Clinical trials: sponsored by University of Colorado, Denver
Hepatocellular Carcinoma of the Liver, Subjects Eligible for Liver Transplantation
Bridge to Orthotopic Liver Transplantation (OLT) - Surefire Precision vs Endhole Embolization With DEBTACE
The purpose of this study will be to prospectively evaluate the outcomes of patients with hepatocellular carcinoma (HCC) who undergo DEB-TACE (drug-eluting bead trans-arterial chemoembolization) with the Surefire Precision…
- Trial name
- SPEED (NCT03170869)
- Testing
- Surefire Precision Infusion System
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Osteoporosis
Effect of Two Exercise Programs on Bone Strength and Architecture
Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than…
- Trial name
- NCT02636530
- Testing
- Ground Reaction Forces, Joint Reaction Forces
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Diabetes Nutrition Education for American Indian and Alaska Native Communities
This study involves pilot testing a newly developed diabetes nutrition education program for American Indian and Alaska Native adults with T2D.
- Trial name
- NCT04254653
- Testing
- American Indian and Alaska Native What Can I Eat?
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Movement Disorders
Leveraging Machine Learning to Effortlessly Track Patient Movement in the Clinic.
The objective of this study is the development of a system that will allow for the precise measurement of movement kinematics in a clinical exam setting using natural video from three cameras and machine learning to track points…
- Trial name
- NCT04074772
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Metastatic Medulloblastoma, High Risk Supratentorial PNET
Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET)
The purpose of this study is to study the efficacy of the combination of reduced dose craniospinal radiation (reduced from standard of care dosing at 36 Gy to 24 Gy) with concurrent carboplatin and vincristine administration for…
- Conditions
- Metastatic Medulloblastoma, High Risk Supratentorial PNET, Metastatic PNET
- Trial name
- NCT01542736
- Testing
- Carboplatin, Vincristine, 24 Gy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Cognitive Impairment, Executive Dysfunction
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and…
- Conditions
- Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT02122198
- Testing
- Leuprolide acetate, Estradiol, Medroxyprogesterone
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Melanoma
SunSmart Intervention in Schools
A prevention study to improve sun exposure behaviors in children after an educational classroom-based intervention.
- Trial name
- NCT03745872
- Testing
- Knowledge Assessment
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mild Cognitive Impairment
Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
Loss of slow wave sleep (SWS) is common in mild cognitive impairment (MCI) and Alzheimer's disease, and is thought to worsen thinking, memory and brain degeneration.
- Trial name
- NCT03112902
- Testing
- Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Partial Edentulism
Histologic Comparison of Healing After Tooth Extraction With Ridge Preservation Using Two Different Xenografts
The purpose of this study is to compare the speed of bone healing of the two most commonly used xenografts on the market, Bio-Oss® and Salvin-Oss® using a tooth extraction ridge preservation model in participants scheduled for…
- Trial name
- NCT03769376
- Testing
- Bio-Oss®, Salvin-Oss®
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes
Effectiveness of Adding Subcutaneous Long-Acting Detemir to Insulin Drip Therapy Compared With Standard Insulin Drip Therapy
The investigators anticipate that the use of Detemir will decrease the duration of an insulin drip, the dose of short-acting insulin in the drip, hospital and ICU (intensive care unit) length of stay, improve glycemic control…
- Trial name
- NCT01186003
- Testing
- Detemir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes
People who are overweight or who have type 2 diabetes mellitus (T2DM) have higher levels of certain fats in their blood. The blood vessels and heart of most of these individuals do not work normally and people with T2DM also have…
- Trial name
- AcT2 (NCT01580813)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Pancreatic Cancer
Preoperative Exercise in Pancreatic Cancer
The purpose of this study is to investigate the effects of a preoperative exercise program in patients with pancreatic cancer preparing for surgery.
- Trial name
- NCT02648880
- Testing
- Exercise program, Standard Care
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Microsatellite Instability High, Mismatch Repair Deficiency
Anti-PD-1 +/- RT for MSI-H Solid Tumors
To determine if the out-of-field ORR is improved with the addition of radiation therapy to anti-PD-1 for patients with MSI-H/dMMR metastatic solid tumors.
- Conditions
- Microsatellite Instability High, Mismatch Repair Deficiency, Colorectal Cancer
- Trial name
- NCT04001101
- Testing
- RT and Anti-PD-1, Anti-PD-1
- Where
- United States
- Sponsor
- University of Colorado, Denver
Esophageal Cancer, Gastroesophageal Junction Cancer
STRENGTH Expansion
Patients seen in the EGMDC (Esophageal and Gastric Multidisciplinary Clinic) for treatment planning who are recommended to receive neoadjuvant treatment followed by surgery at UCCC Metro will be offered enrollment into the study.
- Trial name
- NCT04520867
- Testing
- STRENGTH
- Where
- United States
- Sponsor
- University of Colorado, Denver
Mild Cognitive Impairment
ENgaging in Advance Care Planning Talks Group Visit Intervention for Cognitive Impairment
The Advance Care Planning Group Visit intervention is a new intervention that uses the strengths of group visits to promote advance care planning conversations and documentation.
- Trial name
- ENACT-aMCI (NCT03711396)
- Testing
- Advance Care Planning Group Visits
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
IUGR, Pregnancy
Transplacental Gradients and Transport in Intrauterine Growth Restricted (IUGR) Pregnancies Compared to Normal Pregnancies.
The purpose of this study is to determine whether the transplacental gradients for 6 polyols and mannose are altered in intrauterine growth restricted (IUGR) pregnancies compared to normal pregnancies and b) to determine the…
- Trial name
- NCT02397291
- Testing
- Mannose, Myoinositol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cancer
ALIGN Intervention in Patients With Advanced Cancer Discharging to a SNF
This is a single arm, pre-post, pilot study assessing the feasibility and acceptability of the ALIGN intervention in metastatic adult cancer patients discharging to local area SNFs.
- Trial name
- ALIGN (NCT04882111)
- Testing
- ALIGN
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
COVID
Compensatory Reserve Index (CRI) for Management of COVID-19
The FDA has approved the CipherOx CRI T1 Tablet for use in subjects aged 19-36, and that this study aims to evaluate the device in subjects aged outside of this range and is being used off label.
- Trial name
- NCT04457817
- Testing
- CRI
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Respiratory Pathogens, Upper Respiratory Tract Illness
The RAPID Trial: Assessing Point-of-care Influenza and Other Respiratory Virus Diagnostics
The RAPID trial is a randomized controlled trial that looks at the clinical impact of a rapid respiratory test in a pediatric emergency department.
- Conditions
- Respiratory Pathogens, Upper Respiratory Tract Illness, Lower Respiratory Tract Illness, Acute Respiratory Infection
- Trial name
- RAPID (NCT03756753)
- Testing
- Results available to provider
- Where
- United States
- Volunteers
- 913 people
- Sponsor
- University of Colorado, Denver
Patient Education, Virtual Reality
Virtual Reality in Imaging Review for Cancer Patients
Patients with cancer and their caregivers may have difficulty understanding the site and extent of their disease. Poor comprehension may negatively impact patients and caregivers, leading to increased anxiety, reduced compliance…
- Conditions
- Patient Education, Virtual Reality, Diagnostic Imaging, Cancer Patient
- Trial name
- NCT04469478
- Testing
- Survey and interview
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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