Clinical trials: open to volunteers, sponsored by University of Florida
Kinematics
Biomechanics/Motion Analysis Laboratory Data Bank
The purpose of the data bank is to collect data on joint motion.
- Trial name
- NCT00160771
- Testing
- Joint Motion Analysis
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Florida
Heart Transplant Rejection, Immune Suppression
Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients
We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nonadherence remains a primary cause of late acute rejection (LAR)…
- Conditions
- Heart Transplant Rejection, Immune Suppression, Pediatric Heart Transplant, Medication Nonadherence
- Trial name
- NCT05732779
- Testing
- DOT intervention
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Adults
Enhancing Rehabilitation in Aging Study (ERAS)
Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity.
- Trial name
- NCT07704385
- Testing
- Istradefylline 20 mg, Acute Intermittent Hypoxia (AIH)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking.
- Trial name
- NCT06911229
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Hepatocellular Carcinoma
AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma
This study will test the hypothesis that a novel combination of three drugs (sorafenib, sonidegib, and irinotecan), in conjunction with individually optimized doses, can be safely administered and lead to improved clinical…
- Trial name
- NCT05669339
- Testing
- Irinotecan, Sonidegib, Sorafenib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Bile Duct Cancer, Gall Bladder Cancer
Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types
Checkpoint inhibitor therapy represents a significant advance in cancer care. The interaction between PD-1 and PD-L1 induces immune tolerance, and the inhibition of this interaction is an effective treatment strategy for numerous…
- Conditions
- Bile Duct Cancer, Gall Bladder Cancer, Breast Cancer, Neuroendocrine Tumors
- Trial name
- NCT05000294
- Testing
- Atezolizumab, Tivozanib
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Lung Transplant, GERD
The Effect of the Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Recipients
A prospective, open label, study designed to assess the affect of the Reflux Band® UES Assist Device (Reflux Band) on reflux in patients that have undergone lung transplantation.
- Trial name
- Reflux Band (NCT03886961)
- Testing
- Reflux Band
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
OCD
Paired tVNS With ERP in OCD
In the proposed investigation, the investigator will develop pilot data for the use of tVNS (transcutaneous vagal nerve stimulation) to enhance efficacy of exposure and response prevention therapy (ERP) to improve treatment…
- Trial name
- NCT05580614
- Testing
- tVNS
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Florida
Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia
Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit
Premature infants are susceptible to complications related to infrequent and non-standardized oral care. Although the benefits of frequent standardized oral care are known to reduce oral dysbiosis (increased level of potentially…
- Conditions
- Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia, Respiratory Disease
- Trial name
- NCT06000761
- Testing
- Standardized oral Care
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Florida
Cleft Lip and Palate
Cleft Lip and Palate Treatment Outcomes Study
Infants with cleft lip and palate often benefit from presurgical infant orthopedic treatment before surgical repair. Multiple standard of care approaches are selected based on each infant's clinical presentation and family…
- Trial name
- NCT07687537
- Volunteers
- 100 people
- Sponsor
- University of Florida
Childhood Obesity Prevention
Digitally Delivered Child Obesity Prevention for Parents in Home Visiting Programs
The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program.
- Trial name
- NCT07230808
- Testing
- digital intervention + home visiting curriculum, Home visiting curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Premature Loss of Primary Molars, Space Maintainer
Clinical Safety Guidelines for Managing Distal Shoe Complications
Distal shoe space maintainers are the standard of care for guiding the eruption of permanent first molars following the premature loss of the primary second molars.
- Conditions
- Premature Loss of Primary Molars, Space Maintainer, Soft Tissue Inflammation
- Trial name
- NCT07410442
- Testing
- Standard Clinical Practice Regimen
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Critical Illness, Pain
Pervasive Sensing and AI in Intelligent ICU
Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all.
- Conditions
- Critical Illness, Pain, Delirium, Confusion
- Trial name
- NCT05127265
- Testing
- Video Monitoring, Accelerometer Monitoring, Noise Level Monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Florida
Fibromyalgia
Effects of Breathing and Attention Training (BAT) on Pain Modulation
The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization.
- Trial name
- NCT05773482
- Testing
- Breathing and Attention Training (BAT), Breathing Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Subarachnoid Hemorrhage, Aneurysmal, Headache
BLOCK-SAH - PPF-Block for Post-SAH Headache
BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine +…
- Trial name
- BLOCK-SAH (NCT06008795)
- Testing
- Pterygopalatine Fossa Nerve Block with Ropivacaine and Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 195 people
- Sponsor
- University of Florida
Fibromyalgia, Physical Function
The Role of Resilience for Physical Functioning of Patients With Fibromyalgia Syndrome Using the 6-Min Walk Test
Fibromyalgia (FM) is a prevalent chronic pain disorder, characterized by widespread musculoskeletal pain and fatigue that is associated with significant functional limitations. Its mechanisms are only partially understood.
- Conditions
- Fibromyalgia, Physical Function, Six-minute Walk Test
- Trial name
- 6MWT (NCT07611539)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease, Deep Brain Stimulation
Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting
The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have…
- Trial name
- NCT07410598
- Testing
- Biphasic deep brain stimulation, Conventional deep brain stimulation, Theta burst deep brain stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Healthy
Adding Polyphenol-rich Pulses to Daily Diet Improves Skin Health by Reshaping the Skin Microbiome
Skin health is influenced by the microbiome, lipids, oxidative stress, inflammation, and UV exposure. A 12-week trial with 48 women aged 45-65 will test if polyphenol-rich pulses improve skin health by affecting these factors.
- Trial name
- NCT06538415
- Testing
- Pulse Diet, Control Rice Diet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Professional Caregivers Working With Infants Under Age 6 Months
Infant Diet and Caregiver Resistome
Antimicrobial resistance genes (ARGs) are the genes that allow bacteria to survive antibiotic treatments. These genes can be found in beneficial gut microbes, and occur more frequently in infants than adults.
- Trial name
- IDCR (NCT07680972)
- Testing
- None. Observational study
- Volunteers
- 40 people
- Sponsor
- University of Florida