Clinical trials: sponsored by University of Colorado, Denver
Opioid Use
24-hour Oral Morphine Equivalent Based Opioid Prescribing After Surgery
The investigators will utilize the electronic health record to individualize pain therapy in surgical patients after hospital discharge using last 24-hour opioid intake as the decision variable for the amount of opioid pain pills…
- Trial name
- NCT04043143
- Testing
- Arm 1 Prescription As Usual, Arm 2 Prescription Tool Intervention
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder, PREG1
The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid…
- Conditions
- Cannabis Use Disorder, PREG1, Drug Use, Fetal Exposure During Pregnancy
- Trial name
- NCT03718520
- Testing
- no intervention, this is a purely observational study
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Morning Versus Evening Exercise for Adults With Overweight and Obesity
The purpose of this pilot study is to determine the feasibility and acceptability of randomizing adults with overweight and obesity to an exercise intervention of either prescribed morning aerobic exercise (AM-EX) or prescribed…
- Trial name
- TIC-TOC (NCT04262115)
- Testing
- AM-EX, PM-EX
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder, Child Development Disorders, Pervasive
Trial of Therapeutic Horseback Riding in Children and Adolescents With Autism Spectrum Disorder
This study is being carried out to learn more about the effects of Therapeutic Horseback Riding (THR) for children and adolescents with an autism spectrum disorder (ASD).
- Trial name
- NCT02301195
- Testing
- Therapeutic horseback riding, Barn Activity Intervention
- Volunteers
- 209 people
- Sponsor
- University of Colorado, Denver
Dental Caries
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
This study will evaluate effectiveness of a urethane dimethacrylate (UDMA)-quaternary ammonium methacrylate (K18) resin (UDMA-K18) smooth surface sealant to prevent biofilm attachment to tooth surfaces thereby eliminating the…
- Trial name
- K18 (NCT03306433)
- Testing
- UDMA-K18 smooth surface sealant
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lambert Eaton Myasthenic Syndrome
Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton Syndrome
To learn more about the effect of 3, 4-Diaminopyridine (3,4-DAP) on patient diagnosed with Lambert-Eaton myasthenic syndrome (LEMS).
- Trial name
- 3 4-DAP (NCT01825395)
- Testing
- 3, 4-Diaminopyridine
- Where
- United States
- Sponsor
- University of Colorado, Denver
Patient Engagement, Medication Optimization
Electronic Health Record-leveraged, Patient-centered, Intensification of Chronic Care for HF
The EPIC-HF study will test the effectiveness of a patient empowerment and activation for optimization of Heart Failure with reduced Ejection Fraction (HFrEF) medication plans.
- Conditions
- Patient Engagement, Medication Optimization, Heart Failure With Reduced Ejection Fraction, Patient Activation
- Trial name
- EPIC-HF (NCT03334188)
- Testing
- Patient engagement materials, No Intervention--Usual Care
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- University of Colorado, Denver
Opioid Use
UControlPain App (This is the Official IRB Title)
It is estimated that 77% of all Americans own a smartphone and the use of health apps has doubled in the last two years. Consistent with this development, over half of US smartphone owners have downloaded a health-related mobile…
- Trial name
- NCT03833648
- Testing
- UControl Pain App with Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder
Facing Your Fears in Schools: Implementing a CBT Program for Students With ASD or Other Special Learning Needs
The overall goal of the project is to develop a feasible, effective and sustainable school-based program to manage anxiety in elementary and middle school students with Autism Spectrum Disorder (ASD) and other special learning…
- Trial name
- FYF-SB (NCT03685474)
- Testing
- Facing Your Fears - School Based, Usual Care
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart…
- Trial name
- EMERALD (NCT01808690)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Hyperinsulinemic Hypoglycemia, Post Gastrointestinal Tract Surgery Hypoglycaemia
Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia
Somatostatin analogues are a last resort for medical intervention in hyperinsulinemic hypoglycemia (HH). The hypoglycemia is very debilitating and can be even life threatening.
- Trial name
- NCT03103009
- Testing
- Pasireotide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
COVID, Trauma
The Use of Ultrasound in Establishing COVID-19 Infection as Part of a Trauma Evaluation
The current COVID-19 pandemic is providing healthcare organizations with considerable challenges and opportunities for rapid cycle improvement efforts, in diagnostic and patient management arenas.
- Conditions
- COVID, Trauma, Ultrasound
- Trial name
- NCT04340479
- Testing
- Ultrasound lung imaging as part of FAST+ evaluation
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Resistance Training and Appetite Regulation
This study plans to learn more about how resistance training impacts appetite and the brain's response to food. The study will be evaluating how the brain responds to food images as well as how behaviors and hormones change with…
- Trial name
- NCT03985787
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid Use
Self-reported Usage Patterns of Opioid Analgesic Medications After Surgery
The primary objective of this study is to better understand post-discharge utilization of prescribed opioid analgesic medications following surgery.
- Trial name
- NCT03034278
- Testing
- Not applicable - no intervention
- Where
- United States
- Volunteers
- 785 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension
Pharmacogenetic Prediction of Metoprolol Effectiveness
The investigators will prospectively follow a population of patients with uncontrolled high blood pressure beginning metoprolol succinate therapy to determine the drug effect in an observational clinical trial.
- Trial name
- NCT02293096
- Testing
- metoprolol succinate, Genotyping, CYP2D6 Phenotyping
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- University of Colorado, Denver
Hepatitis C Virus
Concentration-Controlled Ribavirin for the Treatment of Patients With Chronic Hepatitis C Virus Infection
The purpose of this study is to determine if concentration-controlled ribavirin dosing can achieve a targeted level of plasma exposures and if it appears safe and effective compared with standard weight-based ribavirin dosing.
- Trial name
- NCT01097395
- Testing
- ribavirin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Colorado, Denver
Type1diabetes, Fear of Hypoglycemia
Intervention to Reduce Fear of Hypoglycemia and Optimize Type 1 Diabetes Outcomes
The overall objective and Primary Aim of this Limited Competition: Small Grant Program (R03) is to address the critical need of identifying and decreasing fear of hypoglycemia, which will be accomplished by conducting a pilot…
- Trial name
- NCT03039933
- Testing
- Fear of Hypoglycemia, Treatment As Usual
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes
Type 1 diabetes (T1D) continues to be a disease plagued by hyperglycemia, insulin resistance (IR), and increased cardiovascular disease (CVD) despite advances in insulin delivery and glucose monitoring.
- Trial name
- NCT02544321
- Testing
- Bromocriptine
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Granuloma, Tracheostomy
Treatment of Tracheostomy Granulomas
This study plans to learn more about the different ways used to treat tracheostomy granulomas. Investigators want to see which standard of care method (steroid application, silver nitrate, or betadine) is more successful in…
- Trial name
- NCT02116608
- Testing
- Betadine, Silver Nitrate, Hydrocortisone Butyrate Cream, 1.0%
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Insulin Pump to Multiple Daily Injection Transition Clinical Trial
This randomized controlled, two arms, investigator initiated, intervention study is aimed to examine an investigational approach in contrast to the clinical standard of 1:1 dose basal insulin conversion in an attempt to lower the…
- Trial name
- TRANSITION (NCT03987191)
- Testing
- Multiple daily ijnection using Insulin Degludec and Insulin Aspart
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Colorado, Denver
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