Clinical trials: sponsored by University of Manchester
Stillbirth
The Tommy's National Rainbow Clinic Study
The death of a baby before or shortly after birth affects approximately 1 in every 250 pregnancies in the UK meaning that over 4,000 parents experience the death of a baby each year in the UK.
- Trial name
- NCT04393259
- Testing
- Rainbow Clinic Model of Antenatal Care
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Manchester
Acute Myeloid Leukemia, Stem Cell Transplantation
GRanulocyte Augmented Cord Blood Transplantation for Poor Risk leukaEmia
Allogeneic stem cell transplantation is the only potentially curative therapy for patients with high-risk Acute Myeloid Leukaemia, but relapse is common and remains the leading cause of death.
- Conditions
- Acute Myeloid Leukemia, Stem Cell Transplantation, Stem Cell Transplantation, Hematopoietic, Cord Blood Stem Cell Transplantation
- Trial name
- GRACE (NCT07372885)
- Testing
- Cord blood transplantation + conditioning + granulocytes of variable days according to study design
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Manchester
Stillbirth and Fetal Death, Perinatal Death
Mothers Working to Prevent Early Stillbirth Study 20-28
This project aims to identify factors linked to pregnancy losses occurring between 20 and 28 weeks of pregnancy that can be modified by changing mother's behaviour or healthcare provision.
- Trial name
- MiNESS20-28 (NCT06005272)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Quality of Life (QOL), Communication Barriers
The Mental Cost and Burden of Listening
This randomised controlled trial aims to test the effect of hearing adjustment using hearing aids, on the ease and effectiveness of communication such as listening effort, fatigue, and sentence recognition in noise, in addition…
- Conditions
- Quality of Life (QOL), Communication Barriers, Cognitive Performance, Fatigue, Mental
- Trial name
- NCT06951815
- Testing
- Hearing aids programmed to each participant's hearing loss.
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hypertrophic Cardiomyopathy (HCM)
Precision Pharmacogenetics and Genotype Class Based Prediction of Mavacamten Response in Obstructive Hypertrophic Cardiomyopathy
This research study, aims to understand why a specific heart medication called mavacamten works better for some people with hypertrophic cardiomyopathy (HCM) than for others. We believe the answer might be in our genes.
- Trial name
- PRO-Gene Mava (NCT07408427)
- Testing
- Observational study, no new intervention offered
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Manchester
Cardiovascular Diseases, Immune-Mediated Inflammatory Diseases
UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study
The goal of this observational study is to develop a large, deeply characterised cohort that will be a platform for collaborative clinical and translational research into cardiovascular (CV) disease (CVD) and…
- Trial name
- CARDIO-IMID (NCT06478277)
- Where
- 2 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Manchester
Physical Inactivity, Ethnic Minority Group
Feasibility RCT of Culturally Appropriate Physical Activity Strategies for Older Chinese Adults in the UK
The goal of this study was to explore the feasibility and acceptability of conducting a feasibility randomised controlled trial of culturally appropriate physical activity (PA) promotion strategies among older Chinese adults…
- Trial name
- NCT07365020
- Testing
- The culturally appropriate PA promotion strategies, WHO leaflet group (control)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hypertrophic Cardiomyopathy (HCM)
Myocardial Energetic Restoration in the Treatment of Obstructive Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy (HCM) is the most common inherited heart condition, where the heart muscles can thicken to the point of obstructing blood flow out of the heart.
- Trial name
- MERIT HCM (NCT07332767)
- Volunteers
- 20 people
- Sponsor
- University of Manchester
Individuals Presenting to Crisis Services
Method of Levels for People Using Community Crisis Services
A mental health crisis is when someone is so distressed they need urgent help from services; often because they behave in ways that poses risk to themselves or others.
- Trial name
- NCT05484518
- Testing
- Method of Levels Therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Manchester
Primary Care, Artificial Intelligence (AI)
Improving the Accuracy of Artificial Intelligence Triage in Primary Care
WHY ARE WE DOING THIS? When patients contact their GP practice, the first step is to work out what kind of help they need and how quickly it's needed. This is called 'triage' and is important for patient safety.
- Trial name
- NCT07237919
- Testing
- AI triage, No AI triage
- Where
- United Kingdom
- Volunteers
- 226,821 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cancer
APACE - Feasibility of Using Accelerometers to Measure Physical Activity in Cancer Patients on Early Phase Clinical Trials
Increased physical activity has been shown to improve outcomes for cancer patients, however the measure of activity is highly variable and understudied in cancer patients on early phase clinical trials where activity is used as a…
- Trial name
- APACE (NCT06868355)
- Testing
- No intervention (observational study)
- Where
- 8 sites in Italy, Spain and 1 more
- Volunteers
- 40 people
- Sponsor
- University of Manchester
Appetite
Low Calorie Sweeteners Effects on Appetite
The principal research question is whether the ingestion of stevia (rebaudioside A) in encapsulated format will have any effects on blood glucose, appetite and food intake in healthy human volunteers.
- Trial name
- NCT07018921
- Testing
- rebaudioside A
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cancer
Investigating the Tumour Immune Response of Radiotherapy
This study aims to investigate immune changes which occur before and following standard radiotherapy in a range of tumour types.
- Trial name
- TIMM-RAD (NCT05076500)
- Testing
- Biopsy and blood sample collection
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Manchester
Physical Activity, Aging
A Study of Physical Activity paTTerns and Major Health Events in Older People With Implantable Cardiac Devices
An observational study of physical activity patterns in 150 older adults with cardiac implantable electronic devices (CIED)
- Conditions
- Physical Activity, Aging, Cardiac Disease
- Trial name
- PATTErn (NCT03544424)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 183 people
- Sponsor
- University of Manchester
Respiration Disorders, Respiratory Failure
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
Aim of the research: To find out why antibiotics work differently in certain patients with severe pneumonia and sepsis. Background: Individuals can become very unwell from pneumonia, sometimes requiring admission to hospital or…
- Conditions
- Respiration Disorders, Respiratory Failure, Sepsis, Infection in ICU
- Trial name
- SIPRES (NCT06977165)
- Testing
- Antibiotic quantification
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- University of Manchester
Fetal Distress With Antenatal Problem, Fetal Growth Retardation
Validation of Sensors for Long-term Non-Invasive Fetal Monitoring
A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy.
- Trial name
- NCT06952777
- Testing
- Non-adhesive capacitively-coupled sensors
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Phantom Limb Syndrome With Pain
The Impact of a Virtual Reality Environment on Phantom Limb Pain
Phantom limb pain occurs in the majority of people who lose a limb. It significantly affects quality of life and is hard to manage.
- Trial name
- NCT03934528
- Testing
- Virtual environment activity
- Where
- United Kingdom
- Sponsor
- University of Manchester
Hypertension, Pregnancy
Effects of Dietary Nitrate in Hypertensive Pregnant Women
High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby.
- Trial name
- NCT02520687
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Manchester
Systemic Sclerosis, Raynaud Phenomenon
Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot
The goal of this observational pilot data acquisition study is to establish if target users can obtain diagnostic quality images in the clinic, from participants with Systemic Sclerosis (SSc), and SSc spectrum conditions.
- Trial name
- NCT06291142
- Testing
- Observation - Nailfold capillaroscopy
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Myositis, Idiopathic Inflammatory Myopathy
MYOPROSP - a Prospective Cohort Study in Myositis
Adult patients with suspected or confirmed idiopathic inflammatory myopathy (IIM) will be recruited. Patients will be approached, consented, have baseline demographics, diagnostics and disease activity measures recorded, and…
- Trial name
- MYOPROSP (NCT02468895)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester