Clinical trials: sponsored by University of Colorado, Denver
Conscious Sedation, Simple Lacerations Less Than 4 cm
A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
The objective of this project is to compare the sedative effects of intranasal midazolam versus inhaled nitrous oxide (N2O) for minor procedures in the pediatric emergency department.
- Conditions
- Conscious Sedation, Simple Lacerations Less Than 4 cm, Lumbar Punctures, Minor Incision Drainage of Abscesses Not Requiring Extensive Debridement
- Trial name
- NCT03085563
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Colorado, Denver
Diabetic Ketoacidosis, Type 1 Diabetes Mellitus
Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes
A frequent complication in the management of diabetic ketoacidosis (DKA) in children with type 1 diabetes is rebound hyperglycemia (blood glucose over 180 mg/dL) which increases the risk of re-developing DKA and can lengthen the…
- Trial name
- NCT03107208
- Testing
- Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diffuse Large B Cell Lymphoma
POLA+BR for Relapsed or Refractory DLBCL
This is a phase II multicenter, open-label study of polatuzumab vedotin administered by IV infusion in combination with standard doses of bendamustine (B) and rituximab (R) in transplant-eligible patients with relapsed or…
- Trial name
- NCT04535102
- Testing
- Polatuzumab Vedotin
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Brain Concussion, Musculoskeletal Injury
A Sports Injury Prevention Program to Reduce Subsequent Injuries After Concussion
The long-term goal of this research is to implement methods that healthcare providers can use across diverse clinical settings to (1) identify athletes at risk for (musculoskeletal) MSK injury when cleared to return to play (RTP)…
- Conditions
- Brain Concussion, Musculoskeletal Injury, Locomotion, Postural Balance
- Trial name
- NCT03917290
- Testing
- Neuromuscular training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Heart Failure, Quality of Life
Improving Quality of Life in Heart Failure
This research study has been designed to test the efficacy of telephone-delivered Problem-Solving Treatment (PST) for improving the quality of life (QoL) in outpatients with stable heart failure (HF).
- Trial name
- NCT03288194
- Testing
- Problem-Solving Treatment, Time Management
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Colorado, Denver
Severe Motility Disorder
FMT as a Treatment for Severe Motility Disorder
Many patients that are treated with anorectal malformations are fecally incontinent for life. A Bowel Management Program has been developed to help these patients by creating a daily enema regimen to keep them artificially clean…
- Trial name
- NCT04373252
- Testing
- FMT Lower Delivery (FMP 30)
- Sponsor
- University of Colorado, Denver
Decision Support Systems, Clinical, Heart Failure
An Implementation Model for Clinical Decision Support for Heart Failure Prescribing
The objective of this proposal is to compare clinical outcomes, implementation metrics (i.e., patient reach and clinician adoption), and clinician preferences of two designs (customized vs.
- Trial name
- NCT04028557
- Testing
- Decision Support Systems, Clinical
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Klinefelter Syndrome
TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY
This research study in infant males with Klinefelter syndrome (47,XXY) will learn more about the effect of testosterone on early health and development.
- Trial name
- TESTO (NCT03325647)
- Testing
- Testosterone Cypionate 200 Milligram/Milliliter Injectable Solution
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Claustrophobia, Anxiety
Pilot Trial of Hypnosis and Enhanced Communication In Patients Undergoing MRI
The overarching goal of this study is to enhance patient comfort during magnetic resonance (MR) exams by reducing anxiety and movement during the exam, thereby decreasing the time spent in magnetic resonance imaging (MRI) scanner…
- Conditions
- Claustrophobia, Anxiety, Magnetic Resonance Imaging
- Trial name
- NCT04520100
- Testing
- Clinical Hypnosis performed by the PI, Care by technician trained in empathic communication
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Community-acquired Pneumonia, Streptococcus Pneumoniae Infection
Determination of the Utility of Pfizer's Pneumococcal Urine Antigen Test in Children 5 Years of Age or Younger With Community Acquired Pneumonia in Guatemala
This prospective case-control study aims to evaluate the utility and establish laboratory thresholds for a multi-serotype urine antigen test for the diagnosis of pneumococcal community acquired pneumonia in children 5 years of…
- Trial name
- NCT03696303
- Testing
- Urinary antigen detection assay
- Where
- 3 sites in Guatemala
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Brain Concussion, Pediatric
Early Exercise to Improve Psychosocial Function After Pediatric Mild Traumatic Brain Injury
The investigators will test the central hypotheses according to the following Specific Aims: Aim 1. Determine if an individually prescribed exercise program initiated within the first week of mild traumatic brain injury can…
- Conditions
- Brain Concussion, Pediatric, Mild Traumatic Brain Injury, Psychological
- Trial name
- NCT04199247
- Testing
- Sub symptom aerobic exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Platelet-Rich Plasma
Platelet-Rich Plasma (PRP) for Treatment of Symptomatic Lumbar Facet Syndrome of the Spine
The purpose of this study is to investigate the feasibility of standardized autologous platelet rich plasma injections into osteoarthritic lumbar facet joints to treat back pain and improve patient function.
- Trial name
- NCT04522674
- Testing
- Autologous platelet rich plasma
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Colorado, Denver
Infantile Spasms, Non-Intractable
Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology
This study plans to learn more about how the use of new telemedicine technology can help with parental stress, costs, and overall satisfaction in care.
- Trial name
- NCT04086992
- Testing
- Remote monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Antisocial Behavior, Psychopathology
Age-17 Follow-up of Home Visiting Intervention
This study is a longitudinal follow-up of 670 primarily African-American women and their 17-year-old firstborn children enrolled since 1990 in a highly significant randomized controlled trial (RCT) of prenatal and infancy home…
- Conditions
- Antisocial Behavior, Psychopathology, Substance Use, HIV Infections
- Trial name
- MemphisY17 (NCT00708695)
- Testing
- Nurse Home Visiting
- Where
- United States
- Volunteers
- 1,880 people
- Sponsor
- University of Colorado, Denver
Liver Cancer
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients
This is a pilot study that uses a standard of care technique, Stereotactic Body Radiation Therapy (SBRT), in combination with Dynamic Contrast Enhanced Computed Tomography (DCE-CT) to determine if perfusion changes from SBRT of…
- Trial name
- NCT03891654
- Testing
- Dynamic Contrast Enhanced Computed Tomography
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents
This study evaluates the impact of the hybrid closed-loop insulin delivery systems on sleep in youth with type 1 diabetes and their parents.
- Trial name
- NCT04431947
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Diabetes, Pre-diabetes
Weight Loss and/or Exercise Training to Discover Muscle Lipids Related to Insulin Sensitivity
The investigators will use exercise training and weight loss to discover localized lipid species related to diabetes risk in people.
- Trial name
- NCT02043405
- Testing
- Weight loss and exercise training intervention, Weight loss Only Intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Primary Cervical Dystonia
Transcranial Electrical Stimulation for Cervical Dystonia
There are two phases. Phase I: A single visit which includes a screening, clinical scales, and a MRI scan with simultaneous tES/sham tES in a randomized block design.
- Trial name
- NCT03369613
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
This is a Phase I clinical trial of the FDA approved drug Glycerol Phenylbutyrate to see if phenylbutyrate can increase the removal of alpha-synuclein from the brain into the bloodstream.
- Trial name
- NCT02046434
- Testing
- Glycerol Phenylbutyrate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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