MLN0128
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
Home Telemedicine to Optimize Health Outcomes in High-Risk Youth With Type 1 Diabetes
This study addresses the critical need for improving Type 1 Diabetes (T1D) health outcomes in high-risk youth (A1C=9-12%; ages 10-17 yrs) (AIC: glycated hemoglobin) where suboptimal glycemic control has severe acute and long-term…
- Trial name
- NCT03324438
- Testing
- Home Telehealth T1D C2oYoT1-HR, Personalized Behavioral Health, Personalized Adherence Feedback
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Total Knee Arthroplasty
Swelling Management After Total Knee Arthroplasty
The purpose of this feasibility study is to estimate the initial efficacy and feasibility of an inelastic compression garment donned immediately after TKA on peak swelling in 14 subjects.
- Trial name
- NCT04841356
- Testing
- Immediate Compression Garment
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Childhood Obesity
Environmental Influences on Early Childhood Obesity
Few treatments have been developed for young children with obesity from diverse backgrounds. The present study will develop and test an intervention designed to improve preschool obesity in Latino children.
- Trial name
- HHS (NCT02703688)
- Testing
- Healthy Homes, Usual Care
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Diabetes
Time Restricted Feeding and Metabolic Rhythms
Current guidelines for the prevention and treatment of obesity focus on caloric restriction diets and increasing physical activity, but long-term compliance to these strategies is poor.
- Trial name
- Rhythm (NCT04009239)
- Testing
- Time Restricted Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smoking
Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers
The goal of this study is to determine if a specific experimental brain stimulation technique can be used as a non-invasive way to reduce cigarette cravings in current smokers.
- Trial name
- NCT02590640
- Testing
- Repetitive transcranial magnetic stimulation, MagStim Rapid2
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Migraine, Migraine;Menstrual
The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users
A prospective, non-inferiority study to evaluate the pharmacokinetic effect of topiramate on serum Etonogestrel (ENG) levels in contraceptive implant users.
- Conditions
- Migraine, Migraine;Menstrual, Contraception
- Trial name
- NCT03335163
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Physical Disability
Patient-Centered, Interprofessional Approach to Improve Functional Outcomes in a Skilled Nursing Facility
During a hospital stay, older adults often become physically deconditioned and lose their ability to perform activities of daily living.
- Trial name
- NCT04300413
- Testing
- High-Intensity Rehabilitation plus Mobility (HeRo)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Heart Failure, Systolic, Heart Failure
A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators
The investigators goal is to assess real-world effectiveness of patient decision aids (PtDA) for high-risk decisions using the implantable cardioverter-defibrillator (ICD) as a model.
- Trial name
- NCT03374891
- Testing
- Educational video and/or handout
- Where
- United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Childhood Cancer, Survivorship
Sexual Function Screening in Childhood Cancer Survivors
This is a qualitative research study involving semistructured interviews and Think-Aloud methodology during completion of a clinical screening tool. All participants will undergo the same semistructured interviews.
- Conditions
- Childhood Cancer, Survivorship, Sexual Dysfunction
- Trial name
- NCT04066218
- Testing
- Interviews
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Breast Cancer Female, Overweight and Obesity
Combined Modality Exercise and Appetite in Breast Cancer Survivors
The overall aim of this research is to assess the feasibility of a 12-week combined aerobic exercise (AEx) and resistance exercise (REx) intervention and elucidate the impact of AEx/REx on several physiological and behavioral…
- Trial name
- CARE (NCT04576247)
- Testing
- Combined aerobic and resistance exercise
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Renal Transplant Patients
CNS Study of Patients Switching From Tacrolimus to Envarsus
This is a pilot study documenting the neurotoxic side effects including tremors in patients with a stable graft who are receiving Tacrolimus following kidney transplantation.
- Trial name
- NCT03270462
- Testing
- Envarsus XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Kaposi Sarcoma (KS), HIV
Strategies to Improve Kaposi Sarcoma (KS) Outcomes in Zimbabwe
Kaposi sarcoma (KS) is an AIDS-related cancer and is the most commonly reported cancer in Zimbabwe. If it is found early on, it may be treatable with antiretroviral therapy (ARVs) alone and this will improve general well-being…
- Trial name
- SIKO (NCT01764360)
- Testing
- KS structured clinical care training
- Where
- Zimbabwe
- Volunteers
- 1,024 people
- Sponsor
- University of Colorado, Denver
Sever's Disease
Comparison of Braces for Treatment of Sever's Disease
This study is to learn more about braces that may help young athletes diagnosed with Sever's disease. Young athletes with this diagnosis who are seen by a Sports Medicine doctor will be asked it they want to be a part of the…
- Trial name
- NCT03494647
- Testing
- Cheetah Heel Cup, The X Brace
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Surgical Site Infection, Vancomycin
Pharmacokinetics of Preoperative Vancomycin
A study of plasma and tissue vancomycin pharmacokinetics in pediatric surgical patients.
- Trial name
- NCT03453684
- Testing
- Administration of Vancomycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Hearing Loss, Sensorineural
Evaluation of Speech-in-noise Performance in Cochlear Implant Recipients With a CROS Device on the Contralateral Ear
Speech understanding in noise remains the greatest challenge for people using cochlear implants, particularly when the speech of interest comes from the side of the head opposite to the implant.
- Trial name
- NCT03867396
- Testing
- CROS, Hearing Aid, Cochlear Implant Alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Breast Feeding, Exclusive
Supplemental Nursing System Compared to Bottle Supplementation
This is a randomized controlled trial comparing the SNS to bottle feeding. This study will compare exclusive breastfeeding rates and breast milk feeding rates at discharge, day of life 14, and day of life 28 between neonates…
- Trial name
- NCT04638075
- Testing
- Supplemental Nursing System
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hospitalism, Flow or Discharge
Discharge in the AM
As hospitals around the country continue to work to manage a high patient census, provider prioritization of discharges is one low cost mechanism to help improve patient throughput and patient length of stay.
- Trial name
- NCT05370638
- Testing
- Rounding on discharging patients first
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver