Clinical trials: sponsored by University of Colorado, Denver
Older Adults (65 Years and Older), Fall Prevention
Modifying the Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department for Telehealth
The goal of this clinical trial is to determine the feasibility of eGAPcare, a telehealth modification of the GAPcare fall prevention intervention, in older adults in a community emergency department.
- Conditions
- Older Adults (65 Years and Older), Fall Prevention, Telehealth, Emergency Department
- Trial name
- eGAPcare (NCT07034287)
- Testing
- Telehealth physical therapy and pharmacy consultation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Metastatic Colorectal Cancer (CRC)
Novel Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer
The overall objective of this study is to learn whether a newly developed couple-based mindfulness program (Mindful PaCT) is practical to complete (feasible), helpful and well-received (acceptable), and relevant for patients with…
- Trial name
- NCT07759921
- Testing
- Couple-based Mindfulness Intervention, Health and Wellness Education Control Condition
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Amputation, Diabetes Mellitus
Dysvascular Amputation Self-Management of Health
The purpose of this study is to determine if walking biobehavioral intervention improves physical activity after dysvascular lower limb amputation.
- Conditions
- Amputation, Diabetes Mellitus, Peripheral Artery Disease
- Trial name
- DASH (NCT04083456)
- Testing
- Walking Biobehavioral Intervention, Attention Control
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Colorado, Denver
Contraception
Etonogestrel Implant as Emergency Contraception
The investigators propose a single site, single arm, open label mechanism of action pharmacodynamic pilot study of etonogestrel implant insertion prior to an luteinizing hormone (LH) surge.
- Trial name
- NCT05237141
- Testing
- Etonogestrel implant
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Enhanced Recovery After Surgery, Gynecologic Disease
ERAS in Pediatric & Adolescent Gynecology Preoperative Counseling
The Investigator propose a randomized trial that will assess whether participant involvement in pre-operative counseling for ERAS improves post-surgical pain scores.
- Trial name
- NCT04963751
- Testing
- Enhanced Recovery After Surgery (ERAS) Counseling to Patients, Enhanced Recovery After Surgery (ERAS) Counseling to Caregiver
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis (MS) Relapsing Remitting
Prospective Evaluation of De-Escalation From antiCD-20 Therapies to Dimethyl Fumarate (Tecfidera) or Diroximel Fumarate (Vumerity)
The investigators propose a multi-center pilot study, which aims to evaluate safety and efficacy of fumarates as de-escalation therapy in clinically stable MS patients previously treated with anti-CD20 therapy.
- Trial name
- NCT07757568
- Testing
- Vumerity, Tecfidera
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Migraine, Migraine in Adolescence
Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain
The goal of this study (supported by and included in the NIH HEAL Initiative: https://heal.nih.gov/) is to learn if a fully virtual study comparing two telehealth group interventions for adolescents with migraine is feasible and…
- Trial name
- HEADS-UP (NCT07513662)
- Testing
- BREATHE with Headache (BREATHE-HA), Enhanced Standard-of-Care: Headache Education
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Acute Myeloid Leukemia
Venetoclax and Azacitidine for Non-Elderly Adult Patients With Acute Myeloid Leukemia
This study aims to treat non-elderly adult patients, who were previously untreated for acute myeloid leukemia, using venetoclax and azacitidine.
- Trial name
- NCT03573024
- Testing
- Azacitidine, Venetoclax
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Cancer, Metastatic Cancer
Biomarkers of Immune-Related Toxicity
This is a single-center, correlative pilot study evaluating potential biomarkers predictive of immune-related adverse events associated with immune checkpoint inhibitor therapy.
- Trial name
- NCT03409016
- Testing
- Blood Testing
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Timing Intervention of Morning Versus Evening Exercise
The investigators are doing this study to learn more about how exercising at different times of the day (morning versus evening) affects body weight, sleep, eating patterns, and other factors.
