Clinical trials: open to volunteers, sponsored by University of Florida
Chronic Knee Pain
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
This study aims to determine analgesic and anti-inflammatory effects of dual-wavelength PBM in people with symptomatic knee OA.
- Trial name
- EPIC-KO (NCT07079969)
- Testing
- Photobiomodulation therapy (PBM) device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sepsis, Trauma Injury
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells.
- Trial name
- NCT05110937
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Florida
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization
This study evaluates whether multiparametric chest magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), performed without any contrast material, can distinguish malignant from benign lung lesions that were…
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
- Trial name
- NCT07768046
- Testing
- Multiparametric chest MRI with diffusion-weighted imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Fibromyalgia, Rheumatoid Arthritis
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated…
- Trial name
- NCT05277025
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Florida
Concussion, Depression
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Concussion and depression have long been recognized to be intertwined pathologies.1-3 Although female athletes are more likely to suffer from mental health symptoms than males athletes following a concussion,2 research in this…
- Trial name
- NCT07507214
- Testing
- ONE-D TMS protocol and d-cycloserine (125 mg)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Distal Femur Fracture
Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)
Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence.
- Trial name
- NCT05792189
- Testing
- Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Diabetes, Cervical Cancer (Early Detection)
Improving Cervical Cancer Prevention Among Women Living With Chronic Conditions.
Our overarching goal is to adapt and test the PINPOINT intervention -PatIent Navigation for the Prevention of CervIcal CaNcer inTervention.
- Conditions
- Diabetes, Cervical Cancer (Early Detection), Obesity & Overweight
- Trial name
- PINPOINT (NCT07351110)
- Testing
- patient navigation and self-collection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognition, Gut Microbiome
The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study
This project uses a hybrid trial design to evaluate two biomedical interventions targeting the gut-brain axis. One intervention is portable Transcutaneous Vagus Nerve Stimulator, tVNS, that is hypothesized to stimulate the…
- Trial name
- NCT05090267
- Testing
- Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Cervical Cancer Screening Methods
Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women
Project CONTINUITY (Connecting You to Care in the Community) was developed to increase adherence to cervical cancer screening regimens from initial screening to needed follow-up care by (1) providing personalized approaches to…
- Trial name
- NCT05390567
- Testing
- Participant Choice of HPV Self-Test, Survey: Participant cancer history and cervical cancer prevention/screening knowledge, Participant Choice of Standard of Care in-clinic Pap-test
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity
Supporting Decisions on Lifestyle Change
This study will test the effects of a brief, individually tailored intervention aiming to increase initiation of comprehensive behavioral weight loss treatment on weight.
- Trial name
- NCT06206954
- Testing
- MyHealthPath Tool, MyHealthPath Guide
- Where
- United States
- Volunteers
- 864 people
- Sponsor
- University of Florida
Lung Transplantation, End Stage Lung Disease
Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients
The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these measures relate to physical performance, symptoms, and recovery after…
- Trial name
- NCT07747337
- Testing
- Respiratory and Limb Muscle Assessment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Behavior and Behavior Mechanisms, Child Behavior
Dental-Child Interaction Training
The goal of this behavioral, interventional clinical trial is to provide a specialized workshop training for dental providers (e.g., dentists, hygienists, assistants) to improve interactions with young children (2-10 years old)…
- Trial name
- DCIT (NCT06138405)
- Testing
- Immediate intervention Group, Delayed intervention (control) Group
- Where
- 4 sites in United States
- Volunteers
- 5,808 people
- Sponsor
- University of Florida
Aging
Neural Control of Gait & Navigation in ADRD
Brain network segregation, or independent functioning, declines with age and is associated with slower walking speed. Here, the investigators will determine the extent to which brain vestibular network segregation can be altered…
- Trial name
- NCT06501820
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mobility Limitation, Cognitive Impairment
Living Independence Through Functional Training
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.
- Trial name
- LIFT (NCT07125378)
- Testing
- Task-oriented resistance exercise
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Essential Tremor, Essential Tremor (ET)
Circadian Adaptive DBS in Essential Tremor
Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the…
- Conditions
- Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
- Trial name
- NCT06635811
- Testing
- Circadian Adaptive DBS, Conventional DBS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Cancer, Food Deprivation
The Florida ASCENT Study
The goal of this clinical trial is to adapt, implement, and evaluate MyCarePulse and ASCENT patient navigator to overcome barriers to care among patients with cancer.
- Conditions
- Cancer, Food Deprivation, Food Habits, Food Selection
- Trial name
- NCT07042243
- Testing
- MyCarePulse and ASCENT PN
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Parkinson Disease, Idiopathic
The Impact of Deep Brain Stimulation on Speech and Swallow Function in Parkinson Disease
Nearly one-million people in North America are now living with Parkinson's disease (PD), and that number is projected to rise to nearly 1.2 million by 2030.
- Trial name
- NCT07026734
- Testing
- Deep brain stimulation surgery - GPi, Deep Brain Stimulation Surgery - STN
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6
Interposed Nucleus aDBS for Ataxia
This is a single-center, open-label study designed to evaluate the feasibility, safety, and preliminary efficacy of cerebellar adaptive deep brain stimulation (aDBS) in adults with spinocerebellar ataxia type 6 (SCA6).
- Trial name
- NCT07325487
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Obesity & Overweight, Obese Adolescents
A Study Comparing Continuous Glucose Monitoring Augmented Nutritional Counseling and Standard of Care Treatment Strategies in a Three-Month Nutrition Intervention
The objective of this project is to determine the feasibility of introducing CGMs to adolescent patients with obesity and pre-diabetes (Hemoglobin A1C: HbA1C between 5.7-6.5%) to determine whether their eating habits and…
- Conditions
- Obesity & Overweight, Obese Adolescents, Metabolic Abnormalities
- Trial name
- NCT07714759
- Testing
- Use of an unblinded CGM device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida