Clinical trials: sponsored by University of Iowa
Diabetic Neuropathies
Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes, affecting about 50% of patients with diabetes and leading to severe morbidity, poor quality of life, high mortality, and high health care…
- Trial name
- NCT05169060
- Testing
- Fish Oil Concentrate, 1000 Mg Oral Capsule, Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Exudative Macular Degeneration, Wet Age-related Macular Degeneration
MMP-9 Inhibition for Recalcitrant Wet AMD
Wet (or neovascular) form of age-related macular degeneration (wAMD) is the most common cause of blindness in the Western world.
- Trial name
- NCT04504123
- Testing
- Doxycycline Hyclate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Arthritis Shoulder Glenohumoral Joint, Rotator Cuff Tear Arthropathy
Telerehabilitation After Shoulder Arthroplasty
The use of reverse total shoulder arthroplasty (RSA) has increased dramatically in the United States in recent years. The importance of postoperative physical therapy in the setting of anatomic total shoulder is well understood…
- Conditions
- Arthritis Shoulder Glenohumoral Joint, Rotator Cuff Tear Arthropathy, Arthropathy Shoulder
- Trial name
- NCT05499728
- Testing
- Telerehabilitation; physical therapy via telecommunication device (i.e. online video conferencing)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Delirium, Pain, Back
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
This initial study is a feasibility study for implementing thoracolumbar interfascial plane, or TLIP, blocks in older adults undergoing spinal fusion. TLIP blocks are done by using anesthesia.
- Conditions
- Delirium, Pain, Back, Spinal Fusion, Thoracolumbar Interfascial Plane Block
- Trial name
- NCT05461092
- Testing
- Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Blood Test, 3D CAM Delirium Severity Scoring
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Scoliosis Idiopathic, Early-Onset Scoliosis Deformity of Spine
Casting vs Bracing for Idiopathic Early-Onset Scoliosis
Comparison of casting and bracing for the treatment of idiopathic early onset scoliosis
- Trial name
- CVBT (NCT04500041)
- Testing
- Casting, Bracing
- Where
- 26 sites in United States, Italy and 1 more
- Volunteers
- 71 people
- Sponsor
- University of Iowa
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
NAFLD
Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity which can progress to deadly complications like end-stage liver disease and hepatocellular carcinoma.
- Trial name
- NCT04861571
- Testing
- Dietary intervention with very low calorie diet (VLCD), Control Arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Medication Adherence, Habits
Evaluation of a Habit-based Work-up to Support Medication Adherence
The goal of this clinical trial is to test the impact of a medication-taking habit worksheet and discussion with a pharmacist in patients who are prescribed a new chronic medication for cardiovascular disease or depression.
- Trial name
- NCT06230978
- Testing
- Habit workup, Standard Medication Counseling
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Adult ALL, Healthy
Iterative Design of Custom Dynamic Orthoses
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. It is expected that carbon fiber braces can be designed to reduce forces in the ankle.
- Trial name
- PRMRP-Norms (NCT04800510)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Iowa
Covid19
Symptom-Based Markers for COVID-19 Transmission
In this study, COVID-19 positive patients will be added to a bidirectional texting program to receive daily surveys about their symptoms with the infection.
- Trial name
- NCT04665245
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Iowa
Ankle Fractures, Post-traumatic Osteoarthritis
Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle. Research suggests that ankle arthritis develops following ankle fracture due, in part, to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP FPA CT (NCT05209347)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Sponsor
- University of Iowa
Healthy, Lower Limb Injury
Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics
Carbon fiber custom dynamic orthoses (CDOs) consist of a proximal cuff that wraps around the leg just below the knee, a posterior carbon fiber strut that stores and returns energy during gait, and a carbon fiber foot plate that…
- Conditions
- Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
- Trial name
- AFOCUFF (NCT05456295)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Endometrial Cancer
Activity and Cancer Survivorship Exercise Pilot
This early phase I clinical trial measures the changes in functional fitness following home-based comprehensive exercise program in patients who have endometrial cancer who have completed treatment.
- Trial name
- NCT07283029
- Testing
- Functional fitness following home-based comprehensive exercise program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Iowa
Physical Inactivity
Cognitive Control to Boost Physical Activity Adherence
This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle.
- Trial name
- BOOST (NCT06338774)
- Testing
- Cognitive training, Exercise
- Where
- 2 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Alcohol Use Disorder, Alcohol Dependence
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial
This study will collect data that measures the effects of a psychedelic intervention on patients struggling with alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Alcohol Abuse
- Trial name
- Psi or Ket (NCT06405607)
- Testing
- Psilocybin, Ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Iowa
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dental Prosthesis
Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers
The purpose of this study is to determine if MI Paste affects the bacteria and fungus present within the mouth, as well as to determine if MI Paste increases denture comfort and retention.
- Trial name
- NCT06406751
- Testing
- MI Paste
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Iowa
Tooth Extraction, Immediate Implant Placement
Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation
Mid-facial recession following immediate implant placement (IIP) in the place of a tooth poses a significant challenge for clinicians to treat.
- Trial name
- NCT05330702
- Testing
- Xenogeneic Volume-Stable Collagen Matrix (VCMX) graft No Intervention: No Soft Tissue Augmentation, Tuberosity Connective Tissue Graft (CTG)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa