Clinical trials: completed, sponsored by University of Florida
Sepsis
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- NCT02711709
- Testing
- Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Diarrhea, Cholera
Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea
Diarrhea remains a leading killer of children in need of better treatments.
- Trial name
- ORS (NCT05814042)
- Testing
- Current standard control ORS (oral rehydration solution)
- Where
- Bangladesh
- Volunteers
- 396 people
- Sponsor
- University of Florida
Chronic Low-back Pain
Integrative Breathwork Intervention for Chronic Pain
The proposed research is to develop and refine a multicomponent breathwork intervention, Guided Respiration Mindfulness Therapy, and to iteratively evaluate its feasibility, acceptability, and plausibility for clinically…
- Trial name
- NCT06546956
- Testing
- Integrative Breathwork Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Chronic Pain
Group Integrative Breathwork for Chronic Pain
The aim of the proposed research is to iteratively develop, pilot test, and refine an integrative breathwork intervention that is suitable for group delivery to individuals with chronic pain.
- Trial name
- NCT06977984
- Testing
- Integrative Breathwork Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Asthma
AIM2ACT: A Mobile Health Tool to Help Adolescents Self-Manage Asthma
The aim is to test the efficacy of AIM2ACT and long-term maintenance of treatment effects in a fully-powered randomized controlled trial with 160 early adolescents with poorly controlled persistent asthma, ages 12-15 years, and a…
- Trial name
- AIM2ACT (NCT04448002)
- Testing
- AIM2ACT, mHealth Attention Control Condition
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Florida
Aging
The Fuel and Rhythm (FAR) Phase 2 Study
Both fuel metabolism and circadian rhythms have emerged as important targets to improve cellular and mitochondrial health and ultimately affect function in older adults.
- Trial name
- NCT05482711
- Testing
- Time Restricted Eating Intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sickle Cell Disease, Stress
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
The goal of this research study is to reduce stress and improve sickle cell disease (SCD) pain control and sleep quality with less opioid use by determining the feasibility of an intervention with self-management combined…
- Conditions
- Sickle Cell Disease, Stress, Pain
- Trial name
- ESPIRITU (NCT06580067)
- Testing
- Pray Until Something Happens (PUSH), Self-monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
To Compare Lung Transplant Outcomes Between Study Patients and Standard Patients Who Have Already Undergone Lung Transplantation by Conventional Procedures, Lung Transplant
Planned Semi-Elective Lung Tx Study
When suitable donor lungs become available for a consented recipient, and the donor cross clamp time occurs between 6pm and 4am, the transplant procedure (anesthesia starting time) will be allowed to be moved to a 6am start or…
- Trial name
- NCT04601818
- Testing
- Experimental: Preserving of Donor Lungs
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Florida
Exercise Program, Standard Care Control
Home-based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors - HEAL Sepsis Trial
Older sepsis survivors have poor physical function and need post-sepsis physical rehabilitation. Often times, sepsis survivors live far from research facilities and do not have access to rehabilitation services.
- Trial name
- NCT05568511
- Testing
- App-based exercise program, Standard of Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Duchenne Muscular Dystrophy (DMD)
Twice Weekly Steroids and Exercise as Therapy for DMD
The study team will determine the potential of low dose twice weekly prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular…
- Trial name
- NCT04322357
- Testing
- Prednisone, Exercise Training on standard steroid regimen, Exercise training on twice-weekly steroids
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Knee Osteoarthritis, Osteoarthritis
Understanding Cognition, Oxytocin & Pain in Elders
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies.
- Trial name
- UCOPE (NCT03878589)
- Testing
- Oxytocin (OT)
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Florida
Alcohol Use Disorder, Attention Deficit Hyperactivity Disorder
Methylphenidate and Response to Alcohol Cues Pilot Study
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT06063200
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sarcoidosis, Precapillary Pulmonary Hypertension
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.
- Conditions
- Sarcoidosis, Precapillary Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- SAPPHIRE (NCT03814317)
- Testing
- Inhaled Treprostinil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Rotation of Tooth
Clinical Trial to Compare Clear Aligners' Auxiliaries on Rotational Accuracy
This randomized clinical trial aims to assess the effectiveness of optimized attachments, IPR and a combination of the two techniques on the rotational accuracy of canines with clear aligners
- Trial name
- NCT06418984
- Testing
- auxiliary
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Musculoskeletal Diseases
Effects of a Very Low Carbohydrate Ketogenic Diet or Mediterranean Diet on Markers of Musculoskeletal Health in Older Adults
Preclinical data indicate that very low carbohydrate ketogenic diets (KD) may prevent progression of age-related sarcopenia (skeletal muscle decline) but also may disturb bone metabolism.
- Trial name
- NCT06203392
- Testing
- Very low carbohydrate ketogenic diet, Mediterranean diet
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Frailty, Frail Elderly
Synergizing Home Health Rehabilitation Therapy
The objective of this project is to pilot test an ADL (activities of daily living)-enhanced program as an adjuvant therapy to usual home health rehabilitation to improve patient outcomes.
- Conditions
- Frailty, Frail Elderly, Occupational Therapy, Activities of Daily Living
- Trial name
- NCT05411393
- Testing
- ADL-enhanced program, Usual home health rehabilitation therapy
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Florida
Friedreich Ataxia
Measurement of Frataxin mRNA in Biofluids
The purpose of this research study is to determine a way to measure frataxin messenger RNA (mRNA) in fluids such as blood and cerebrospinal fluid (CSF) from patients with Friedreich's ataxia (FRDA).
- Trial name
- NCT06496451
- Testing
- Spinal tap for CSF collection, Venipuncture for blood sample
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Health Care Utilization
Investigating the Influence of Catheter Advancement Techniques on Needle Tip Movement During Intravenous Insertion
This proposed study aims to fill this gap by investigating whether needle tip movement during catheter advancement is affected by whether the individual performing the insertion pushes the catheter off the needle themselves or if…
- Trial name
- NCT06518187
- Testing
- Assessing the impact of three different catheter advancement techniques on needle tip movement during intravenous insertion
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Essential Tremor, Parkinson's Disease
The Motor Network in Essential Tremor: Mechanisms of Therapy
Essential tremor (ET) is among the most common movement disorders, and is the most prevalent tremor disorder. It is a progressive, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an…
- Trial name
- NCT02712515
- Testing
- Deep brain stimulation implantation surgery, Ad-Tech Medical Instrumentation Corp. electrodes/subdural strips, FHC Guideline 4000+ system and/or Medtronic RC+S
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Dementia With Lewy Bodies
The PACE-DLB Study
The PACE-DLB Study is for people with at least moderate dementia with Lewy bodies (DLB) and their primary caregiver. The study's goals are to learn more about the experiences of people with DLB and their caregivers as DLB…
- Trial name
- NCT04829656
- Where
- 5 sites in United States
- Volunteers
- 378 people
- Sponsor
- University of Florida