Clinical trials: sponsored by University of Manchester
Pregnancy Related, Delivery of Health Care
Evaluating the Saving Babies Lives Care Bundle Version 2
The purpose of this study is to learn about the implementation of NHS England's Saving Babies Lives Care Bundle Version 2 to reduce perinatal mortality.
- Trial name
- eVOLVE (NCT06453954)
- Where
- United Kingdom
- Volunteers
- 1,773 people
- Sponsor
- University of Manchester
Child Mental Disorder, Anxiety Disorders
Youth Metacognitive Therapy Feasibility Trial
One in eight children and young people (CYP) suffer mental health problems needing support or treatment and 5% have more than one such problem.
- Conditions
- Child Mental Disorder, Anxiety Disorders, Depression
- Trial name
- YoMETA (NCT05260060)
- Testing
- Treatment as usual: Control, Group Metacognitive Therapy (Group-MCT): Experimental
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Manchester
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Stroke, Psychological Distress
Wellbeing After Stroke (WAterS): Supporting Adjustment and Wellbeing After Stroke
Stroke survivors face a range of mental health challenges adjusting post-stroke. There is a lack of treatment options and clinical psychologist workforce to deliver support.
- Conditions
- Stroke, Psychological Distress, Cognitive Dysfunction, Communication Disorders
- Trial name
- WAterS (NCT04655937)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Manchester
Rheumatoid Arthritis, Psoriatic Arthritis
Tapering of Biologics in Inflammatory Arthritis Patients in Remission
Rheumatoid arthritis (RA) and Psoriatic Arthritis (PsA) are types of inflammatory arthritis. They are disabling conditions caused by inflammation in joints that can lead to pain, stiffness, fatigue and joint damage.
- Trial name
- TAPER (NCT04429776)
- Testing
- Drug level testing with feedback provided, Drug level testing with no feedback provided
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- University of Manchester
SARS Virus
Immune Cells in Inflammatory Arthritis With Coronaviruses, Including COVID-19
A team at the University of Manchester are developing a test that tcould be helpful in detecting immunity to the Coronavirus (which causes the COVID-19 disease) in participants with inflammatory arthritis.
- Trial name
- NCT04363047
- Testing
- 40ml blood sample
- Where
- United Kingdom
- Volunteers
- 125 people
- Sponsor
- University of Manchester
Head and Neck Neoplasms, Hearing Loss
The Effects on Auditory Function of RADiotherapy and Chemotherapy Treatments for Head and Neck Tumours (EARAD)
Radiotherapy and combined radiotherapy and chemotherapy are used to treat most tumours in the head and neck region. Unfortunately, these treatments often result in hearing loss and tinnitus that has a negative impact on quality…
- Trial name
- EARAD (NCT03914378)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Chronic Limb-Threatening Ischemia, Surgery-Complications
Use of CPETarm for Risk Stratification of Patients With CLTI
This is a prospective cohort study of patients undergoing surgery for chronic limb threatening ischaemia. Prior to surgery, patients will undergo CardioPulmonary Exercise testing (CPET) using an arm ergometer.
- Trial name
- NCT06404229
- Testing
- CardioPulmonary Exercise Testing
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Manchester
Total Elbow Replacement
Total Elbow Replacement in England: Analysis of National Joint Registry and Hospital Episode Statistics Data
The goal of this observational registry study is to provide detailed descriptions of the patients who are receiving primary total elbow replacement surgery in England.
- Trial name
- NCT06355011
- Testing
- Total Elbow Replacement
- Where
- United Kingdom
- Volunteers
- 3,891 people
- Sponsor
- University of Manchester
Educational Study
Virtual Reality (VR) Paediatric Tracheostomy Training
This study aims to evaluate the use of an unsupervised virtual reality training tool. This tool is used to teach nurses, doctors and other healthcare workers and their students how to manage tracheostomy emergencies in children.
- Trial name
- NCT06350708
- Testing
- Virtual reality (VR) tracheostomy educational tool
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Anxiety, Depression
Metacognitive Therapy for Common Mental Health Problems in Autistic CYP: A Case Series
Anxiety and Depression are common in young people (CYP) and especially in CYP with a diagnosis of Autism. Autistic people often say therapy has not been adapted to meet their needs.
