Clinical trials: sponsored by University of Manchester
Haematopoietic Stem Cell Transplantation
Precision Medicine for Stem Cell Transplantation
A study of patients undergoing haematopoietic stem cell transplantation, a procedure in which patients are infused with stem cells from a donor, resulting in a new immune system that eliminates cancer or replaces diseased bone…
- Trial name
- PM-SCT (NCT05567289)
- Testing
- Blood sample collection, Bone marrow aspirate
- Where
- 3 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
The Effects of Cerebellar rTMS on the Brain
The Effects of Cerebellar rTMS on Brain Activity
Swallowing function is controlled by two swallowing centres (one on each half of the brain). There is a dominant and non-dominant swallowing centre.
- Trial name
- NCT05736380
- Testing
- Cerebellar rTMS
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Mucopolysaccharidosis Type IIIA
Gene Therapy with Modified Autologous Hematopoietic Stem Cells for Patients with Mucopolysaccharidosis Type IIIA
Patients with MPS IIIA have a clinical disorder marked by severe and progressive brain disease and neurological symptoms due to the accumulation of undigested glycosaminoglycans in all cells of the body.
- Trial name
- NCT04201405
- Testing
- Autologous CD34+ cells transduced with a lentiviral vector containing the human SGSH gene
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Manchester
Kidney Transplant, Kidney Transplant Donor
Outcomes of a Pre-operative Exercise Programme for Live Donor and Recipient Kidney Transplant Patients
The goal of this clinical trial is to learn if a pre-operative outpatient exercise programme, monitored by a smart wearable device is acceptable to live kidney donor and recipient transplant patients.
- Conditions
- Kidney Transplant, Kidney Transplant Donor, Kidney Transplant Recipient
- Trial name
- OPERATe (NCT06858098)
- Testing
- Exercise programme, Wearable smart device
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Manchester
Healthy Subjects (HS)
Aftereffects of PES Preconditioned with RTMS on the Human Pharyngeal Motor Cortex
The goal of this interventional study is to optimize the excitatory brain effects of combined neuromodulatory therapies on swallowing areas of the brain.
- Trial name
- NCT06884488
- Testing
- repetitive transcranial magnetic stimulation (Magstim Super Rapid stimulator, The Magstim Company Ltd, Whitland, UK), pharyngeal electrical stimulation (Digitimer model DS7; Welwyn-Garden City, Herts, UK)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Bipolar Disorder I or II
A Compassionate-focused Intervention for Older People with Bipolar Disorder
The aim of this study is to determine whether it is feasible to deliver a 9-session compassionate-focused therapy for older people with bipolar disorder.
- Trial name
- NCT06882590
- Testing
- Compassionate-focused therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Manchester
Willingness to Participate
Willingness to Participate in a Daily Smartphone Well-being Study
This clinical trial aims to compare the effectiveness of financial and social incentives in motivating urban populations to participate in Experience Sampling Method (ESM) wellbeing studies and explore alternative incentive…
- Trial name
- NCT06862999
- Testing
- No Incentive Email, Financial Incentive Email, Social Incentive Email
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- University of Manchester
Mental Health, Neurodevelopment
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life.
- Conditions
- Mental Health, Neurodevelopment, ADHD, Autism
- Trial name
- NCT06823492
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Endometrial Cancer
Methylated Biomarkers Predictive of Endometrial Cancer Risk
The goal of this observational study is to identify endometrial cancer risk predictive biomarkers and to optimise the methodology for their detection and quantification in non-invasive samples.
- Trial name
- BioMEC (NCT06800677)
- Testing
- Hysterectomy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Manchester
HIV Infections
HIV and Changes in the Gut Microbiome After Changes in Antiretroviral Therapy (ART)
This is a study that aims to contribute to the understanding of how antiretroviral therapy effects the gut microbiome which, if known, could inform decisions about drug choices at an individual level.
- Trial name
- NCT06100211
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Manchester
Type 2 Diabetes
Evidence-based Text Messages to Target Diet and Physical Activity
This research aims to develop a bank of text messages based on behaviour change techniques targeting specific diet and physical activity behaviours in people with type 2 diabetes
- Trial name
- NCT05641402
- Testing
- Text messages
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- University of Manchester
Critical Illness
Intensive Care Decision-making, Survival and Dying Well
The goal of this study is to investigate how the experiences of intensive care patients and their end-of-life wishes affect their willingness to accept intensive care treatment at different chances of survival.
- Trial name
- NCT06027684
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Manchester
Pain, Chronic, Sleep Disturbance
Alpha Entrainment for Pain and Sleep (Extension)
Long-term pain affects one-third of the United Kingdom population and can be very disabling. People experiencing long-term pain often suffer from disturbed sleep because of their pain symptoms, and disturbed sleep can then make…
- Trial name
- NCT05699837
- Testing
- Audio or visual alpha (10Hz) stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Manchester
Total Elbow Replacement
Prognostic Factors Associated With Failure of Total Elbow Replacement
This observational study aims to evaluate potential prognostic factors for TER failure . The National Joint Registry (NJR) currently contains the largest elbow registry dataset in the world, which has been shown to have high…
- Trial name
- NCT06760585
- Where
- United Kingdom
- Volunteers
- 4,073 people
- Sponsor
- University of Manchester
Bile Acid Diarrhea
The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial
Bile acid diarrhoea is a common cause of chronic watery diarrhoea. Treatment is life-long medication. However, about 50% of people have ongoing, bothersome diarrhoea.
- Trial name
- NCT06259396
- Testing
- The 8x5 Diet
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Manchester
Swallowing, Dysphagia
Cerebellar Metaplasticity in the Swallowing Motor System
Dysphagia is common and leads to significant morbidity and mortality within healthcare settings. Current approaches to dysphagia management involve altering the consistency of food and fluids.
- Trial name
- NCT06721533
- Testing
- Cerebellar rTMS
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cardiovascular Diseases, Rheumatologic Disease
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
The researchers would like to know more about cardiovascular abnormalities in patients with immune-mediated inflammatory diseases (IMID) and with the aim to provide new biomarkers (clinical, blood, imaging) for early diagnosis…
- Trial name
- GM CARDIO-IMID (NCT06600737)
- Where
- United Kingdom
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Functional Neurological Disorder
Body Signal Integration Training: A Case Series
The goal of this clinical trial is to learn about an intervention package in individuals with Functional Neurological Disorder (FND).
- Trial name
- NCT05941702
- Testing
- Body Signal Integration Training
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Manchester
Eating Disorders
Case-Series Examination of a Brief CAT-Informed Intervention for Young People Experiencing Difficulties With Eating (RIDE)
Eating Disorders (ED) are mental health conditions where people alter food intake in some way to help with weight gain, managing emotions or other situations. EDs are increasingly common in young people.
- Trial name
- RIDE (NCT05746364)
- Testing
- Brief CAT-Informed Intervention for Young People experiencing Difficulties with Eating
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Manchester
Stroke, Emotionality
Piloting the Attention Training Technique for Post-Stroke Emotionalism
The aim of this mutli-phasic systematic case series is to explore if the Attention Training Technique (ATT) can improve symptoms of Post Stroke Emotionalism.
- Conditions
- Stroke, Emotionality, Pseudobulbar Affect, Lability Emotional
- Trial name
- NCT06457126
- Testing
- Attention Training Technique
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Manchester