- Trial name
- TIMEX (NCT05153252)
- Testing
- Morning Exercise, Evening Exercise
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Colorado, Denver
Self-injury, Suicidal Ideation and Behavior
Pilot Trial of an Emotion Regulation and Executive Functioning Intervention for Self-Injurious Thoughts and Behaviors (SITBs) in Children
The goal of this study is to develop and test an outpatient intervention for preadolescents (ages 7-12) with self-injurious thoughts and behaviors (SITBs). The main questions it aims to answer are: 1.
- Conditions
- Self-injury, Suicidal Ideation and Behavior, Executive Functioning, Emotion Regulation
- Trial name
- NCT07281365
- Testing
- Treatment as usual (TAU), Preadolescent SITB Intervention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Diabetic Kidney Disease, Hyperuricemia
Uric Acid Lowering Trial in Youth Onset T2D
Adolescents and young adults with youth-onset type 2 diabetes (T2D) are disproportionally impacted by hyperuricemia compared to non-diabetic peers and youth with type 1 diabetes (T1D).
- Conditions
- Diabetic Kidney Disease, Hyperuricemia, Diabetes, Diabetes Mellitus, Type 2
- Trial name
- ULTRA-T2D (NCT03899883)
- Testing
- Pegloticase 8 MG/ML [Krystexxa]
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Kidney Diseases, Chronic Kidney Diseases
NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities
The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD.
- Trial name
- NAV-Kidney (NCT06810622)
- Testing
- Community health worker intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of Colorado, Denver
Enhanced Assess, Acknowledge, and Act Sexual Assault Resistance Program With Alcohol and Cannabis Content
Development of an Alcohol, Cannabis, and Sexual Assault Risk Reduction Program for High Risk College Women
The goal of this clinical trial is to assess the feasibility of the Enhanced Assess, Acknowledge, and Act Sexual Assault Resistance Program with alcohol and cannabis content (EAAA+) in undergraduate college women between ages…
- Trial name
- NCT07726004
- Testing
- Enhanced Assess, Acknowledge, and Act Sexual Assault Resistance Program, Assessment Only Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Endometrioid Ovarian Cancer, Primary Peritoneal Cancer
Cirtuvivint/Olaparib in Breast Cancer Susceptibility Gene/Homologous Recombination Deficiency Platinum Resistant Ovarian Cancer
The purpose of this study is to learn about the safety and tolerability of Cirtuvivint in combination with Olaparib in platinum resistant ovarian cancer.
- Conditions
- Endometrioid Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT06856499
- Testing
- Cirtuvivint, Olaparib
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Lactation, Weight Loss
Effects of GLP-1 RAs on Human Lactation Outcomes
There is increasing interest in using GLP-1 Receptor Agonist (GLP-1 RA) medications after pregnancy. This study is designed to determine if these medications affect breastmilk production or the nutritional makeup of breastmilk.
- Trial name
- NCT07720414
- Testing
- Injected GLP-1 Receptor Agonists and Dual Agonists
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Soft Tissue Sarcoma (STS)
5-AminoLevulinic Acid Aided Resection Margins in Sarcoma
The goal of this study is to learn if the intervention using a fluorescent agent 5-Aminolevulinic acid (5-ALA) to aid in the surgical approach to visualize the soft-tissue sarcoma (STS) during surgical resection.
- Trial name
- 5-ALARMS (NCT07038278)
- Testing
- 5-ALA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Menopause, Menopause Hot Flashes
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
What if midlife women, who are inherently at an increased risk for future cardiometabolic disease due to transitioning into menopause, had access to a suite of evidence-based health interventions? Could these interventions reduce…
- Conditions
- Menopause, Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular
- Trial name
- NCT06975111
- Testing
- Metformin, semaglutide, Anti-hypertensives
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infertility, Female, Obesity
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus.
- Trial name
- NCT06686537
- Testing
- Estradiol Patches
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hospice Decision Making
Underutilization of Hospice in Older African Americans
Despite the documented benefits of hospice, less than 2 million people utilize hospice services annually. Underuse disparities are extreme across race and ethnicity as White Americans comprise 85% of all hospice enrollees.
- Trial name
- NCT04458090
- Testing
- A decision aid for patients considering Hospice care.
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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