- Trial name
- NCT05980143
- Testing
- Metacognitive Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Manchester
Breast Cancer Risk
FH-Risk 2.0: Updating Breast Cancer Risk Estimates
In the UK women with a strong family history of breast cancer are eligible for breast cancer risk estimation via Family History Risk and Prevention Clinics (FHRPCs).
- Trial name
- NCT05082740
- Testing
- Notification of a revised breast cancer risk estimate
- Where
- United Kingdom
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hypertension, Adherence, Medication
OUTREACH: Urine Analysis and Antihypertensive Treatment
Non-adherence to antihypertensive treatment is one of the leading causes of suboptimal blood pressure control and translates into increased risk of cardiovascular morbidity and mortality.
- Trial name
- OUTREACH (NCT03293147)
- Testing
- HPLC-MS/MS-guided intervention, Standard care
- Where
- 12 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Manchester
Colorectal Cancer Metastatic, Peritoneal Metastases
Development of an IDEAL Framework to Standardise Cytoreductive Surgery for Colorectal Peritoneal Metastases
Cytoreduction surgery (CRS) followed by hyperthermic intra-operative peritoneal chemotherapy (HIPEC) is a relatively new treatment for selected patients with peritoneal metastases of colorectal origin (PMCR).
- Trial name
- IDEAL-PM (NCT03733184)
- Testing
- Cytoreduction and Heated Intraperitoneal Surgery
- Volunteers
- 200 people
- Sponsor
- University of Manchester
Subarachnoid Hemorrhage
SC IL-1Ra in SAH - Phase III Trial (SCIL)
This phase III trial will establish whether IL-1Ra, with sub-cutaneous (SC) administration twice daily for up to 21 days post aneurysmal subarachnoid haemorrhage (aSAH), improves clinical outcome as measured by ordinal shift in…
- Trial name
- SCIL (NCT03249207)
- Testing
- IL-1Ra
- Where
- 17 sites in United Kingdom
- Volunteers
- 612 people
- Sponsor
- University of Manchester
Typical Atrial Flutter
Fluoroscopic, Contact Force and Local Impedance With Ultra-high Density Mapping Guided Radiofrequency Ablation Comparison for cavoTricuspid Isthmus dependenT Atrial fluttER: the FLUTTER Study
Catheter ablation is a first-line treatment for patients with cavotricuspid isthmus (CTI) dependent atrial flutter (AFL; also known as typical AFL), a common arrhythmia.
- Trial name
- FLUTTER (NCT04434599)
- Testing
- Fluoroscopically guided ablation, Contact force guided ablation, Local impedance guide ablation
- Sponsor
- University of Manchester
Rheumatoid Arthritis
Methotrexate Use Improvement in Rheumatoid Arthritis Using Biomarker Feedback
The study is a prospective single-centre randomised controlled trial to examine the feasibility of a fully powered randomised controlled trial to examine if HPLC-SRM-MS guided intervention is superior to standard clinical care in…
- Trial name
- MIRA (NCT03913728)
- Testing
- Drug level blood tests, Telephone Interview
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Manchester
Idiopathic Inflammatory Myopathies
JAK 1/2 Inhibitor, Baricitinib, in the Treatment of Adult IIM
This study aims to investigate the clinical efficacy of baricitinib in patients with adult idiopathic inflammatory myositis (IIM).
- Trial name
- MYOJAK (NCT04208464)
- Testing
- Baricitinib
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Manchester
Lung Cancer Stage III
Developing Circulating and Imaging Biomarkers Towards Personalised Radiotherapy in Lung Cancer
In stage 3 NSCLC, treatment and follow-up are generally performed in a 'one-size-fits-all' manner. In the setting of metastatic lung cancer there has been considerable success identifying biomarkers, which allow treatments to be…
- Trial name
- VIGILANCE (NCT06086574)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Manchester
Mental Health
Feasibility & Acceptability of One-Session MOL Therapy in Primary Care
People sometimes wait a long time for psychological therapy and could have this sooner if they had only one session. This is because they may only require one session to meet their needs if this is provided quickly (Cannistrà et…
- Trial name
- FAOMTPC (NCT06063824)
- Testing
- Single-Session Method of Levels Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Manchester