Clinical trials: sponsored by University of Manchester
Dermatologic Disease
Addressing Inequity in Dermatology
The objectives of this study are to understand the variation in dermatoses presenting in individuals from different ancestry backgrounds. This will be conducted at multiple NHS hospitals in England.
- Trial name
- NCT06056648
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Manchester
Anxiety, Depression
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
Background: Cardiac rehabilitation (CR) services aim to improve heart disease patients' health and quality of life and reduce the risk of further cardiac events.
- Conditions
- Anxiety, Depression, Cardiac Rehabilitation
- Trial name
- NCT05956912
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Self-Examination, Vulvar Cancer
Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study
Vulval cancer, while rare, has increased in incidence by 17% since the 1990s. It is strongly associated with age, thus this increasing trend is likely to continue with extended life expectancy.
- Conditions
- Self-Examination, Vulvar Cancer, Vulvar Lichen Sclerosus, Vulval Intraepithelial Neoplasia
- Trial name
- NCT04952961
- Testing
- Training in Vulval Self-Examination
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Manchester
Hearing Loss
INSPIRES Hearing Health Trial - INnovative Psychological Intervention to REduce Stigma in Hearing Health Trial
Background: Reminding people they are moral adaptable human beings ("self-affirming") reduces the perceived stigma associated with wearing hearing aids and increases actual hearing aid use.
- Trial name
- INSPIRES (NCT04680845)
- Testing
- Self-affirmation
- Where
- United Kingdom
- Volunteers
- 3,012 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Pain, Chronic, Sleep Disturbance
hBET for Pain and Sleep Feasibility
Long-term pain affects one-third of the United Kingdom population and can be very disabling. People experiencing long-term pain often suffer from disturbed sleep because of their pain symptoms, and disturbed sleep can then make…
- Trial name
- NCT04176861
- Testing
- home-based Brainwave Entrainment Technology
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Manchester
Endometrial Cancer, Cardiovascular Diseases
Optimising Cardiovascular Health in Endometrial Cancer Survivors
Women successfully treated for endometrial cancer remain at higher risk of dying than women without a history of the disease, predominately due to an excess risk of cardiovascular disease.
- Trial name
- OPTIMUS (NCT05216913)
- Testing
- Lifestyle modification, Cardiovascular Agents, Other, QRISK 3 Score
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Manchester
Class II Division 1 Malocclusion
A Prospective Randomized Controlled Trial to Evaluate the Effectiveness of the Two Different Appliances in the Treatment of Class II Division 1 Malocclusion
Twin-Block treatment and Dynamax treatment for Class II division 1 malocclusion do not have different effects with regards to treatment duration, the quality of dento-occlusal outcome, skeletal and soft tissue profile, patient…
- Trial name
- NCT00957489
- Testing
- Dynamax appliance, Twin-block appliance
- Where
- 2 sites in United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Psychosis, Suicidal
Acceptability and Feasibility of MOL in Acute Inpatient Units
The current study aims to test the acceptability and feasibility of a psychological therapy called Method of Levels (MOL) as an intervention for people in acute psychiatric inpatient units who are experiencing psychosis and/or…
- Trial name
- NCT05377294
- Testing
- Method of Levels therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Manchester
Psychosis, Suicide Prevention
Cognitive AppRoaches to coMbatting Suicidality
This is a randomised controlled trial which investigates the effectiveness of CARMS (Cognitive AppRoaches to coMbatting Suicidality) therapy in reducing suicidal thoughts and how well CARMS works in practice within the NHS.
- Conditions
- Psychosis, Suicide Prevention, Suicidality
- Trial name
- CARMS (NCT03114917)
- Testing
- Cognitive AppRoaches to coMbatting Suicidality (CARMS)
- Where
- 4 sites in United Kingdom
- Volunteers
- 329 people
- Sponsor
- University of Manchester
Breast Cancer, Overweight and Obesity
Acceptance and Usability of an App Promoting Healthy Behaviours Amongst Young Women at Increased Risk of Breast Cancer
It is estimated that around 20% of breast cancers (BC) in the UK are preventable through adherence to appropriate health behaviours, i.e., healthy diet, physical activity, limited alcohol, not smoking, and that women at increased…
- Conditions
- Breast Cancer, Overweight and Obesity, Diet, Healthy, Weight Gain
- Trial name
- NCT05460650
- Testing
- App Promoting Healthy Behaviours
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Depression, Anxiety
Treating Depression and Anxiety in the Cardiac Rehabilitation Pathway
Cardiac rehabilitation (CR) services aim to improve heart disease patients' health and quality of life, and reduce the risk of further cardiac events.
- Conditions
- Depression, Anxiety, Cardiac Rehabilitation
- Trial name
- PATHWAY (NCT02420431)
- Testing
- Metacognitive Therapy, Cardiac Rehabilitation (treatment as usual)
- Where
- 5 sites in United Kingdom
- Volunteers
- 332 people
- Sponsor
- University of Manchester
Depression, Anxiety
A Self-Help Metacognitive Therapy for Cardiac Rehabilitation Patients (PATHWAY WS3)
Depression and anxiety are highly prevalent in people with heart disease, causing immense human and economic burden. Available pharmacological and psychological interventions have limited efficacy and the needs of these patients…
- Conditions
- Depression, Anxiety, Cardiac Rehabilitation, Psychological Distress
- Trial name
- NCT03999359
- Testing
- Home-based Metacognitive Therapy
- Where
- 5 sites in United Kingdom
- Volunteers
- 242 people
- Sponsor
- University of Manchester
Depression, Anxiety
Pathway Study WS3 - Home Based Metacognitive Therapy for Cardiac Rehabilitation Patients
Depression and anxiety are highly prevalent in people with heart disease, causing immense human and economic burden. Available pharmacological and psychological interventions have limited efficacy and the needs of these patients…
- Conditions
- Depression, Anxiety, Cardiac Rehabilitation, Psychological Distress
- Trial name
- NCT03129282
- Testing
- Home-based Metacognitive Therapy (Home-MCT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- University of Manchester
Breast Cancer
What Are the Benefits and Harms of Risk Stratified Screening in the NHS Breast Screening Programme: Study Protocol
This study aims to identify key benefits and harms of integrating risk stratification (the BC-Predict intervention) into the NHS Breast Screening Programme.
- Trial name
- NCT04359420
- Testing
- BC-Predict, NHS Breast Screening Programme
- Where
- United Kingdom
- Volunteers
- 32,298 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Oropharyngeal Dysphagia, Stroke
The Utility of Cerebellar Transcranial Magnetic Stimulation in the Neurorehabilitation of Dysphagia After Stroke
The study is designed to explore the effectiveness of non-invasive cerebellar stimulation to enhance motor plasticity in the cortex after stroke.
- Trial name
- NCT03274947
- Testing
- Cerebellar TMS
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Psychosis, Psychosis-Related PTSD
Attachment-focused iMAgery Therapy for PSychosis (A-iMAPS)
The relationships we have in childhood affect how we relate to others across our life, including how safe or secure we feel. If our caregivers do not meet our needs well enough in childhood, this can lead to an 'insecure…
- Trial name
- NCT05042050
- Testing
- A-iMAPS
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Total Hip Replacement
Unrestricted Rehabilitation Pathway Following Total Hip Replacement
The purpose of ReHip2 is to explore the impact on function and quality of life in patients following Total Hip Replacement (THR).
- Trial name
- ReHip2 (NCT03833258)
- Testing
- Rehabilitation with no precautions
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Manchester
All Comers
A-EYE: A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.
This is a data collection study involving the gathering of clinical data and OCT (optical coherence tomography) scans from 350 patients.
- Trial name
- A-EYE (NCT04901468)
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Manchester
Injury of Nerves at Wrist and Hand Level
A Phase I Trial of a Novel Synthetic Polymer Nerve Conduit 'Polynerve' in Participants With Sensory Digital Nerve Injury
Participants with a traumatic sensory nerve injury in the hand will be recruited to the study. Participants found to have a nerve gap of at least 5 mm and no greater than 20mm will undergo repair with the Polynerve.
- Trial name
- UMANC (NCT02970864)
- Testing
- Polynerve
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Manchester
Colorectal Cancer, Survivorship
Healthy Eating and Active Lifestyle After Bowel Cancer: HEAL ABC
Trial Design: This is a feasibility randomised controlled trial. Aim: The study aims to test the Healthy Eating and Active Lifestyle After Bowel Cancer - HEAL ABC intervention and HEAL ABC resources for feasibility and will…
- Conditions
- Colorectal Cancer, Survivorship, Behavior, Health
- Trial name
- HEALABC (NCT04227353)
- Testing
- HEAL ABC
- Where
- 3 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Manchester